List of works - Carmela R Abraham

?1-Antichymotrypsin Binding to Alzheimer A? Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

scientific article published on 01 July 1993

A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein.

scientific article published in January 1991

A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein

scientific article published in September 1992

A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone

scientific article published on 29 April 2020

A novel brain cysteine protease forms an SDS stable complex with the beta-amyloid precursor protein

scientific article published in January 1996

Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey

scientific article

Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain

scientific article published on 29 June 2005

Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex

scientific article published on 19 January 2018

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide.

scientific article published on 23 July 2009

Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide

scientific article

Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts

scientific article

Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey

scientific article published in January 2003

Age-related molecular reorganization at the node of Ranvier

scientific article published on April 2006

Allele ε4 of Apolipoprotein E Shows a Dose Effect on Age at Onset of Pick Disease

scientific article published on 01 December 1995

Alpha 1-antichymotrypsin in brain aging and disease.

scientific article

Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo.

scientific article published in January 2000

Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin

scientific article published in March 1990

Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies

scientific article published in September 1984

Amyloid beta peptide: a century of discoveries.

scientific article

Amyloid precursor protein interacts with notch receptors

scientific journal article

Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized.

scientific article published in August 1993

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

scientific article published on May 1997

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

scientific article published in August 1983

Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells

scientific article

Association between bleomycin hydrolase and Alzheimer's disease in caucasians

scientific article published in November 1998

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

scientific article published on November 1989

Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey

scientific article published on 01 April 2000

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

scientific article published in December 2000

Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

scientific article

Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases

scientific article published in September 1998

Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys.

scientific article published on 22 January 2018

Cell-type dependent modulation of Notch signaling by the amyloid precursor protein

scientific article

Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

scientific article published on January 1994

Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.

scientific article published on 8 March 2013

Demonstration of plasma proteinase inhibitors in beta 2-microglobulin amyloid deposits

scientific article published on October 1, 1992

Detection of Amyloid-β Protein Precursor Homo-Interactions Using Beta-Galactosidase Enzyme Fragment Complementation ⬇️

scientific article published on 01 January 2011

Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis.

scientific article published in September 1991

Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain.

scientific article

Expression of cathepsin G-like and α1-antichymotrypsin-like proteins in reactive astrocytes

scientific article published on 01 September 1993

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

scientific article published in January 2008

Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus

scientific article

Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

scientific article

Identification of a novel serine protease-like molecule in human brain

scientific article

Identification of cleavage sites leading to the shed form of the anti-aging protein klotho

scientific article published on 20 August 2014

Identification of novel small molecules that elevate Klotho expression

scientific article published on January 2012

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

scientific article published on 13 January 2020

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

scientific article

Increased microglial activation and protein nitration in white matter of the aging monkey☆

scientific article published on 01 July 1999

Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains.

scientific article published on September 1998

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

scholarly article

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

scientific article published on August 1997

Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease

scientific article published in June 1986

Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS

scientific article published on 27 June 2019

Klotho Is a Neuroprotective and Cognition-Enhancing Protein

scientific article

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress

scientific article published on 23 December 2019

Klotho, PTSD, and advanced epigenetic age in cortical tissue

scientific article published on 23 October 2020

Lack of correlation between plaque burden and cognition in the aged monkey

scientific article published in November 1997

Life extension factor klotho enhances cognition

scientific article

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

scientific article

Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization

scientific article

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

scientific article

MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro

scientific article published on 02 July 2013

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

scientific article published on December 1984

Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain.

scientific article published in May 1996

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

scientific article published on November 1993

Neurotrophic and neuroprotective effects of hAPP in transgenic mice

scientific article published on January 1996

Neutrophil Proteases Associated with Amyloid Fibrils

scientific article published on 01 November 1993

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.

