List of works - Michael J May

A critical role for SOCS3 in innate resistance to Toxoplasma gondii

scientific article

A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage

scientific article

A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase

scientific article

A nuclear factor in B cells and beyond

scientific article published on December 2006

A phase I clinical trial of systemically delivered NEMO binding domain peptide in dogs with spontaneous activated B-cell like diffuse large B-cell lymphoma

scientific article (publication date: 2014)

Activation of p42mapk in human umbilical vein endothelial cells by interleukin-1α and tumor necrosis factor-α ⬇️

scientific article published on March 1, 1998

Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species

scientific article

Characterization of the Ikappa B-kinase NEMO binding domain

scientific article published on 19 September 2002

Classical NF-kappaB activation negatively regulates noncanonical NF-kappaB-dependent CXCL12 expression

scientific article

Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells

scientific article

Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.

scientific article

Cytokine-induced E-selectin expression by human umbilical vein endothelial cells (HUVEC). A role for protein tyrosine kinases?

scientific article published on 01 May 1995

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

scientific article

Effects of protein tyrosine kinase inhibitors on cytokine-induced adhesion molecule expression by human umbilical vein endothelial cells

scientific article published in August 1996

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

scientific article published in Nature

Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.

scientific article

G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence

scientific article published on 27 August 2007

Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity

scientific article published on 11 October 2008

ICAM-1-independent lymphocyte transmigration across high endothelium : Differential up-regulation by interferon γ, tumor necrosis factor-α and interleukin 1β

scientific article published on 01 January 1992

IL-17R signaling: new players get in on the Act1 ⬇️

scientific article published on August 18, 2011

Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei

scientific article published on 01 August 2005

Inhibiting proinflammatory NF-kappaB signaling using cell-penetrating NEMO binding domain peptides

scientific article published in January 2009

Inhibition of MAP kinase kinase (MEK) blocks endothelial PGI2 release but has no effect on von Willebrand factor secretion or E-selectin expression

scientific article published on 01 June 1996

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

scientific article published in January 2005

Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies

scientific article published on February 2002

Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis

scientific article

Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii.

scientific article

Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta

scientific article

Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor

scientific article published on June 2006

Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation

scientific article published on January 2006

Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells

scientific article published on March 2008

NEMO-Binding Domain Peptide Inhibition of Inflammatory Signal-Induced NF-κB Activation In Vivo

scientific article published on 01 January 2015

NEMO-binding domain peptide inhibits constitutive NF-κB activity and reduces tumor burden in a canine model of relapsed, refractory diffuse large B-cell lymphoma

scientific article published on 24 May 2011

NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation

scientific article published on 07 August 2009

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

scientific article (publication date: April 1998)

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases

scientific article published on 23 September 2013

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

scientific article

NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain.

scientific article

NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells

scientific article published on December 2007

Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis

scientific article published on 2 June 2014

Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.

scientific article

Noncanonical NF-κB activation and SDF-1 expression in human endothelial cells

scientific article published on January 2015

Noncanonical NF-κB signaling is limited by classical NF-κB activity

scientific article published on 04 February 2014

Preface. NF-kappa B

scientific article published on 01 January 2015

Raising the price of platinum: inhibition of NFkappaB in human tumor epithelial cells

scientific article published on September 2008

RelB forms transcriptionally inactive complexes with RelA/p65.

scientific article published on 25 March 2003

Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis

scientific article

SIGNAL TRANSDUCTION:IkB Kinases: Kinsmen with Different Crafts

scientific article

Selective inhibition of NF-?B in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization

scientific article published on 01 April 2005

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

scientific article

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

scientific article

Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death

scientific article published on August 2002

Signal transduction through NF-kappa B.

scientific article published on February 1998

Sneaking-Ligand Fusion Proteins Attenuate Serum Transfer Arthritis by Endothelium-Targeted NF-κB Inhibition

scientific article published on 01 January 2015

Stable reconstitution of IKK-deficient mouse embryonic fibroblasts

scientific article

Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines

scientific article

T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry

scientific article published on 29 January 2016

The IkappaB kinase complex: master regulator of NF-kappaB signaling

scientific article

The NFκB paradox: RelB induces and inhibits gene expression

article

The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK

scientific journal article

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

scientific article

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

scientific article published on 30 January 2014

Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells

scientific article published on 10 July 2003

Understanding high endothelial venules: Lessons for cancer immunology

scientific article

List of works by Michael J May

A critical role for SOCS3 in innate resistance to Toxoplasma gondii

A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage

A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase

A nuclear factor in B cells and beyond

A phase I clinical trial of systemically delivered NEMO binding domain peptide in dogs with spontaneous activated B-cell like diffuse large B-cell lymphoma

Activation of p42mapk in human umbilical vein endothelial cells by interleukin-1α and tumor necrosis factor-α ⬇️

Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species

Characterization of the Ikappa B-kinase NEMO binding domain

Classical NF-kappaB activation negatively regulates noncanonical NF-kappaB-dependent CXCL12 expression

Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells

Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.

Cytokine-induced E-selectin expression by human umbilical vein endothelial cells (HUVEC). A role for protein tyrosine kinases?

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Effects of protein tyrosine kinase inhibitors on cytokine-induced adhesion molecule expression by human umbilical vein endothelial cells

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.

G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence

Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity

ICAM-1-independent lymphocyte transmigration across high endothelium : Differential up-regulation by interferon γ, tumor necrosis factor-α and interleukin 1β

IL-17R signaling: new players get in on the Act1 ⬇️

Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei

Inhibiting proinflammatory NF-kappaB signaling using cell-penetrating NEMO binding domain peptides

Inhibition of MAP kinase kinase (MEK) blocks endothelial PGI2 release but has no effect on von Willebrand factor secretion or E-selectin expression

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies

Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis

Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii.

Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta

Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor

Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation

Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells

NEMO-Binding Domain Peptide Inhibition of Inflammatory Signal-Induced NF-κB Activation In Vivo

NEMO-binding domain peptide inhibits constitutive NF-κB activity and reduces tumor burden in a canine model of relapsed, refractory diffuse large B-cell lymphoma

NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain.

NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells

Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis

Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.

Noncanonical NF-κB activation and SDF-1 expression in human endothelial cells

Noncanonical NF-κB signaling is limited by classical NF-κB activity

Preface. NF-kappa B

Raising the price of platinum: inhibition of NFkappaB in human tumor epithelial cells

RelB forms transcriptionally inactive complexes with RelA/p65.

Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis

SIGNAL TRANSDUCTION:IkB Kinases: Kinsmen with Different Crafts

Selective inhibition of NF-?B in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

Selective targeting of the nuclear factor-kappaB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death

Signal transduction through NF-kappa B.

Sneaking-Ligand Fusion Proteins Attenuate Serum Transfer Arthritis by Endothelium-Targeted NF-κB Inhibition

Stable reconstitution of IKK-deficient mouse embryonic fibroblasts

Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines

T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry

The IkappaB kinase complex: master regulator of NF-kappaB signaling

The NFκB paradox: RelB induces and inhibits gene expression

The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells

Understanding high endothelial venules: Lessons for cancer immunology