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List of works by Rachel J. Gibson

A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2

scientific journal article

A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options.

scientific article published on 31 March 2016

Animal models of mucositis: implications for therapy.

scientific article published on 24 September 2011

Beyond conventional pathology: towards preoperative and intraoperative lymph node staging.

scientific article published on 24 February 2014

Biomarkers of Small Intestinal Mucosal Damage Induced by Chemotherapy: An Emerging Role for the 13C Sucrose Breath Test ⬇️

scientific article published on June 1, 2013

Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases ⬇️

scientific article published on February 10, 2013

Biomarkers of regimen-related mucosal injury.

scientific article published on October 2011

Caffeic Acid Phenethyl Ester Abrogates Bone Resorption in a Murine Calvarial Model of Polyethylene Particle-Induced Osteolysis

scientific article published on 25 March 2015

Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies.

scientific article

Cell adhesion molecules are altered during irinotecan-induced mucositis: a qualitative histopathological study

scientific article published on 20 September 2016

Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis

scientific article published on 17 August 2007

Chemotherapy-induced diarrhoea.

scientific article published on March 2009

Chemotherapy-induced gut toxicity and pain: involvement of TLRs

scientific article published on 19 November 2015

Chemotherapy-induced gut toxicity: are alterations to intestinal tight junctions pivotal? ⬇️

scientific article published on September 30, 2012

Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.

scientific article published on January 2009

Chemotherapy-induced mucositis: the role of the gastrointestinal microbiome and toll-like receptors ⬇️

scientific article published on January 1, 2013

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction

scientific article

Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans

scientific journal article

Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer.

scientific article published on 16 September 2017

Dacomitinib-induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats

scientific article

Editorial Comment

Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats

scientific article published on 01 December 2002

Emerging evidence on the pathobiology of mucositis.

scientific article published on 11 July 2013

ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

scientific article published on 06 June 2015

Establishment of a Single-Dose Irinotecan Model of Gastrointestinal Mucositis

scientific article published on 21 August 2007

Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity.

scientific article published on 7 February 2017

Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis.

scientific article published on 28 January 2009

Gastrointestinal mucositis: the role of MMP-tight junction interactions in tissue injury

scientific article published on 15 January 2014

Gastrointestinal toxicities of first and second-generation small molecule human epidermal growth factor receptor tyrosine kinase inhibitors in advanced nonsmall cell lung cancer.

scientific article

Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy

scientific article published in October 2007

Gut microbiome and intestinal mucositis: A new challenge for researchers

scientific article published on 15 March 2009

HER2 targeted therapies for cancer and the gastrointestinal tract.

scientific article published on June 2009

Highlight article: Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity

scientific article published on 11 June 2019

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.

scientific article

Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis.

scientific article published on 12 September 2014

Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer.

scientific article published in September 2003

Irinotecan changes gene expression in the small intestine of the rat with breast cancer

scientific journal article

Irinotecan disrupts tight junction proteins within the gut : implications for chemotherapy-induced gut toxicity.

scientific article published on 06 December 2013

Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms

scientific article

Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the Dark Agouti rat.

scientific article published on 5 April 2011

Irinotecan-induced mucositis is associated with changes in intestinal mucins

scientific journal article

Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile.

scientific article published in October 2009

Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?

scientific article

Kinetics and regional specificity of irinotecan-induced gene expression in the gastrointestinal tract

scientific article published on 25 January 2010

Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics

scientific article

Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat.

scientific article published on 3 August 2010

Matrix metalloproteinases: do they play a role in mucosal pathology of the oral cavity?

scientific article published on 03 October 2012

Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?

scientific article published on 21 March 2009

Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis.

scientific article published on 3 January 2017

Mucosal injury from targeted anti-cancer therapy.

scientific article published on 14 November 2006

New pharmacotherapy options for chemotherapy-induced alimentary mucositis.

scientific article published on 06 January 2014

Noncardiac Vascular Toxicities of Vascular Endothelial Growth Factor Inhibitors in Advanced Cancer: A Review ⬇️

scientific article published on March 25, 2011

Nuclear factor κB (NFκB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes

scientific article published on 15 August 2005

Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy

scientific article published on 18 September 2006

Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats.

scientific article published in September 2005

Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report.

scientific article published on 23 December 2016

Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis

scientific article

Proteasome inhibitor-induced gastrointestinal toxicity.

scientific article published on 22 March 2017

Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2.

scientific article published on December 2006

Radiotherapy-induced gut toxicity: Involvement of matrix metalloproteinases and the intestinal microvasculature.

scientific article published on 26 February 2016

Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat

scientific article published on 01 March 2005

Routine assessment of the gut microbiome to promote preclinical research reproducibility and transparency

scientific article published on 9 January 2017

Selection of Housekeeping Genes for Gene Expression Studies in a Rat Model of Irinotecan-Induced Mucositis

article

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model

article

Severe mucositis: how can nutrition help?

scientific article published on September 2007

Sucrose breath testing and intestinal mucositis

scientific article published on 07 September 2006

Swallowing dysfunction in cancer patients.

scientific article published on 29 December 2011

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines

scientific article published on 08 July 2019

TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea.

scientific article published on 22 August 2016

TLR4/PKC-mediated tight junction modulation: a clinical marker of chemotherapy-induced gut toxicity?

scientific article

The combination of oral and small intestinal mucositis, pediatrics and biomarkers: A particularly tricky problem!

scientific article published on 07 October 2006

The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer

scientific article published on 14 May 2002

The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs.

scientific article published on 15 May 2007

The urgent need for an effective biomarker for cytotoxic therapy-induced adverse effects ⬇️

scientific article published on June 1, 2013

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer.

scientific article published on 6 October 2015

Toll-like receptor 4 signaling: a common biological mechanism of regimen-related toxicities: an emerging hypothesis for neuropathy and gastrointestinal toxicity

scientific article

Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients

scientific article published on 09 July 2008

Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats

scientific article published on 01 April 2007

What are the predictive factors in the risk and severity of chemotherapy-induced gastrointestinal toxicity?

scientific article

Why continual update of clinical practice guidelines for cytotoxic therapy-induced mucositis is essential

scientific article published on 01 September 2014

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