List of works - Stefano Comai

A mass spectrometric investigation on the possible role of tryptophan and 7-hydroxytryptophan in melanogenesis

scientific article

A study of tryptophan metabolism via serotonin in ventricular cerebrospinal fluid in HIV-1 infection using a neuroendoscopic technique

scientific article published in March 2007

An investigation on the possible role of melatonin in melanogenesis

scientific article published in April 2006

An investigation on the role of 3-hydroxykynurenine in pigment formation by matrix-assisted laser desorption/ionization mass spectrometry

scientific article published in January 2004

Antidepressant combination versus antidepressants plus second-generation antipsychotic augmentation in treatment-resistant unipolar depression

scientific article

Antinociceptive properties of selective MT(2) melatonin receptor partial agonists

scientific article published on 7 July 2015

Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam

scientific article

Biomarkers in aggression

scientific article published on 11 September 2019

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

article

Centella asiatica (L.) urban from Nepal: Quali-quantitative analysis of samples from several sites, and selection of high terpene containing populations for cultivation

scholarly article by Anjana Devkota et al published February 2010 in Biochemical Systematics and Ecology

Changes in serum tryptophan during antiviral therapy with recombinant α-interferon in chronic hepatitis C

Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits

scientific article published on 26 August 2005

Differential Function of Melatonin MT and MT Receptors in REM and NREM Sleep

Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.

scientific article published in April 2018

Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking MT2 receptors

scientific article published on 01 April 2020

Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.

scientific article published on 19 October 2010

Effects of quetiapine and olanzapine in patients with psychosis and violent behavior: a pilot randomized, open-label, comparative study

scientific article

Endoscopic selective sampling of human ventricular CSF: a new perspective.

scientific article published on December 2004

Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review

scientific article

Essential oil of Lindera neesiana fruit: chemical analysis and its potential use in topical applications.

scientific article published on 6 July 2009

Franco Fraschini, MD, PhD (1932-2020)

scientific article published on 19 October 2020

Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder

scientific article published on 19 August 2019

High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe?

scientific article published on 02 May 2018

Importance of the dysregulation of the kynurenine pathway on cognition in schizophrenia: a systematic review of clinical studies

scientific article published in 2022

Influence of age on Cu/Zn-superoxide dismutase and indole 2,3-dioxygenase activities in rat tissues.

scientific article

Investigating the relationship between melatonin levels, melatonin system, microbiota composition and bipolar disorder psychopathology across the different phases of the disease

scientific article published on 09 December 2019

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

scientific article

Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.

scientific article published on 31 January 2015

Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle.

scientific article published on 17 May 2019

Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications, and perspectives

scientific article published on 25 April 2019

Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca2+ -CaMKII-CREB pathway in the ventrolateral preoptic nucleus

scientific article published on 14 June 2020

Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states

scientific article published on 7 January 2014

Menopause alters the metabolism of serum serotonin precursors and their correlation with gonadotropins and estradiol

scientific article published on 01 October 2007

Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder

scientific article

Non-protein (free and protein-bound) tryptophan content in cereal and legume seed flours

PM361. The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors

scientific article published on 27 May 2016

PT628. First in class melatonin MT2 receptors agonists for neuropathic pain.

scientific article

Phytochemical and antioxidant-related investigations on bark of Abies spectabilis (D. Don) Spach. from Nepal

scientific article published on 08 February 2012

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

scientific journal article

Protein and non-protein (free and protein-bound) tryptophan in legume seeds

Psychopathological and sociodemographic features in treatment-resistant unipolar depression versus bipolar depression: a comparative study.

scientific article

Quinoa: Protein and Nonprotein Tryptophan in Comparison with Other Cereal and Legume Flours and Bread

Reduced peripheral availability of tryptophan and increased activation of the kynurenine pathway and cortisol correlate with major depression and suicide.

scientific article published on 23 April 2018

Reduction of serum serotonin precursors after veralipride treatment for postmenopausal hot flushes

scientific article published on April 2010

Role of palmitoylethanolamide (PEA) in depression: Translational evidence

Search for melanoma markers in plasma and serum samples

scientific article published in January 2005

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.

scientific article published on February 2015

Serotonin Dysfunction, Aggressive Behavior, and Mental Illness: Exploring the Link Using a Dimensional Approach

scientific article published on 05 April 2017

Serum tryptophan and 5-hydroxytryptophan at birth and during post-partum days.

scientific article

Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep

scientific article published on 21 January 2019

Sleep-wake characterization of double MT₁/MT₂ receptor knockout mice and comparison with MT₁ and MT₂ receptor knockout mice

scientific article published on 16 January 2013

Study of tryptophan metabolism via serotonin in cerebrospinal fluid of patients with noncommunicating hydrocephalus using a new endoscopic technique.

scientific article published in August 2006

Targeting melatonin MT2 receptors: A novel pharmacological avenue for inflammatory and neuropathic pain.

scientific article published on 8 February 2017

The content of proteic and nonproteic (free and protein-bound) tryptophan in quinoa and cereal flours

The content of protein and non-protein (free and protein-bound) tryptophan in Theobroma cacao beans

The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats

scientific article

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors

scientific article (publication date: November 2016)