scientific article published on 18 March 2008

PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation

scientific article published on 29 July 2014

PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation

scientific article published on 13 April 2020

Platelets and DAMI megakaryocytes possess beta-secretase-like activity

scientific article published in May 1999

Potential roles of protease inhibitors in Alzheimer's disease

scientific article published on 01 September 1989

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

scientific article

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

scientific article

Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein

scientific article published on December 31, 1992

Purification and cloning of monkey proteases involved in the processing of the β-amyloid precursor protein

scientific article published on 01 November 1993

Radioimmunoassay of the APC Gene Product Using Antibodies against Its Middle and Carboxyl Regions

article

Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease.

scientific article

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease

scientific article

Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling

scientific article published on 01 January 2019

Small-molecule Klotho enhancers as novel treatment of neurodegeneration

scientific article

Studies on the Proteolytic Degradation of theβ-Protein Precursor by Proteases Purified from Alzheimer's Disease Braina ⬇️

scientific article published on January 1, 1991

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

scientific article published on 01 December 1994

Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes

scientific article published in September 1996

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans

scientific article published on 7 March 2018

The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination

scientific article published on 12 June 2015

The Fibril Forming Region of the β-Amyloid Precursor Differs from That of the Amyloid A Precursor in Its Interaction with Lipids1

scientific article published on 01 February 1996

The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line

scientific article (publication date: 2015)

The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.

scientific article published on January 2013

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation

scientific article (publication date: March 2003)

The neuroprotective effect of Klotho is mediated via regulation of members of the redox system

scientific article

The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease

scientific article published in January 1989

The role of the acute-phase protein alpha 1-antichymotrypsin in brain dysfunction and injury

scientific article published on July 1, 1992

Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation

scientific article published on 3 March 2006

What's behind the decline? The role of white matter in brain aging.

scientific article published on 20 April 2007

miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy

scientific article published on 01 March 2021

α1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits

scientific article published on 01 January 1989

List of works by Carmela R Abraham

?1-Antichymotrypsin Binding to Alzheimer A? Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein.

A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein

A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone

A novel brain cysteine protease forms an SDS stable complex with the beta-amyloid precursor protein

Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey

Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain

Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide.

Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide

Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts

Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey

Age-related molecular reorganization at the node of Ranvier

Allele ε4 of Apolipoprotein E Shows a Dose Effect on Age at Onset of Pick Disease

Alpha 1-antichymotrypsin in brain aging and disease.

Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo.

Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin

Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies

Amyloid beta peptide: a century of discoveries.

Amyloid precursor protein interacts with notch receptors

Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized.

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells

Association between bleomycin hydrolase and Alzheimer's disease in caucasians

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases

Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys.

Cell-type dependent modulation of Notch signaling by the amyloid precursor protein

Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.

Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.

Demonstration of plasma proteinase inhibitors in beta 2-microglobulin amyloid deposits

Detection of Amyloid-β Protein Precursor Homo-Interactions Using Beta-Galactosidase Enzyme Fragment Complementation ⬇️

Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis.

Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain.

Expression of cathepsin G-like and α1-antichymotrypsin-like proteins in reactive astrocytes

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus

Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

Identification of a novel serine protease-like molecule in human brain

Identification of cleavage sites leading to the shed form of the anti-aging protein klotho

Identification of novel small molecules that elevate Klotho expression

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

Increased microglial activation and protein nitration in white matter of the aging monkey☆

Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains.

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease

Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS

Klotho Is a Neuroprotective and Cognition-Enhancing Protein

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress

Klotho, PTSD, and advanced epigenetic age in cortical tissue

Lack of correlation between plaque burden and cognition in the aged monkey

Life extension factor klotho enhances cognition

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain.

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

Neurotrophic and neuroprotective effects of hAPP in transgenic mice

Neutrophil Proteases Associated with Amyloid Fibrils

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.

PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation

PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation

Platelets and DAMI megakaryocytes possess beta-secretase-like activity

Potential roles of protease inhibitors in Alzheimer's disease

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein

Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein

Purification and cloning of monkey proteases involved in the processing of the β-amyloid precursor protein

Radioimmunoassay of the APC Gene Product Using Antibodies against Its Middle and Carboxyl Regions

Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease.

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease