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List of works by Matthew T O'Neill

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

scientific article published on 18 November 2015

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P position of PEXEL peptidomimetics

Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.

scientific article published on 16 March 2016

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

scientific article published on February 2016

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

scientific article (publication date: July 2014)

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

scientific article

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax

scientific article published on 11 September 2014

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