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List of works by Daniel G. Bracewell

A framework for the prediction of scale-up when using compressible chromatographic packings

scientific article published on 16 February 2007

A microscale approach for predicting the performance of chromatography columns used to recover therapeutic polyclonal antibodies

scientific article published on 20 September 2009

A microscale yeast cell disruption technique for integrated process development strategies.

scientific article published on 15 April 2008

A rational approach to improving titer in E. coli-based cell-free protein synthesis reactions

scientific article published on 05 August 2020

Adenovirus 5 recovery using nanofiber ion-exchange adsorbents

scientific article published on 28 March 2019

Advances in product release strategies and impact on bioprocess design.

scientific article published on July 2009

An automated microscale chromatographic purification of virus-like particles as a strategy for process development.

scientific article published in June 2007

An automated packed Protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum

scientific article published on 13 October 2010

An integrated experimental and economic evaluation of cell therapy affinity purification technologies.

scientific article published on 16 June 2017

An optical biosensor for real-time chromatography monitoring: Breakthrough determination

scientific article published on 01 October 1998

An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants

scientific article published on 18 November 2015

Assessment of the manufacturability of Escherichia coli high cell density fermentations.

scientific article

Bioprocess engineering issues that would be faced in producing a DNA vaccine at up to 100 m3 fermentation scale for an influenza pandemic.

scientific article

Bioprocess monitoring: An optical biosensor for rapid bioproduct analysis

article

Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations.

scientific article

Chemical and biological characterisation of a sensor surface for bioprocess monitoring.

scientific article published on 4 December 2010

Chromatography modelling to describe protein adsorption at bead level

scientific article published on 01 February 2013

Comparison of Techniques for Monitoring Antibody Fragment Production in E. coli Fermentation Cultures

article

Demonstration of the use of windows of operation to visualize the effects of fouling on the performance of a chromatographic step

scientific article published on 12 May 2011

Design and characterization of a microfluidic packed bed system for protein breakthrough and dynamic binding capacity determination

scientific article published in January 2009

Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

scientific article published on 14 May 2012

Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment

scientific article published on 23 August 2007

Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy

scientific article published on 28 December 2016

Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development.

scientific article published on 13 December 2017

Dual salt precipitation for the recovery of a recombinant protein from Escherichia coli.

scientific article

Dynamic Simulation of a Batch Aqueous Two-Phase Extraction Process for α-Amylase

Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells.

scientific article published on March 2017

Escherichia coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles

scientific article published in 2021

Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants.

scientific article published on 5 January 2018

Exploiting the intracellular compartmentalization characteristics of the S. cerevisiae host cell for enhancing primary purification of lipid-envelope virus-like particles

scientific article published in January 2010

Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography.

scientific article published on 12 December 2014

Factors influencing antibody stability at solid-liquid interfaces in a high shear environment

scientific article published on 01 September 2009

Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents.

scientific article published on 18 January 2018

Fluorescence based real time monitoring of fouling in process chromatography.

scientific article published on 30 March 2017

Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies ⬇️

scientific article published on March 31, 2013

Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation

scientific article published on 20 January 2020

Host cell protein adsorption characteristics during protein A chromatography.

scientific article

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line ⬇️

scientific article published on December 12, 2011

Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance

scientific article published on 28 March 2019

Impact of aeration strategy on CHO cell performance during antibody production

scientific article published on 17 November 2012

Impact of clarification strategy on chromatographic separations: Pre-processing of cell homogenates.

scientific article published in August 2008

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort

scientific article published on 23 June 2020

In situ neutron scattering of antibody adsorption during protein A chromatography

scientific article published on 09 January 2020

Integration of scale-down experimentation and general rate modelling to predict manufacturing scale chromatographic separations

scientific article published on 27 September 2010

Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

scientific article published on 20 January 2018

Manufacturing Exosomes: A Promising Therapeutic Platform

scientific article published on 12 February 2018

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

article

Mass spectrometry to describe product and contaminant adsorption properties for bioprocess development.

scientific article

Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses

scientific article published on 15 July 2014

Measurement of uptake curves and adsorption isotherms by automated microscale chromatography pipette tips

scientific article published in January 2014

Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture.

scientific article published on 18 November 2017

Nanofiber adsorbents for high productivity continuous downstream processing

scientific article published on 14 March 2015

Nanofiber adsorbents for high productivity downstream processing

scientific article published on 01 November 2012

Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface.

scientific article

Novel constructs and 1-step chromatography protocols for the production of Porcine Circovirus 2d (PCV2d) and Circovirus 3 (PCV3) subunit vaccine candidates

Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture.

scientific article

Packed bed compression visualisation and flow simulation using an erosion-dilation approach

scientific article published on 07 October 2019

Performance prediction of industrial centrifuges using scale-down models

scientific article published on 18 October 2003

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

scientific article published on 10 October 2018

Principal component score modeling for the rapid description of chromatographic separations.

scientific article published on 15 January 2008

Product and contaminant measurement in bioprocess development by SELDI-MS.

scientific article

Protein A Chromatography Resin Lifetime - Impact of Feed Composition.

scientific article published on 5 January 2018

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold.

scientific article published on 2 September 2015

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale

scientific article

Quantifying process tradeoffs in the operation of chromatographic sequences.

scientific article published in July 2003

Report and recommendation of a workshop on education and training for measurement, monitoring, modelling and control (M3C) in biochemical engineering

scientific article published on 01 April 2010

Residual on column host cell protein analysis during lifetime studies of protein A chromatography

scientific article

Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development

scientific article published on 2 September 2014

Shear effects on aluminum phosphate adjuvant particle properties in vaccine drug products

scientific article published on 29 August 2014

Soft sensors in bioprocessing: A status report and recommendations

scientific article published on 05 April 2012

Step change in the efficiency of centrifugation through cell engineering: co-expression of Staphylococcal nuclease to reduce the viscosity of the bioprocess feedstock.

scientific article published in September 2009

The challenges of product- and process-related impurities to an evolving biopharmaceutical industry.

scientific article published in January 2013

The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process ⬇️

scientific article published on August 6, 2012

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.

scientific article

Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy

scientific article published on 25 June 2018

Ultra scale-down approach to correct dispersive and retentive effects in small-scale columns when predicting larger scale elution profiles

scientific article published on 01 July 2009

Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production

scientific article published on 8 January 2018

Ultra scale-down to define and improve the relationship between flocculation and disc-stack centrifugation

scientific article published on 7 March 2008

Understanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4

scientific article

X-ray computed tomography of packed bed chromatography columns for three dimensional imaging and analysis

scientific article

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