List of works - Peter C Tyler

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

scientific article

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol

scientific article published on 20 July 2007

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

scientific article published on 3 July 2003

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

scientific article published on 11 May 2007

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

scientific article published on 5 March 2013

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

scientific article published on June 2009

Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs.

scientific article

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

scientific article

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

scientific article published on 6 February 2008

Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents

scientific article published on 12 June 2020

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

scientific article

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy

scientific article published on 29 November 2018

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

scientific article published on 16 June 2005

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

scientific article published on 7 November 2011

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

scientific article

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

scientific article

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

scientific article published on 04 March 2005

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

scientific article

Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone

scientific article published in March 2004

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

scientific article (publication date: December 2015)

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

scientific article

Immucillins in Infectious Diseases

scientific article

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

scientific article

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

scientific article published on 01 November 2021

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

scientific article

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

scientific article

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

scientific article published in May 2003

Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.

scientific article published on 5 July 2017

New Antibiotic Candidates against Helicobacter pylori

scientific article

Oligonucleotide transition state analogues of saporin L3.

scientific article

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

scientific article (publication date: 27 May 2003)

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

scientific article

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

scientific article published on 23 February 2004

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

scientific article published on 12 November 2001

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

scientific article published on July 2005

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

scientific article published on 28 March 2019

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

scientific article published on 20 March 2020

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

scientific article published on October 2006

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

scientific article published on 26 January 2006

Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1

scientific article published on 24 March 2022

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes

scientific article

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

scientific article published on 01 October 2003

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

scientific article published in November 2003

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

scientific article (publication date: 11 March 2005)

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

scientific article

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

scientific article published on 20 August 2015

The transition to magic bullets – transition state analogue drug design

scientific article published on 28 August 2018

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase

scientific article published on 8 November 2013

Tight binding enantiomers of pre-clinical drug candidates

scientific article

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

scientific article published on 24 August 2017

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

scientific article published on 11 February 2020

Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.

scientific article published on 5 September 2017

Transition state analogue discrimination by related purine nucleoside phosphorylases

scientific article

Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum

scientific article published on 13 November 2001

Transition state analogues in quorum sensing and SAM recycling

scientific article published on January 2008

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases

scientific article published on 24 October 2013

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein

scientific article published in October 2009

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase

scientific article published on 19 October 2018

Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

scientific article published in 2019

List of works by Peter C Tyler

8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol

Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase

Acyclic Ribooxacarbenium Ion Mimics as Transition State Analogues of Human and Malarial Purine Nucleoside Phosphorylases

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase

Assignment of downfield proton resonances in purine nucleoside phosphorylase immucillin-H complex by saturation-transferred NOEs.

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases

Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents

Conformational states of human purine nucleoside phosphorylase at rest, at work, and with transition state analogues

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy

Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases.

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase.

Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

Immucillins in Infectious Diseases

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state.

Inhibitors of ADP-ribosylating bacterial toxins based on oxacarbenium ion character at their transition states

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.

New Antibiotic Candidates against Helicobacter pylori

Oligonucleotide transition state analogues of saporin L3.

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes

Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction

Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase

The Immucillins: Design, Synthesis and Application of Transition- State Analogues.

The transition to magic bullets – transition state analogue drug design

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase

Tight binding enantiomers of pre-clinical drug candidates

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase.

Transition state analogue discrimination by related purine nucleoside phosphorylases

Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum

Transition state analogues in quorum sensing and SAM recycling

Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein

Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase

Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors