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List of works by Harald Neumann

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region

scientific article published on 14 December 2020

A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells

scientific article

Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia.

scientific article published on 19 April 2015

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator

scientific article

Alleviation of neurotoxicity by microglial human Siglec-11.

scientific article published in March 2010

Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages

scientific article

Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke

scientific article

Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro.

scientific article published on 24 August 2007

Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide.

scientific article published in January 2005

Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene

scientific article published on 24 April 2007

CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons

scientific article published on 12 September 2018

CXCL10 triggers early microglial activation in the cuprizone model

scientific article published on 27 February 2015

Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia.

scientific article published on 09 March 2016

Charged aerosol detector HPLC as a characterization and quantification application of biopharmaceutically relevant polysialic acid from E. coli K1

scientific article published on 01 April 2019

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

scientific article published on February 2005

Control of Innate Immunity by Sialic Acids in the Nervous Tissue

scientific article published on 31 July 2020

Debris clearance by microglia: an essential link between degeneration and regeneration.

scientific article published on 20 June 2008

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

scientific article

Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis

scientific article published on 17 January 2013

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

scientific article

Generation of microglial cells from mouse embryonic stem cells

scientific article

Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury

scientific article published on 24 July 2008

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

scientific article published on 01 August 2018

Immune-mediated CNS damage

scientific article

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

scientific article published on April 2013

Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia

scientific article published on 3 April 2017

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis.

scientific article published on 30 January 2013

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

scientific article published on 27 April 2005

Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ.

scientific article published on 24 March 2012

Microglia: a cellular vehicle for CNS gene therapy.

scientific article

Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst

scientific journal article

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx.

scientific article published on 21 May 2012

Microglial carbohydrate-binding receptors for neural repair.

scientific article published on 14 February 2012

Microglial clearance function in health and disease

scientific article published on July 2008

Microglial precursors derived from mouse embryonic stem cells.

scientific article

Neurodegeneration by activation of the microglial complement-phagosome pathway.

scientific article

Neuronal 'On' and 'Off' signals control microglia

scientific article published on 24 October 2007

Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).

scientific article published on 19 December 2003

Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides

scientific article published on 28 July 2020

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

scientific article

Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages

scientific article published on 9 May 2016

Protective effects of microglia in multiple sclerosis.

scientific article published on 04 May 2009

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

scientific article published on 29 June 2021

Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins.

scientific article

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

scientific article published on 27 September 2013

Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia

scientific article

Sialylation acts as a checkpoint for innate immune responses in the central nervous system

scientific article published on 19 December 2020

Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron Co-Culture System

scientific article published on 10 August 2015

Siglec functions of microglia

scientific article published on 15 May 2014

Siglec-h on activated microglia for recognition and engulfment of glioma cells

scientific article published on 30 April 2013

Single-use membrane adsorbers for endotoxin removal and purification of endogenous polysialic acid from Escherichia coli K1.

scientific article published on 8 February 2018

Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer.

scientific article

Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.

scientific article published on December 2006

TREM2 triggers microglial density and age-related neuronal loss

scientific article published on 11 December 2018

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis

scientific article

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma

scientific article published on June 2013

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

scientific article published on 08 January 2014

Unique transcriptome signature of mouse microglia

scientific article

Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway.

scientific article published on 26 October 2006

Variant TREM2 as Risk Factor for Alzheimer's Disease ⬇️

scientific article published on November 14, 2012

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