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List of works by Carsten Wrenger

Advances and Challenges in Drug Design of PPARδ Ligands.

scientific article

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum

scientific article (publication date: December 2007)

Aptamers: novel molecules as diagnostic markers in bacterial and viral infections?

scientific article

Aspartate aminotransferase: bridging carbohydrate and energy metabolism in Plasmodium falciparum.

scientific article published on March 2012

Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target.

scientific article published on 25 March 2008

Chemical and genetic validation of thiamine utilization as an antimalarial drug target

scientific article published on January 2013

Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum.

scientific article published on 22 June 2016

Crystallization and preliminary X-ray diffraction of malate dehydrogenase from Plasmodium falciparum.

scientific article published on 23 May 2012

Cytometric quantification of singlet oxygen in the human malaria parasite Plasmodium falciparum

scientific article published on 26 June 2012

DXS as a target for structure-based drug design

scientific article published on 21 June 2017

Disease-specific biomarker discovery by aptamers

scientific article published in September 2009

Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target Validation

scientific article published on 31 January 2016

Drug discovery for infectious agents causing neglected diseases

scientific article published on 01 January 2014

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

scientific article

HDL proteome remodeling associates with COVID-19 severity

scientific article published on 31 October 2021

Harnessing the helminth secretome for therapeutic immunomodulators.

scientific article published on 15 July 2014

Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum

scientific article (publication date: September 2004)

Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.

scientific article published on 21 February 2018

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

scientific article published on 22 January 2018

In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase

scientific article (publication date: 17 March 2000)

In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum

scientific article published on 5 April 2012

Indole-3-glyoxyl tyrosine: synthesis and antimalarial activity against Plasmodium falciparum

scientific article published on 27 March 2019

Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes

scientific article published on 04 March 2020

Insights in chloroquine action: perspectives and implications in Malaria and COVID-19

scientific article published on 19 July 2020

Insights into the genome and secretome of Fusarium metavorans DSM105788 by cultivation on agro-residual biomass and synthetic nutrient sources

scientific article published on 20 March 2021

Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum

scientific article published on 18 November 2019

MRSA infections: from classical treatment to suicide drugs.

scientific article published on January 2014

Melatonin activate FIS1, DYN1 and DYN2 Plasmodium falciparum related-genes for mitochondria fission: mitoemerald-GFP as a tool to visualize mitochondria structure.

scientific article published on 26 February 2018

Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?

scientific article published on January 2014

Mobility of the conserved glycine 155 is required for formation of the active plasmodial Pdx1 dodecamer.

scientific article published on 9 March 2009

Molecular Modeling Applied to Nucleic Acid-Based Molecule Development

article

Molecular Target Validation of Aspartate Transcarbamoylase from Plasmodium falciparum by Torin 2

scientific article published on 12 March 2020

Natural products as a source for treating neglected parasitic diseases

scientific article published on 6 February 2013

Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro

scientific article published on 25 April 2018

Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum

scientific article published on 28 February 2019

On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity

scientific article published on 13 December 2017

Oxidative stress control by apicomplexan parasites

scientific article

Plasmodium falciparum GFP-E-NTPDase expression at the intraerythrocytic stages and its inhibition blocks the development of the human malaria parasite

scientific article (publication date: 11 March 2017)

Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum

scientific article

Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum.

scientific article

Purification, crystallization and preliminary X-ray diffraction analysis of ThiM from Staphylococcus aureus.

scientific article published on 25 March 2011

Purification, crystallization and preliminary X-ray diffraction analysis of pyridoxal kinase from Plasmodium falciparum (PfPdxK).

scientific article published on 25 October 2014

Purification, crystallization and preliminary X-ray diffraction analysis of the thiaminase type II from Staphylococcus aureus

scientific article published on 21 December 2010

Recognition of biomarkers and cell-specific molecular signatures: aptamers as capture agents

scientific article published on May 2009

Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum

scientific article published on 11 January 2010

Specific inhibition of the aspartate aminotransferase of Plasmodium falciparum

scientific article

Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases

scientific article published on 19 November 2013

Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections

scientific article

Studies of Staphylococcus aureus FabI inhibitors: fragment-based approach based on holographic structure-activity relationship analyses

scientific article published on 27 January 2017

Targeting the Plasmodium falciparum Plasmepsin V by ligand-based virtual screening

scientific article published on 01 November 2018

Targeting the vitamin biosynthesis pathways for the treatment of malaria

scientific article published on May 2013

The Plasmodium falciparum bifunctional ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase, enables a well balanced polyamine synthesis without domain-domain interaction.

scientific article published on 4 June 2001

The antioxidative effect of de novo generated vitamin B6 in Plasmodium falciparum validated by protein interference

scientific article published on April 2012

The assembly of the plasmodial PLP synthase complex follows a defined course

scientific article

The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine

scientific article (publication date: December 2006)

The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways

scientific article (publication date: July 2004)

The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs

scientific article published on December 2000

The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels

scientific article

Trafficked Proteins-Druggable in Plasmodium falciparum?

scientific article published on 28 April 2013

Vitamin B metabolism in Plasmodium falciparum as a source of drug targets

scientific article published in January 2010

Vitamin B1 and B6 in the malaria parasite: requisite or dispensable?

scientific article published on 11 January 2008

Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine

scientific article published on January 2006

Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?

scientific article published on 9 January 2014

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