List of works by Mina Bissell

14-3-3σ stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion

scientific article published on 25 September 2013

184AA3: a xenograft model of ER+ breast adenocarcinoma

scientific article

A Functionally Robust Phenotypic Screen that Identifies Drug Resistance-associated Genes Using 3D Cell Culture

scientific article published on 01 November 2018

A human breast cell model of preinvasive to invasive transition.

scientific article published on March 2008

A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells.

scientific article

ATM suppresses SATB1-induced malignant progression in breast epithelial cells

scientific article

Addressing overdiagnosis and overtreatment in cancer: a prescription for change

scientific article

Alterations in Progesterone Receptor Isoform Balance in Normal and Neoplastic Breast Cells Modulates the Stem Cell Population

scientific article published on 11 September 2020

An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity

scientific article

An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival

scientific article

Apical polarity in three-dimensional culture systems: where to now?

scientific article

Architecture Is the Message: The role of extracellular matrix and 3-D structure in tissue-specific gene expression and breast cancer

scientific article published on 01 October 2007

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

scientific article

Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland

scientific article

Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype

scholarly article

Balancing work and life: a conversation with Mina Bissell. Interviewed by Majlinda Lako and Susan Daher

scientific article published in August 2009

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

scientific article published on January 2009

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

scientific article published on June 2008

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

scientific article

Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia

scientific article

Breast cancer by proxy: can the microenvironment be both the cause and consequence?

scientific article published on 16 December 2008

Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin

scientific article

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8(+) T cells

scientific article

Cancer stem cells in breast and prostate: Fact or fiction?

scientific article published on 13 June 2019

Cancer. Respect thy neighbor!

scientific article published in February 2004

Caveolin-1: would-be Achilles' heel of tumor microenvironment?

scientific article published on 15 October 2011

Cell Biology: A Love Affair ⬇️

scientific article published on November 15, 2010

Cell shape regulates global histone acetylation in human mammary epithelial cells

scientific article

Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset.

scientific article

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

scientific article

Chromatin organization measured by AluI restriction enzyme changes with malignancy and is regulated by the extracellular matrix and the cytoskeleton

scientific article

Coherent angular motion in the establishment of multicellular architecture of glandular tissues

scientific article

Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells

scientific article

Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening

scientific article published on 13 October 2011

Communication between the cell membrane and the nucleus: role of protein compartmentalization

scientific article

Constructing three-dimensional models to study mammary gland branching morphogenesis and functional differentiation

scientific article published on 10 May 2012

Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

scientific article

Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins

scientific article

Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture.

scientific article published on 5 August 2016

Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer.

scientific article

Delivering the message: epimorphin and mammary epithelial morphogenesis

scientific article

Depletion of nuclear actin is a key mediator of quiescence in epithelial cells

scientific article

Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery

scientific article

Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring.

scientific article

Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity

scientific article published on 04 August 2009

Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme

scientific article published on May 2007

Epimorphin is a novel regulator of the progesterone receptor isoform-a

scientific article published on 18 July 2013

Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma.

scientific article published in October 2005

Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia

scientific article

Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma

scientific article published on February 2003

Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases

scientific article published on February 2012

Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice

scientific article published on January 2009

Evaluation of normalization methods for cDNA microarray data by k-NN classification

scientific article

Evidence for a stem cell hierarchy in the adult human breast

scientific article

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

scientific article

Extracellular localization of epimorphin/syntaxin-2.

scientific article published on October 2007

Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging

scientific article

Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress.

scientific article

Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors

scientific article

Extracellular vesicle and particle biomarkers define multiple human cancers

journal article published in 2020

FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach

scientific article published on 26 October 2016

FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice

scientific article

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells

scientific article published on 06 July 2018

Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?

