List of works - Anton Wellstein

A distinct role for secreted fibroblast growth factor-binding proteins in development

scientific article

A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells.

scientific article

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

scientific article

AF-DX 116 discriminates heart from gland M2-cholinoceptors in man

scientific article published on 01 January 1989

Agonist binding at alpha 2-adrenoceptors of human platelets using 3H-UK-14,304: regulation by Gpp(NH)p and cations

scientific article published on 01 July 1987

Altered Rho GTPase signaling pathways in breast cancer cells.

scientific article published on March 2004

An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release

scientific article published on 01 May 2001

An additional 5'-upstream exon exists in the human pleiotrophin-encoding gene.

scientific article published on February 1995

An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer.

scientific article

Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.

scientific article published on 9 July 2002

Beta-adrenoceptor sites in maturing red blood cells of the rat: differing development of agonist and antagonist binding

scientific article published on 01 January 1982

Chlorpheniramine plasma concentration and histamine H1-receptor occupancy.

scientific article published in August 1995

Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons.

scientific article published on 18 July 2008

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.

scientific article published on 4 October 2017

Comparison of biological phenotypes according to midkine expression in gastric cancer cells and their autocrine activities could be modulated by pentosan polysulfate

scientific article published on 01 September 1997

Comparison of chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter by the androgen and glucocorticoid receptor.

scientific article published on August 1999

Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype

scientific article

Desensitization of the beta-adrenoceptor-adenylate cyclase system of immature erythrocytes by in-vivo treatment of rats with isoprenaline

scientific article published on 01 January 1981

Detectable Inhibition of Heparin-Binding Growth Factor Activity in Sera From Patients Treated With Pentosan Polysulfate

scientific article published on 01 July 1993

Differential regulation of a fibroblast growth factor-binding protein by receptor-selective analogs of retinoic acid

scientific article published on 01 December 2000

Differential regulation of a fibroblast growth factor-binding protein during skin carcinogenesis and wound healing.

scientific article

Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of HL-60 cells

scientific article published on 01 August 1997

Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma

scientific article

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

scientific article

E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells.

scientific article published on September 2006

Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.

scientific article published on September 2003

Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor.

scientific article published on 27 July 2009

Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass

scientific article

Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury

scientific article published on 6 June 2007

Energy-dependent extrusion of cyclic 3',5'-adenosine-monophosphate. A drug-sensitive regulatory mechanism for the intracellular nucleotide concentration in rat erythrocytes

scientific article published on 01 December 1982

Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.

scientific article published on August 2007

Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

scientific article published on 23 January 2003

Ethnic differences in response to beta-blockade: fact or artefact? A study with bisoprolol and propranolol.

scientific article published in January 1988

Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma.

scientific article

Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon

scientific article

Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue.

scientific article

Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism

scientific article published in Scientific Reports

HER-2/neu is rate-limiting for ovarian cancer growth. Conditional depletion of HER-2/neu by ribozyme targeting

scientific article

Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway

scientific article published on 01 March 2005

Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.

scientific article published in April 2003

Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus

scientific article published on December 1996

Hunting ALK to feed targeted cancer therapy.

scientific article published in March 2011

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display

scientific article

Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development

scientific article published on 20 December 2001

Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity.

scientific article published on January 2004

Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways.

scientific article

Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion

scientific article published on 4 July 2016

Late failure of a split-thickness skin graft in the setting of homozygous factor V Leiden mutation: a case report and correlative animal model from the Wound Etiology and Healing (WE-HEAL) study

scientific article published on 13 September 2013

Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression

scientific article published on 02 December 2019

Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

scientific article (publication date: 27 September 2002)

Omics-based molecular target and biomarker identification.

scientific article published on January 2011

Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma.

scientific article published on September 2004

Penbutolol: beta-adrenoceptor interaction and the time course of plasma concentrations explain its prolonged duration of action in man

scientific article published on 01 January 1985

Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements.

scientific article published on July 1998

Pleiotrophin (PTN) Expression and Function and in the Mouse Mammary Gland and Mammary Epithelial Cells ⬇️

scientific article published on October 15, 2012

Pleiotrophin drives a prometastatic immune niche in breast cancer

scientific article published in 2023

Properties of agonist binding at the beta-adrenoceptor of the rat reticulocyte

scientific article published on 01 October 1982

Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells.

scientific article

RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response

scientific journal article

Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man

scientific article published on 01 January 1985

Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs

scientific article published on 06 January 2014

Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex

scientific article

Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells.

scientific article published on 27 April 2001

Ribozyme targeting of the growth factor pleiotrophin in established tumors: a gene therapy approach.

scientific article published in February 2005

Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome

scientific article

Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription

scientific article published on 01 March 2001

Serum levels of the angiogenic factor pleiotrophin in relation to disease stage in lung cancer patients.

scientific article published on March 2002

Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer

scientific article published on 26 August 2019

Signal transduction pathways involved in the mitogenic activity of pleiotrophin. Implication of mitogen-activated protein kinase and phosphoinositide 3-kinase pathways

scientific article published on 01 August 1997

Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma

scientific article published on 01 January 1984

Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing Reveals Novel and Distinct mRNA Isoforms in Human Bone Marrow Cell Subpopulations.

scientific article published on 27 March 2019

Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells

scientific article published in 2023

Structure of the human heparin-binding growth factor gene pleiotrophin.

