List of works by Juan Manuel Castellano

A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates

scientific article published on July 2013

Activation of Microglia in Specific Hypothalamic Nuclei and the Cerebellum of Adult Rats Exposed to Neonatal Overnutrition

scientific article published on 01 April 2011

Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects.

scientific article published on 20 April 2010

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.

scientific article published on 14 October 2004

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

scientific article published on 9 October 2008

An alternative transcription start site yields estrogen-unresponsive Kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats

scientific article

Animal Modeling of Early Programming and Disruption of Pubertal Maturation.

scientific article published on 17 December 2015

Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis

scientific journal article

Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition

scientific article published on 2 June 2005

Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54

scientific article published on 16 September 2004

Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.

scientific article published on 19 February 2009

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

scientific article published on 15 April 2008

Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score).

scientific article

Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.

scientific article published on 8 July 2004

Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission

scientific article

Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen

scientific article

Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus after sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats

scientific article published on 22 July 2014

Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system

scientific article published on 28 June 2011

Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat.

scientific article published on 6 January 2005

Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty

scientific article published on 18 July 2006

Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats

scientific article published on 2 March 2006

Epigenetic control of female puberty

scientific journal article

Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression

scientific article

Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?

scientific article published on 6 July 2006

Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation?

scientific journal article

Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats

scientific article published in September 2006

Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis.

scientific article

Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat.

scientific article

Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3

scientific article published on 07 November 2019

Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.

scientific article

Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways

scientific article published on 22 December 2017

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.

scientific article published on 13 January 2009

Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion

scientific article

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

scientific article published on 22 August 2008

Kisspeptins: bridging energy homeostasis and reproduction

scientific article published on 25 August 2010

Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure

scientific article

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome

scientific article

Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion.

scientific article published on 18 May 2015

Metabolic control of female puberty: potential therapeutic targets.

scientific article

Metabolic control of puberty onset: new players, new mechanisms

scientific article published on 21 December 2009

Metabolic programming of puberty: sexually dimorphic responses to early nutritional challenges

scientific article published on 10 June 2013

Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

article published in the Proceedings of the National Academy of Sciences of the United States of America

Metabolic regulation of kisspeptin.

scientific article published on January 2013

Neuromedin s as novel putative regulator of luteinizing hormone secretion.

scientific article

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

scientific article (publication date: November 2007)

Obesity-induced hypogonadism in the male: premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms

scientific article published on January 2014

Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.

scientific article published on 22 August 2006

Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.

scientific article

Pattern of orexin expression and direct biological actions of orexin-a in rat testis

scientific journal article

Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.

scientific article published on 23 December 2008

Role of neurokinin B in the control of female puberty and its modulation by metabolic status

scientific article published on February 2012

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

scientific article published in Nature Communications

Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat.

scientific article

Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats

scientific article published on 3 January 2006

The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat.

scientific article published on June 2010

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

scientific article published on 4 September 2009

Transcription of the human EAP1 gene is regulated by upstream components of a puberty-controlling Tumor Suppressor Gene network

scientific article published on 19 December 2011

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