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List of works by Christian Doerig

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

scientific article

A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites

scientific article (publication date: 9 September 2005)

A Plasmodium falciparum homologue of the Ran binding protein 1, a protein involved in nucleocytoplasmic transport

scientific article published in August 2002

A Plasmodium falciparum transcriptional cyclin-dependent kinase-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity

scientific article (publication date: June 2010)

A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites

scientific article published in April 2008

A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei

scientific article

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase ⬇️

scientific article (publication date: 7 November 2016)

A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell

scientific article (publication date: 2007)

A parasite calcium switch and Achilles' heel revealed.

scientific article published in May 2010

A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases

scientific article (publication date: December 2013)

A stretch-activated anion channel is up-regulated by the malaria parasite Plasmodium falciparum ⬇️

scientific article published on August 2002

A study of selected Plasmodium yoelii messenger RNAs during hepatocyte infection.

scientific article published in November 2000

A transcriptional promoter of the human parvovirus B19 active in vitro and in vivo

scientific article published on 01 April 1987

ATP-site directed inhibitors of cyclin-dependent kinases.

scientific article

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

scientific article published on 4 March 2011

Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue

scientific article (publication date: 24 March 2000)

Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge

scientific article published on 31 May 2008

An RCC1-type guanidine exchange factor for the Ran G protein is found in the Plasmodium falciparum nucleus

scientific article (publication date: September 1998)

An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite

scientific article (publication date: December 2005)

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony

scientific article published on 10 November 2010

An essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites

scientific article published on 02 June 2009

An evolutionary perspective on the kinome of malaria parasites

scientific article

An overview of Plasmodium protein kinases.

scientific article

Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

scientific article published on 11 August 2020

Antimalarial drug discovery: targeting protein kinases

scientific article published on March 2007

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

scientific article

Antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a Vanuatu marine sponge Pseudoceratina sp

scientific article

CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives

scientific article

CRIMALDDI: platform technologies and novel anti-malarial drug targets

scientific article

Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome

scientific article published on 20 April 2018

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

scientific article

Cloning and characterisation of a Plasmodium falciparum homologue of the Ran/TC4 signal transducing GTPase involved in cell cycle control

scientific article published on June 1994

Cloning and characterisation of a Plasmodium falciparum homologue of the Ran/TC4 signal transducing GTPase involved in cell cycle control

scientific article published in October 1994

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

scientific article (publication date: 2013)

Cyclin-dependent kinase homologues of Plasmodium falciparum

scientific article

Disruption of the PfPK7 gene impairs schizogony and sporogony in the human malaria parasite Plasmodium falciparum

scientific article

Drugging the Plasmodium kinome: the benefits of academia-industry synergy

scientific article published on 18 April 2008

Experimental tools for the study of protein phosphorylation in Plasmodium

scientific article published in January 2013

Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes

scientific article

Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum

scientific article (publication date: March 2009)

Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics

scientific article published on 26 July 2007

Genomic analysis of the causative agents of coccidiosis in domestic chickens

scientific article

Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development.

scientific article published on 26 August 2013

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

scientific article published on 29 November 2011

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

scientific article

Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

scientific article published on 20 November 2020

Identification and initial characterization of three novel cyclin-related proteins of the human malaria parasite Plasmodium falciparum

scientific article (publication date: 10 October 2003)

In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans

scientific article

In vivo imaging enters parasitology

scientific article

Influence of Human p16INK4 and p21CIP1 on the in Vitro Activity of Recombinant Plasmodium falciparum Cyclin-Dependent Protein Kinases ⬇️

scientific article published on November 16, 2001

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission

scientific article (publication date: 2014)

Interaction of Plasmodium falciparum casein kinase 1 with components of host cell protein trafficking machinery

scientific article published on 01 May 2020

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

scientific article published in June 2000

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

scientific article (publication date: 31 January 2012)

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality

scientific article

Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1

scientific article (publication date: 2015)

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together

scientific article published on 8 September 2017

Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut.

scientific article

Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation

scientific article (publication date: 2014)

