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List of works by Jinwei Zhang

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

scientific article

Brain Penetrant LRRK2 Inhibitor

scientific article

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

scientific article

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

scientific article published on 20 May 2015

Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K+-Cl- Cotransporter KCC2.

scientific article published on 21 May 2019

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

scientific article published on 16 December 2012

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival

scientific article published on 15 October 2019

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

scientific article published on 7 April 2015

Enhanced eicosapentaenoic acid production by a new deep-sea marine bacterium Shewanella electrodiphila MAR441T.

scientific article

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase

scientific article published on 24 November 2017

GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

scientific article

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology

scientific article published on 15 October 2019

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

scientific article published on 10 July 2017

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

scientific article

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

scientific article

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.

scientific article published on 18 October 2016

MALDI-TOF Mass Spectrometry Discriminates Known Species and Marine Environmental Isolates of Pseudoalteromonas

scientific article

Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a

scientific article published on 07 January 2020

Molecular cloning and expression of a cold-adapted lipase gene from an Antarctic deep sea psychrotrophic bacterium Pseudomonas sp. 7323.

scientific article published on 7 May 2008

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation

scientific article published on 18 December 2018

New drugs on the horizon for cerebral edema: what's in the clinical development pipeline?

scientific article published on 20 August 2020

Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter

scientific article published on 2 August 2016

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.

scientific article published on 6 July 2017

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

scientific article published on 14 October 2020

Shewanella dovemarinesis sp. nov., a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments

scientific article

Shewanella electrodiphila sp. nov., a psychrotolerant bacterium isolated from Mid-Atlantic Ridge deep-sea sediments.

scientific article

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1

scientific article published on 15 May 2020

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

scientific article published on 31 August 2018

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

scientific article published on 29 October 2013

The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington's Disease and Its Comorbidities

scientific article published on 30 November 2020

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

scientific article published on 15 July 2014

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

scientific article

The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

scientific article published on 14 August 2018

WNK Kinase Signaling in Ion Homeostasis and Human Disease.

scientific article published on February 2017

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