scientific article

From single cells to biology

scientific article published on 21 March 2012

Gene expression in the third dimension: the ECM-nucleus connection

scientific article

Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer

scientific article

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

scientific article published on 28 September 2020

Goodbye flat biology - time for the 3rd and the 4th dimensions

scientific article published on January 2017

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

scientific article

Heeding a mentor's advice: a lesson in persistence

scientific article published in December 2011

Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2

scientific article

Homeostasis in the breast: it takes a village

scientific article

Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis

scientific article published on 07 January 2009

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

scientific article

IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells

scientific article

Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment.

scientific article

Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes

scientific article published on 12 December 2011

Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance

scientific article published in April 2012

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

scientific article

Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

scientific article published on 10 March 2009

Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context

scientific article published on 17 May 2016

Integrative biology editorial 2010. One year and beyond: the excitement continues

scientific article published on 16 December 2009

Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells

scientific article published on 05 May 2009

Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response. ⬇️

scientific article published on January 2012

Introduction: the role of myoepithelial cells in integration of form and function in the mammary gland

scientific article published on 01 July 2005

Ionizing radiation induces heritable disruption of epithelial cell interactions

scientific article

Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition

scientific article

Iron Supplementation Eliminates Antagonistic Interactions Between Root-Associated Bacteria

scientific article published on 22 July 2020

Is CD133 a marker of metastatic colon cancer stem cells?

scientific article published on June 2008

Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties

scientific article

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

scientific article published on 09 October 2008

Laminin regulates PI3K basal localization and activation to sustain STAT5 activation.

scientific article

Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs.

scientific article published on 21 March 2018

Laminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6.

scientific article

Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues

scientific article

Localization of plasma membrane and secretory calcium pumps in the mammary gland.

scientific article published on 10 March 2008

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits

scientific article

Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha

scientific article published on January 2004

Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14.

scientific article

Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase.

scientific article published on 17 March 2004

Mammary gland development: cell fate specification, stem cells and the microenvironment

scientific article

Matrix metalloproteinase-induced genomic instability

scientific article

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.

scholarly article

Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

scientific article

Metastasis: Pathways of parallel progression

scientific article

Mina Bissell: Context is everything. [An interview by Ben Short].

scientific article published in May 2009

Mina Bissell: Experiments that point to a new understanding of cancer

TEDGlobal 2012

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age

article

Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation

scientific article

Modeling mammary gland morphogenesis as a reaction-diffusion process

scientific article published in January 2004

Modeling tissue-specific signaling and organ function in three dimensions

scientific article

Modelling breast cancer requires identification and correction of a critical cell lineage-dependent transduction bias

scientific article published on 21 April 2015

Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture

scientific article

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

scientific article

Myoepithelial cells: good fences make good neighbors

scientific article

Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia

scientific article

NF-kappaB links oestrogen receptor signalling and EMT

scientific article published on 01 April 2007

NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals

scientific article

Network analysis of breast cancer progression and reversal using a tree-evolving network algorithm

scientific article (publication date: July 2014)

New insight into the role of MMP14 in metabolic balance

scientific article published on 13 July 2016

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

scientific article

Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis

scientific article published on 05 August 2016

Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.

scientific article

Of microenvironments and mammary stem cells

scientific article

Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype

scientific article published on January 2014

Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype

scientific article published on 18 November 2013

Order and disorder: the role of extracellular matrix in epithelial cancer

scientific article

Organoids: A historical perspective of thinking in three dimensions

scientific article published on 28 December 2016

Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets.

scientific article

Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules.

scientific article published on 04 April 2013

Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ

scientific article published on 13 September 2019

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts

scientific article

Photonic gene circuits by optically addressable siRNA-Au nanoantennas

scientific article

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells

scientific article

Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1

scientific article

Polo-like kinase 1 is involved in invasion through extracellular matrix

scientific article published on December 2007

Pre-metastatic niches: organ-specific homes for metastases.

scientific article published on 17 March 2017

Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Conference Summary Statement

scientific article published on 01 January 2004

Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets

scientific article

Proliferation and polarity in breast cancer: untying the Gordian knot

scientific article

Prostate cancer in bone: importance of context for inhibition of matrix metalloproteinases

scientific article

Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells.