scientific article published on September 1992

Superoxide modulates myogenic contractions of mouse afferent arterioles

scientific article published on 22 August 2011

Systemic morphine administration suppresses genes involved in antigen presentation

scientific journal article

The efficacy of 9-cis retinoic acid in experimental models of cancer.

scientific article published on January 1996

The nuclear coactivator amplified in breast cancer 1 maintains tumor-initiating cells during development of ductal carcinoma in situ

scientific article published on 15 July 2013

The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.

scientific article published on May 2008

The potential role of the heparin-binding growth factor pleiotrophin in breast cancer.

scientific article published on January 1994

The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.

scientific article

Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer

scientific article

Transcriptional Repression of AIB1 by FoxG1 Leads to Apoptosis in Breast Cancer Cells ⬇️

scientific article published on 09 May 2013

Up-regulation of a fibroblast growth factor binding protein in children with renal diseases.

scientific article

Utility of a human-mouse xenograft model and in vivo near-infrared fluorescent imaging for studying wound healing

scientific article

Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors

scientific article published in June 2005

Why monitor angiogenic factors in patients' urine?

scientific article published on 01 March 1994

p47 phox Is Required for Afferent Arteriolar Contractile Responses to Angiotensin II and Perfusion Pressure in Mice ⬇️

scientific article published on December 19, 2011

List of works by Anton Wellstein

A distinct role for secreted fibroblast growth factor-binding proteins in development

A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells.

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

AF-DX 116 discriminates heart from gland M2-cholinoceptors in man

Agonist binding at alpha 2-adrenoceptors of human platelets using 3H-UK-14,304: regulation by Gpp(NH)p and cations

Altered Rho GTPase signaling pathways in breast cancer cells.

An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release

An additional 5'-upstream exon exists in the human pleiotrophin-encoding gene.

An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer.

Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.

Beta-adrenoceptor sites in maturing red blood cells of the rat: differing development of agonist and antagonist binding

Chlorpheniramine plasma concentration and histamine H1-receptor occupancy.

Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons.

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib.

Comparison of biological phenotypes according to midkine expression in gastric cancer cells and their autocrine activities could be modulated by pentosan polysulfate

Comparison of chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter by the androgen and glucocorticoid receptor.

Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype

Desensitization of the beta-adrenoceptor-adenylate cyclase system of immature erythrocytes by in-vivo treatment of rats with isoprenaline

Detectable Inhibition of Heparin-Binding Growth Factor Activity in Sera From Patients Treated With Pentosan Polysulfate

Differential regulation of a fibroblast growth factor-binding protein by receptor-selective analogs of retinoic acid

Differential regulation of a fibroblast growth factor-binding protein during skin carcinogenesis and wound healing.

Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of HL-60 cells

Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells.

Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.

Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor.

Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass

Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury

Energy-dependent extrusion of cyclic 3',5'-adenosine-monophosphate. A drug-sensitive regulatory mechanism for the intracellular nucleotide concentration in rat erythrocytes

Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.

Estradiol rapidly activates Akt via the ErbB2 signaling pathway.

Ethnic differences in response to beta-blockade: fact or artefact? A study with bisoprolol and propranolol.

Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma.

Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon

Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue.

Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism

HER-2/neu is rate-limiting for ovarian cancer growth. Conditional depletion of HER-2/neu by ribozyme targeting

Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway

Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.

Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus

Hunting ALK to feed targeted cancer therapy.

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display

Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development

Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity.

Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways.

Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion

Late failure of a split-thickness skin graft in the setting of homozygous factor V Leiden mutation: a case report and correlative animal model from the Wound Etiology and Healing (WE-HEAL) study

Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression

Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

Omics-based molecular target and biomarker identification.

Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma.

Penbutolol: beta-adrenoceptor interaction and the time course of plasma concentrations explain its prolonged duration of action in man

Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements.

Pleiotrophin (PTN) Expression and Function and in the Mouse Mammary Gland and Mammary Epithelial Cells ⬇️

Pleiotrophin drives a prometastatic immune niche in breast cancer

Properties of agonist binding at the beta-adrenoceptor of the rat reticulocyte

Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells.

RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response

Receptor binding of propranolol is the missing link between plasma concentration kinetics and the effect-time course in man

Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs

Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex

Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells.

Ribozyme targeting of the growth factor pleiotrophin in established tumors: a gene therapy approach.

Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome

Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription

Serum levels of the angiogenic factor pleiotrophin in relation to disease stage in lung cancer patients.

Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer

Signal transduction pathways involved in the mitogenic activity of pleiotrophin. Implication of mitogen-activated protein kinase and phosphoinositide 3-kinase pathways

Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma

Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing Reveals Novel and Distinct mRNA Isoforms in Human Bone Marrow Cell Subpopulations.

Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells

Structure of the human heparin-binding growth factor gene pleiotrophin.

Superoxide modulates myogenic contractions of mouse afferent arterioles

Systemic morphine administration suppresses genes involved in antigen presentation

The efficacy of 9-cis retinoic acid in experimental models of cancer.

The nuclear coactivator amplified in breast cancer 1 maintains tumor-initiating cells during development of ductal carcinoma in situ

The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.

The potential role of the heparin-binding growth factor pleiotrophin in breast cancer.