Malaria: targeting parasite and host cell kinomes

scientific article

Multispectral Atomic Force Microscopy-Infrared Nano-Imaging of Malaria Infected Red Blood Cells

scientific article published on 12 January 2018

Nima- and Aurora-related kinases of malaria parasites ⬇️

scientific article published on February 24, 2013

PAK in pathogen-host interactions

scientific article published on April 2012

Parasite protein kinases: at home and abroad

scientific article published on 01 October 2010

Pbcrk-1, the Plasmodium berghei orthologue of P. falciparum cdc-2 related kinase-1 (Pfcrk-1), is essential for completion of the intraerythrocytic asexual cycle

scientific article published on 20 December 2005

PfPK6, a novel cyclin-dependent kinase/mitogen-activated protein kinase-related protein kinase from Plasmodium falciparum

scientific article (publication date: April 2000)

PfPK7, an atypical MEK-related protein kinase, reflects the absence of classical three-component MAPK pathways in the human malaria parasite Plasmodium falciparum

scientific article (publication date: 2005)

Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum ⬇️

scientific article published on March 1, 1995

PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

scientific article (publication date: 12 May 2009)

Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.

scientific article

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

scientific article

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA

scientific article published on 10 June 2019

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes ⬇️

scientific article

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

scientific article

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

scientific article (publication date: 11 March 2004)

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase

scientific article

Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance

scientific article (publication date: 8 February 2008)

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

scientific article

Plasmodium kinases as targets for new-generation antimalarials

scientific article published on December 2012

Post-translational protein modifications in malaria parasites

scientific article published on 09 February 2015

Pre-replication complex organization in the atypical DNA replication cycle of Plasmodium falciparum: characterization of the mini-chromosome maintenance (MCM) complex formation

scientific article (publication date: 2006)

Protein kinases as drug targets in parasitic protozoa

scientific article

Protein kinases as targets for anti-parasitic chemotherapy

scientific article

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

scientific article

Protein kinases of malaria parasites: an update

scientific article published on 08 October 2008

Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote

scientific article

Regulation of Plasmodium falciparum development by calcium-dependent protein kinase 7 (PfCDPK7)

scientific article (publication date: 18 July 2014)

Regulation of protein phosphatase type 1 and cell cycle progression by PfLRR1, a novel leucine-rich repeat protein of the human malaria parasite Plasmodium falciparum

scientific article (publication date: May 2006)

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

scientific article (publication date: October 2010)

Signal transduction in malaria parasites

scientific article published in August 1997

Signalling in malaria parasites. The MALSIG consortium

scientific article published on September 2009

Signalome-wide assessment of host cell response to hepatitis C virus

scientific article published on 8 May 2017

Stopping malaria parasites dead in their tracks.

scientific article published in June 2008

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.

scientific article published on August 2001

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

scientific article

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

scientific article

Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens

scientific article

Synthesis of 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)-substituted pyrazolo[3,4-d]pyrimidin-4-amines via click chemistry: potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase

scientific article published on 2 July 2009

Targeting of host cell receptor tyrosine kinases by intracellular pathogens

scientific article published on 17 September 2019

The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes

scientific article

The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

scientific article

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation

scientific article published on 31 July 2012

The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

scientific article

The genes encoding cAMP-dependent protein kinase catalytic subunit homologues of the microsporidia Encephalitozoon intestinalis and E. cuniculi: molecular characterisation and phylogenetic analysis.

scientific article

The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

scientific article published on 17 May 2016

The kinomes of apicomplexan parasites

scientific article published on 26 April 2012

The protein-phosphatome of the human malaria parasite Plasmodium falciparum

scientific article

Toxoplasma and Plasmodium protein kinases: Roles in invasion and host cell remodelling ⬇️

scientific article published on December 4, 2011

Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor

scientific article (publication date: May 2011)

Validation of the protein kinase PfCLK3 as a multi-stage cross species malarial drug target

scholarly article published 31 August 2018

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

scientific article

[Plasmodium protein-kinases and control of cellular proliferation: molecular targets for new antimalarial drugs]

scientific article published on 01 May 2002

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