scientific article published on September 2004

Q&A: Mina Bissell on tumors as organs

scientific article published in January 2013

Quis custodiet ipsos custodies: who watches the watchmen?

scientific article

Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo

scientific article

Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells

scientific article

Regulation of in situ to invasive breast carcinoma transition

scientific article published on May 2008

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

scientific article

Reproducibility: The risks of the replication drive

scientific article published in November 2013

Reprogramming stem cells is a microenvironmental task

scholarly article

Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules

scientific article

Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair

scientific article

Rhizobacteria Mediate the Phytotoxicity of a Range of Biorefinery-Relevant Compounds

scientific article published on 26 July 2019

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells

scientific article

Self-organization of engineered epithelial tubules by differential cellular motility

scholarly article

Single proteins might have dual but related functions in intracellular and extracellular microenvironments

scientific article published on 04 February 2009

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

scientific article published in September 2003

SnapShot: Branching Morphogenesis

scientific article

SnoN regulates mammary gland alveologenesis and onset of lactation by promoting prolactin/Stat5 signaling

scientific article

Sorting out the FACS: a devil in the details

scientific article published on 01 March 2014

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors

scientific article

Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1.

scientific article published on 13 February 2015

Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function.

scientific article published on January 2009

Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity

scientific article published on 22 July 2020

Targeting TACE-dependent EGFR ligand shedding in breast cancer

scientific article published on 11 January 2007

Targeting the tumor microenvironment

scientific article

The Ecology of Tumors: By perturbing the microenvironment, wounds and infection may be key to tumor development.

scientific article

The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium

scientific article

The dominance of the microenvironment in breast and ovarian cancer

scientific article

The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90β

scientific article published on April 2013

The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells

scientific article

The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis

scientific article published on 31 December 2010

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

scientific article published on June 2007

The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer

scientific article

The not-so-sweet side of sugar: Influence of the microenvironment on the processes that unleash cancer

scientific article published on 09 September 2020

The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis

scientific article

The organizing principle: microenvironmental influences in the normal and malignant breast

scientific article

The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient outcome

scientific article published on 12 August 2016

The perivascular niche regulates breast tumour dormancy.

scientific article published on 02 June 2013

The tumor microenvironment is a dominant force in multidrug resistance.

scientific article published on 13 February 2012

The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin

scientific article published on 21 September 2011

Thinking in three dimensions: discovering reciprocal signaling between the extracellular matrix and nucleus and the wisdom of microenvironment and tissue architecture

scientific article

Three-dimensional culture models of normal and malignant breast epithelial cells

scientific article

Three-dimensional culture of human breast epithelial cells: the how and the why.

scientific article published on January 2013

Three-dimensional cultures of mouse mammary epithelial cells

scientific article published on January 2013

Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression

scientific article

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

scientific article published on June 2009

Tissue architecture: the ultimate regulator of breast epithelial function

scientific article

Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures

scientific article

To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia

scientific article

Toward plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models

scientific article published on January 2013

Training the next generation of biomedical investigators in glycosciences

scientific article published on February 2016

Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling.

scientific article published on 21 March 2018

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.

scientific article published on January 2013

Tumor engineering: the other face of tissue engineering

scientific article

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.

scientific article published on 27 March 2012

Tumor reversion: Correction of malignant behavior by microenvironmental cues ⬇️

scientific article published on December 10, 2003

Tumour exosome integrins determine organotropic metastasis.

scientific article published on 28 October 2015

Two molecular cytogenetic views of breast cancer.

scientific article published on 12 March 2000

Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells

scientific article

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

scientific article

Zena Werb (1945-2020)

scientific article

Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon

scientific article published on 29 October 2020

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

scientific article published on September 2002

hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis

scientific article published on 15 June 2018

p53-dependent integration of telomere and growth factor deprivation signals

scholarly article

β1 and β4 integrins: from breast development to clinical practice

scientific article

β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

scientific article published on 31 August 2011

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