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List of works by Arne Holmgren

1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity

scientific article published on 01 February 1995

A New Mechanism of Action for the Anticancer Drug Mitomycin C: Mechanism-Based Inhibition of Thioredoxin Reductase ⬇️

scientific article published on June 25, 2012

A Pro to His mutation in active site of thioredoxin increases its disulfide-isomerase activity 10-fold. New refolding systems for reduced or randomly oxidized ribonuclease ⬇️

scientific article published on May 5, 1992

A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins.

scientific article published on 16 May 2007

A mutant thioredoxin from Escherichia coli tsnC 7007 that is nonfunctional as subunit of phage T7 DNA polymerase

scientific article published on 01 March 1981

A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase

scientific article published on 12 August 2002

An unusual mode of iron–sulfur-cluster coordination in a teleost glutaredoxin ⬇️

scientific article published on June 10, 2013

Ascorbate and endocytosed Motexafin gadolinium induce lysosomal rupture ⬇️

scientific article published on April 13, 2011

Assignment of the 15N NMR spectra of reduced and oxidized Escherichia coli thioredoxin

scientific article

Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold

scientific article published in August 1989

Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori

scientific article

Bacillus anthracis thioredoxin systems, characterization and role as electron donors for ribonucleotide reductase

scientific article published on 25 September 2012

Bacterial thioredoxin and thioredoxin reductase as mediators for epigallocatechin 3-gallate-induced antimicrobial action

scientific article

Cellular Redox Systems Impact the Aggregation of Cu,Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis

scientific article published on 3 June 2016

Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems

scientific article

Characterization by 1H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild-type protein.

scientific article

Characterization of Escherichia coli Null Mutants for Glutaredoxin 2 ⬇️

scientific article published on December 10, 2001

Characterization of bacteriophage T7 DNA polymerase purified to homogeneity by antithioredoxin immunoadsorbent chromatography

scientific article published on 01 March 1981

Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor

scientific article

Characterization of the redox properties of poplar glutaredoxin

scientific article published in February 2003

Chronic elevation of plasma thioredoxin: inhibition of chemotaxis and curtailment of life expectancy in AIDS

scholarly article

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

scientific article published on 27 October 2009

Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms

scientific article

Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using 15N NMR relaxation measurements.

scientific article

Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes ⬇️

scientific article published on January 4, 2011

EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide

scientific article published in May 2001

Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems

scientific article

Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

scientific article

Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction

scientific article

Effect of disulfide bridge formation on the NMR spectrum of a protein: studies on oxidized and reduced Escherichia coli thioredoxin.

scientific article

Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57.

scientific article

Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase

scientific article

Elevation of plasma thioredoxin levels in HIV-infected individuals

scientific article published on 01 April 1996

Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy

scholarly article published in Nature Structural & Molecular Biology

Expression analysis of the nrdHIEF operon from Escherichia coli. Conditions that trigger the transcript level in vivo

scientific article

Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS.

scientific article published on 11 March 2002

Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoforms

scientific article

From selenium to selenoproteins: synthesis, identity, and their role in human health

scientific article

Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal

scientific article

Glutaredoxin accelerates glutathione-dependent folding of reduced ribonuclease A together with protein disulfide-isomerase

scientific article published on 01 April 1995

Glutaredoxin from calf thymus. Purification to homogeneity

scientific article published on 01 June 1982

Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients

scientific article published on 10 June 2015

Glutaredoxin-3 from Escherichia coli. Amino acid sequence, 1H AND 15N NMR assignments, and structural analysis

scientific article published on 01 March 1996

Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency

scientific journal article

Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system

scientific article (publication date: February 2004)

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

scientific article published on 29 September 2017

Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose

scientific article published on 13 September 2012

Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2-R1-dependent ribonucleotide reductase

scientific article published on 02 July 2019

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems

scientific article

High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin

scientific article

High-resolution structures of oxidized and reduced thioredoxin reductase from Helicobacter pylori

scientific article

Histopathology vs. inhibition of the thioredoxin system of mercury-exposed fish

scholarly article by Cristina Carvalho et al published June 2012 in Toxicology Letters

Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase

scientific article

Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity.

scientific article

Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols

scientific article published on 01 May 1995

Immunochemical characterization and tissue distribution of glutaredoxin (thioltransferase) from calf.

scientific article published in December 1993

Immunoelectron microscopic localization of glutaredoxin and thioredoxin in Escherichia coli cells

scientific article published on 01 October 1981

Immunohistochemical localization of thioredoxin and thioredoxin reductase in adult rats

scientific article published on 01 July 1985

Immunolocalization of thioredoxin and glutaredoxin in mammalian hypophysis

scientific article published in May 1992

In vivo transcription of nrdAB operon and of grxA and fpg genes is triggered in Escherichia coli lacking both thioredoxin and glutaredoxin 1 or thioredoxin and glutathione, respectively

scientific article published on July 1998

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity

scientific article published on April 2006

Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions

scientific article

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

scientific article published in Scientific Reports

Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells

article

Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability

scientific article published in December 2008

Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.

scientific article

MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

scientific article published on 16 April 2018

Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue

scientific article published on 01 May 1998

Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd).

scientific article

Mercury and selenium effects on HepG2 cells: TrxR activity and expression levels

scholarly article by Cristina Carvalho et al published June 2012 in Toxicology Letters

Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase

scientific article published on 03 May 2009

Mimicking the active site of protein disulfide-isomerase by substitution of proline 34 in Escherichia coli thioredoxin

scientific article published on 01 May 1991

Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems

scientific article published on 7 February 2018

Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli

scientific article published on 18 April 2005

Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase

scientific journal article

Motion of aromatic side chains, picosecond fluorescence, and internal energy transfer in Escherichia coli thioredoxin studied by site-directed mutagenesis, time-resolved fluorescence spectroscopy, and molecular dynamics simulations

scientific article published on October 1991

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

scientific article published on 15 November 2010

NADPH-dependent and -independent Disulfide Reductase Systems

scientific article published on 30 March 2018

NMR structure of oxidized glutaredoxin 3 from Escherichia coli

scientific article

New thioredoxins and glutaredoxins as electron donors of 3'-phosphoadenylylsulfate reductase

scientific article published on 01 March 1999

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release

scientific article

Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1.

scientific article

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

scientific article

Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver.

scientific article

Physiological functions of thioredoxin and thioredoxin reductase

scientific article (publication date: October 2000)

Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes

scientific article published on 9 July 2013

Probing the chemistry of thioredoxin catalysis with force

scientific article

Protein folding drives disulfide formation

scientific article published on November 2012

Protein levels of Escherichia coli thioredoxins and glutaredoxins and their relation to null mutants, growth phase, and function

scientific article published on 13 March 2002

Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1.

scientific article

Proton sharing between cysteine thiols in Escherichia coli thioredoxin: implications for the mechanism of protein disulfide reduction.

scientific article

Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional 1H NMR.

scientific article

Purification, crystallization and preliminary crystallographic data for rat cytosolic selenocysteine 498 to cysteine mutant thioredoxin reductase

scientific article

Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.

scientific article published on April 1998

Reactivity of glutaredoxins 1, 2 and 3 from Escherichia coli and protein disulfide isomerase towards glutathionyl-mixed disulfides in ribonuclease A.

scientific article published in January 1999

Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction.

scientific article

Real-time kinetics of the interaction between the two subunits, Escherichia coli thioredoxin and gene 5 protein of phage T7 DNA polymerase

scientific article published on 31 March 2003

Reconstitution of Escherichia coli thioredoxin from complementing peptide fragments obtained by cleavage at methionine-37 or arginine-73 ⬇️

scientific article published on February 25, 1975

Redox properties and evolution of human glutaredoxins

scientific article

Redox regulation of 3'-phosphoadenylylsulfate reductase from Escherichia coli by glutathione and glutaredoxins

scientific article

Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residues

scientific article published on 10 June 2008

Replacement of Trp inEscherichia coliThioredoxin by Site-directed Mutagenesis Affects Thermodynamic Stability but Not Function

scientific article published in Journal of Biological Chemistry

Requirements for the different cysteines in the chemotactic and desensitizing activity of human thioredoxin

scientific article

Resonance assignment and structural analysis of acid denatured E. coli [U-15N]-glutaredoxin 3: use of 3D 15N-HSQC-(TOCSY-NOESY)-15N-HSQC

scientific article published on 01 January 1996

Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential

scientific article

Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron

scientific article published on 01 July 1996

Selenoprotein Gene Nomenclature

scientific article published on 19 September 2016

Selenoproteins

scientific article

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide

scientific article

Solution structure and biophysical properties of MqsA, a Zn-containing antitoxin from Escherichia coli

scientific article

Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases

scientific article

Stimulation of Fe-S cluster insertion into apoFNR by Escherichia coli glutaredoxins 1, 2 and 3 in vitro

scientific article

Structural basis for the thioredoxin-like activity profile of the glutaredoxin-like NrdH-redoxin from Escherichia coli

scientific article

Structural differences between oxidized and reduced thioredoxin monitored by two-dimensional 1H NMR spectroscopy

scientific article published in February 1988

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

scientific article

Substitution of the conserved tryptophan 31 in Escherichia coli thioredoxin by site-directed mutagenesis and structure-function analysis.

scientific article published in March 1991

Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production.

scientific article

Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections.

scientific article published on 12 June 2017

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

scientific article

The Levels of Ribonucleotide Reductase, Thioredoxin, Glutaredoxin 1, and GSH Are Balanced in Escherichia coli K12

scientific article published in Journal of Biological Chemistry

The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43.

scientific article published on 17 February 2007

The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase

scientific article published on 01 November 1994

The thioredoxin antioxidant system ⬇️

scientific article published on July 27, 2013

The thioredoxin superfamily in oxidative protein folding

scientific article published on 06 March 2014

The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina

scientific article published on 11 March 2009

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system

scientific article published on 15 December 2006

Thiols decrease cytokine levels and down-regulate the expression of CD30 on human allergen-specific T helper (Th) 0 and Th2 cells

scientific article

Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by the glutaredoxin system

scientific article published on 23 September 2013

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

scientific article published on 31 March 2017

Thioredoxin System in Cell Death Progression ⬇️

scientific article published on June 11, 2012

Thioredoxin and related molecules--from biology to health and disease

scientific article

Thioredoxin and thioredoxin reductase: current research with special reference to human disease

scientific article

Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity

scientific article published on 7 January 2008

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

scientific article

Thioredoxin reductase-dependent insulin disulfide reduction by phage T7 DNA polymerase reflects dissociation of the enzyme into subunits.

scientific article published in October 1989

Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells

scientific article

Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy.

scientific article published in May 1990

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

scientific article

Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway

scientific article

Transcriptional Regulation of Glutaredoxin and Thioredoxin Pathways and Related Enzymes in Response to Oxidative Stress

scientific article published in Journal of Biological Chemistry

Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma

scientific article published on 01 December 2000

Truncated thioredoxin: physiological functions and mechanism

scientific article published on February 2004

Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.

scientific article published on October 1994

Ultrastructural demonstration of thioredoxin and thioredoxin reductase in rat hepatocytes

scientific article published on 01 August 1988

Vertebrate-specific glutaredoxin is essential for brain development

scientific article published on 2 December 2011

Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells

scientific article published on 15 November 2002

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells

scientific article

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