The protein profile of Theobroma cacao L. seeds as obtained by matrix-assisted laser desorption/ionization mass spectrometry

scientific article

The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology

scientific article published on February 2012

The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium

scientific article published on April 2012

The role of peptides and proteins in melanoidin formation

scientific article

Trace elements among a sample of prisoners with mental and personality disorders and aggression: correlation with impulsivity and ADHD indices

scientific article published on 05 October 2018

Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus

scientific article published on 17 January 2020

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

scientific article

Triterpene derivatives from Abies spectabilis leaves of Nepalese origin

scientific article published on 01 June 2011

Tryptophan in health and disease

scientific article published on 15 October 2019

Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits

scientific article published in December 2004

Tryptophan metabolism via serotonin in human CSF of different brain sites using a new neuroendoscopic technique

scholarly article by P. Longatti et al published November 2007 in International Congress Series

Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression

scientific article published on 23 April 2016

Two phenolic glycosides from Curculigo orchioides Gaertn

scientific article published on 11 March 2009

Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

scientific article published on January 2014

Valproate augmentation in a subgroup of patients with treatment-resistant unipolar depression

scientific article

Ventricular cerebrospinal fluid melatonin concentrations investigated with an endoscopic technique

scientific article published in March 2007

d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology.

scientific article

List of works by Stefano Comai

A mass spectrometric investigation on the possible role of tryptophan and 7-hydroxytryptophan in melanogenesis

A study of tryptophan metabolism via serotonin in ventricular cerebrospinal fluid in HIV-1 infection using a neuroendoscopic technique

An investigation on the possible role of melatonin in melanogenesis

An investigation on the role of 3-hydroxykynurenine in pigment formation by matrix-assisted laser desorption/ionization mass spectrometry

Antidepressant combination versus antidepressants plus second-generation antipsychotic augmentation in treatment-resistant unipolar depression

Antinociceptive properties of selective MT(2) melatonin receptor partial agonists

Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam

Biomarkers in aggression

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

Centella asiatica (L.) urban from Nepal: Quali-quantitative analysis of samples from several sites, and selection of high terpene containing populations for cultivation

Changes in serum tryptophan during antiviral therapy with recombinant α-interferon in chronic hepatitis C

Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits

Differential Function of Melatonin MT and MT Receptors in REM and NREM Sleep

Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.

Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking MT2 receptors

Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.

Effects of quetiapine and olanzapine in patients with psychosis and violent behavior: a pilot randomized, open-label, comparative study

Endoscopic selective sampling of human ventricular CSF: a new perspective.

Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review

Essential oil of Lindera neesiana fruit: chemical analysis and its potential use in topical applications.

Franco Fraschini, MD, PhD (1932-2020)

Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder

High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe?

Importance of the dysregulation of the kynurenine pathway on cognition in schizophrenia: a systematic review of clinical studies

Influence of age on Cu/Zn-superoxide dismutase and indole 2,3-dioxygenase activities in rat tissues.

Investigating the relationship between melatonin levels, melatonin system, microbiota composition and bipolar disorder psychopathology across the different phases of the disease

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.

Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle.

Melatonin MT1 receptor as a novel target in neuropsychopharmacology: MT1 ligands, pathophysiological and therapeutic implications, and perspectives

Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca2+ -CaMKII-CREB pathway in the ventrolateral preoptic nucleus

Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states

Menopause alters the metabolism of serum serotonin precursors and their correlation with gonadotropins and estradiol

Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder

Non-protein (free and protein-bound) tryptophan content in cereal and legume seed flours

PM361. The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors

PT628. First in class melatonin MT2 receptors agonists for neuropathic pain.

Phytochemical and antioxidant-related investigations on bark of Abies spectabilis (D. Don) Spach. from Nepal

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

Protein and non-protein (free and protein-bound) tryptophan in legume seeds

Psychopathological and sociodemographic features in treatment-resistant unipolar depression versus bipolar depression: a comparative study.

Quinoa: Protein and Nonprotein Tryptophan in Comparison with Other Cereal and Legume Flours and Bread

Reduced peripheral availability of tryptophan and increased activation of the kynurenine pathway and cortisol correlate with major depression and suicide.

Reduction of serum serotonin precursors after veralipride treatment for postmenopausal hot flushes

Role of palmitoylethanolamide (PEA) in depression: Translational evidence

Search for melanoma markers in plasma and serum samples

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.

Serotonin Dysfunction, Aggressive Behavior, and Mental Illness: Exploring the Link Using a Dimensional Approach

Serum tryptophan and 5-hydroxytryptophan at birth and during post-partum days.

Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep

Sleep-wake characterization of double MT₁/MT₂ receptor knockout mice and comparison with MT₁ and MT₂ receptor knockout mice

Study of tryptophan metabolism via serotonin in cerebrospinal fluid of patients with noncommunicating hydrocephalus using a new endoscopic technique.

Targeting melatonin MT2 receptors: A novel pharmacological avenue for inflammatory and neuropathic pain.

The content of proteic and nonproteic (free and protein-bound) tryptophan in quinoa and cereal flours

The content of protein and non-protein (free and protein-bound) tryptophan in Theobroma cacao beans

The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors

The protein profile of Theobroma cacao L. seeds as obtained by matrix-assisted laser desorption/ionization mass spectrometry

The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology

The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium

The role of peptides and proteins in melanoidin formation

Trace elements among a sample of prisoners with mental and personality disorders and aggression: correlation with impulsivity and ADHD indices

Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Triterpene derivatives from Abies spectabilis leaves of Nepalese origin

Tryptophan in health and disease

Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits

Tryptophan metabolism via serotonin in human CSF of different brain sites using a new neuroendoscopic technique

Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression

Two phenolic glycosides from Curculigo orchioides Gaertn

Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

Valproate augmentation in a subgroup of patients with treatment-resistant unipolar depression

Ventricular cerebrospinal fluid melatonin concentrations investigated with an endoscopic technique

d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology.