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List of works by Colin W G Fishwick

(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors ⬇️

scientific article published on 16 May 2015

1,3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin analogues

scientific article published in April 2004

2-Aminotetralones: novel inhibitors of MurA and MurZ.

scientific article published on 30 January 2008

A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

scientific article published in March 1996

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment. ⬇️

scientific article

A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis.

scientific article published on May 2012

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli

scientific article published in October 2005

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines ⬇️

scientific article

A short dipolar cycloaddition approach to γ-lactam alkaloids from cynometra hankei

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

scientific article published on 27 November 2009

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

scientific article published on 21 August 2012

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase

scientific article published on 14 February 2011

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action ⬇️

scientific article

An efficient route to S-N-(9-fluorenylmethoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl)phenylalanine

scientific article published in June 1994

An in silico structure-based approach to anti-infective drug discovery

scientific article published on 17 June 2013

Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques

scientific article published on November 2004

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques

scientific article published on 21 April 2009

Applications of structure-based design to antibacterial drug discovery

scientific article published on 02 June 2014

Assay platform for clinically relevant metallo-β-lactamases ⬇️

scientific article published on 16 August 2013

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

scientific article

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii ⬇️

scientific article published on 05 October 2018

Catalytic bimetalic [Pd(0)/Ag(I) Heck-1,3-dipolar cycloaddition cascade reactions accessing spiro-oxindoles. Concomitant in situ generation of azomethine ylides and dipolarophile ⬇️

Cis‐isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels ⬇️

scientific article published on September 1, 2010

Computational methods to identify new antibacterial targets

scientific article published on January 2015

Cyclic Boronates Inhibit All Classes of β-Lactamases ⬇️

scientific article published on 23 January 2017

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness ⬇️

scientific article

Cyclic-fused azomethine-, imidate-, and thioimidate methylides: An efficient regiocontrolled entry into spiro-fused pyrrolidines

scientific article published in July 1996

Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).

scientific article published on 19 January 2009

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

scientific article published in January 2007

Detection and mechanistic implication of a dynamic equilibrium in some novel spiro-heterocyclic systems

scientific article published in 1989

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

scientific article (publication date: August 2009)

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. ⬇️

scientific article

Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility ⬇️

scientific article

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

scientific article published on 2 October 2009

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

scientific article published on 13 December 2013

Dithiolane-isocyanate imminium methylides: A rapid stereoselective entry into γ-lactams

article published in 1995

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human ⬇️

scientific article published on 6 June 2015

Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades ⬇️

Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage

scientific article

Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease ⬇️

scientific article

Erratum: The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family ⬇️

scientific article published on 13 July 2015

Facile intramolecular cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes

scientific article published in January 1991

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones

scientific article published in August 1994

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones and the highly diastereoselective Diels-Alder reactions of 4-vinyl-1,2-isothiazoline-3-one-1-oxides

scientific article published in October 1999

Facile preparation of 2-imino tetrahydrofurans, pyrans and oxepans

scientific article published in January 1989

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases

scientific article

Formation and mechanistic implication of a novel thiaazabicyclooctane derivative drug the cycloaddition of n-acetyl cinnamic acid thioamide

scientific article published in November 1991

Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase

scientific article published on 26 July 2010

Generation and cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes. Part II. Rationalization of reactivity using an FMO approach

scientific article published in 1989

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1, 3-dienes. Structural investigations using NMR methods. Part I

scientific article published in January 1989

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes

scientific article published in January 1989

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes part III: Control of diastereoselectivity using homochiral auxiliaries

scientific article published in March 1998

Generation and cycloadditions of tetrahydrofuryl, pyranyl, and oxepanyl-2-imminium methylides

scientific article published in January 1989

Hetero-1,3-dipolar cycloadditions of dithiolane-isocyanate imminium methylides: A novel route to 1,3-oxazolidine- and thiazolidine-2-thiones

High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors ⬇️

scientific article

Highly efficient diastereoselective Exo Diels-Alder reactions of homochiral 2-(N-acylamino)-1-thia-1,3-dienes: A powerful entry into optically pure thiopyrans

scientific article published in January 1996

Hyperreactivity of adenines and conformational flexibility of a translational repression site ⬇️

scientific article published on May 20, 1991

Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation

scientific article published on January 2015

Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease ⬇️

scientific article published on 27 October 2015

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening ⬇️

scientific article published on 02 June 2018

Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ⬇️

scientific article published on 11 November 2017

Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp ⬇️

scientific article

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

scientific article published on 22 December 2017

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis ⬇️

scientific article

Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells.

scientific article published on January 2012

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. ⬇️

scientific article published on 5 December 2017

Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes ⬇️

scientific article

Intramolecular [3+2] cycloaddition versus 1,4-hydrogen shift in indolium-N-methylides

scientific article published in January 1989

Intramolecular [3+2] cycloadditions of non-stabilised azomethine imidate-methylides

scientific article published in January 1989

Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center

scientific article published on 7 January 2008

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 ⬇️

scientific article

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy

scientific article

Natural and synthetic flavonoid modulation of TRPC5 channels ⬇️

scientific article published on 13 November 2015

Neighbouring group effects in a Pummerer-type rearrangement: A facile entry into 3,1-benzoxathiins

scientific article published in June 1995

Neighbouring group participation in Pummerer-type rearrangements of ortho-substituted arylmethyl sulphoxides

scientific article published in March 1995

New Opportunities in the Structure-based Design of Anti-Protozoan Agents ⬇️

scientific article published on 19 July 2016

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections ⬇️

scientific article published on 14 July 2016

Pd(0) catalyzed three–five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid

scientific article published in July 2007

Pharmacophore model of the quercetin binding site of the SIRT6 protein

scientific article published on 20 January 2014

Photoactivatable analogues of a Substance P non-peptidic antagonist, for probing the antagonist binding site of the NK1 receptor

scientific article published in June 1995

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

scientific article published on 14 October 2011

Preparation of methyl-2-(ω-iodoalkyl)propenoates and a facile route to 2-carbomethoxy-1,3-butadiene

scientific article published in January 1989

Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists

scientific article published in November 2005

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity ⬇️

scientific article published on 7 August 2014

RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus

scientific article published on November 2000

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

scientific article published on 07 May 2015

Remarkably high diastereoselective exo diels-alder reactivity of 4-vinyl isothiazoline-3-one-1-oxides: The sulphoxide Syn effect

scientific article published in October 1995

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

scientific article published on July 2011

Selective Phosphonylation of 5'-Adenosine Monophosphate (5'-AMP) via Pyrophosphite [PPi(III)]. ⬇️

scientific article published on 24 May 2016

Spatial requirements of the antagonist binding site of the NK2 receptor.

scientific article

Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines

scientific article

Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids ⬇️

scientific article published on April 1, 2011

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ⬇️

scientific article published on 8 August 2016

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. ⬇️

scientific article published on 6 September 2017

Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

scientific article

Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase

scientific article published on 05 November 2019

Structure-based design of anti-infectives

scientific article published on December 2010

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases

scientific article

Structure-based discovery of antibacterial drugs

scientific article

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists ⬇️

scientific article

Structure-based ligand design of novel bacterial RNA polymerase inhibitors

scientific article published on 29 July 2011

Structure-switching M3L2 Ir(iii) coordination cages with photo-isomerising azo-aromatic linkers ⬇️

scientific article published on 06 September 2018

Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase

scientific article published in October 2008

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery ⬇️

scientific article published on 9 November 2017

The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen α chain.

scientific article published on 9 January 2013

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

scientific article

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

scientific article published on 19 October 2005

The first de novo-designed antagonists of the human NK(2) receptor.

scientific article published in September 2005

The first small-molecule inhibitors of members of the ribonuclease E family ⬇️

scientific article published on 26 January 2015

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

scientific article published on 3 March 2009

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design. ⬇️

scientific article published on 20 April 2017

Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality

scientific article published in December 2003

Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides

scientific article published in March 1997

Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex ⬇️

scientific article published on June 25, 1990

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. ⬇️

scientific article published on 20 February 2018

X=Y–ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer–1,3-dipolar cycloaddition (1,3-APT–1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one oxime

scientific article published in December 2003

XY–ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines

scientific article published in August 2011

[3+2] Cycloadditions of indolenine-derived azomethine ylides a rapid entry into pyrrolo [1,2-a] indolines

scientific article published in January 1988

pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases

scientific article published in August 2003

γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5-component cascades ⬇️

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