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List of works by Sylvie Lesage

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

scientific article

A cell death pathway induced by antibody-mediated cross-linking of CD45 on lymphocytes

scientific article published on January 2003

A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells

scientific article published on 19 August 2012

A transcriptome-based approach to identify functional modules within and across primary human immune cells

scientific article published on 29 May 2020

Abnormal differentiation of B cells and megakaryocytes in Roifman syndrome.

scientific article published on 29 January 2018

Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes

scientific article published on 15 January 2009

Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis

scientific article published on 03 December 2020

Aire regulates negative selection of organ-specific T cells

scientific article (publication date: April 2003)

An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.

scientific article published on 14 July 2017

An orthologous non-MHC locus in rats and mice is linked to CD4(+) and CD8(+) T-cell proportion

scientific article published on 25 May 2017

Antagonism between Nur77 and glucocorticoid receptor for control of transcription.

scientific article published on October 1997

Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12.

scientific article published on 24 January 2015

BIM determines the number of merocytic dendritic cells, a cell type that breaks immune tolerance.

scientific article published on 13 May 2018

BMP9 signaling promotes the normalization of tumor blood vessels

scientific article published on 10 February 2020

Biomarker-guided stratification of autoimmune patients for biologic therapy

scientific article published on 17 October 2017

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia

scientific article published on 01 September 2020

CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway

scientific article published on 01 November 1997

Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross

scientific article published on 26 December 2018

Cutting Edge: CD47 Controls the In Vivo Proliferation and Homeostasis of Peripheral CD4+CD25+Foxp3+ Regulatory T Cells That Express CD103

scientific article published on 01 October 2008

Cutting edge: genetic characterization of IFN-producing killer dendritic cells.

scientific article

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

scientific article published on 28 September 2016

Double-Negative T Cell Levels Correlate with Chronic Graft-versus-Host Disease Severity

scientific article published on 19 September 2018

Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD mice

scientific article published on 26 March 2015

Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs.

scientific article published on 9 November 2006

FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation

scientific article published on 04 September 2020

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

scientific article

Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

scientific article published on 01 November 2019

Functional characterization of CaVα2δ mutations associated with sudden cardiac death

scientific journal article

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

scientific article

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

scientific article published in December 2004

Genes Outside the Major Histocompatibility Complex Locus Are Linked to the Development of Thyroid Autoantibodies and Thyroiditis in NOD.H2h4 Mice

scientific article published on 17 January 2017

Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion

scientific article published on 25 April 2018

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

scientific article

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

scientific article published on 21 March 2016

Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties

scientific article published on 28 August 2019

High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies

scientific article published on 18 January 2017

Humoral responses to the measles, mumps and rubella vaccine are impaired in Leigh Syndrome French Canadian patients

scientific article published on 21 October 2020

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

scientific article published on 17 February 2016

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice

article

Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity

scientific article published on 7 January 2016

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

scientific article

Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer

scientific article published on 24 January 2013

Implication of the CD47 pathway in autoimmune diabetes

scientific article published on 06 February 2010

Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways

scientific article published on 31 May 2019

Induction of thymocyte deletion by purified single peptide/major histocompatibility complex ligands

scientific article published on 01 September 1997

Interleukin-10 limits the expansion of immunoregulatory CD4− CD8− T cells in autoimmune-prone non-obese diabetic mice

scientific article published on 06 July 2010

Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis

scientific article published on 11 November 2020

MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.

scientific article published on 9 December 2016

MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells

scientific article published on 20 May 2020

Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes

scientific article

Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity

scientific article published on 27 May 2020

Molecular and genetic parameters defining T-cell clonal selection

scientific article published on 19 October 2010

NK Cell Proportion and Number Are Influenced by Genetic Loci on Chromosomes 8, 9, and 17.

scientific article

Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice.

scientific article published on 18 April 2013

Novel Dimeric Nur77 Signaling Mechanism in Endocrine and Lymphoid Cells ⬇️

scientific article published on October 1, 1997

On-chip refractive index cytometry for whole-cell deformability discrimination

scientific article published on 01 January 2019

Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation

scientific article published on 21 February 2012

Restoring T Cell Homeostasis After Allogeneic Stem Cell Transplantation; Principal Limitations and Future Challenges.

scientific article

Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells.

scientific article published on 11 December 2013

Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus.

scientific article

Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response

scientific article published on 20 August 2014

Spinal cord compression of dual etiology, multiple myeloma and spinal tuberculosis

scientific article published on 01 February 2002

Starting Your Independent Research Laboratory ⬇️

scientific article published in August 2021

T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form

scientific article published in April 2003

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.

scientific article

The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility

scientific article published on 26 April 2013

The Importance of Dendritic Cells in Maintaining Immune Tolerance.

scientific article published on March 2017

The Potential Causes of Cystic Fibrosis-Related Diabetes ⬇️

journal article from 'Frontiers in Endocrinology' published in 2021

The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation

scientific article

The mouse idd2 locus is linked to the proportion of immunoregulatory double-negative T cells, a trait associated with autoimmune diabetes resistance.

scientific article published on 27 August 2014

The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation

scientific article published on 08 July 2019

The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death.

scientific article

The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7.

scientific article published on 30 April 2012

Thymic selection generates T cells expressing self-reactive TCRs in the absence of CD45.

scientific article published in September 2000

Unusual selection and peripheral homeostasis for immunoregulatory CD4(-)  CD8(-) T cells.

scientific article

Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis ⬇️

journal article from 'Frontiers in Immunology' published in 2021

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