List of works - Peter Friedl

3D spheroid culture to examine adaptive therapy response in invading tumor cells

scientific article published in 2023

A Swiss Army knife for CTLs.

scientific article published on December 2014

A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling.

scientific article published on October 2010

A large-scale 19F MRI-based cell migration assay to optimize cell therapy

scientific article published on 07 February 2012

A three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes.

scientific article published on 16 September 2010

Adaptive adhesion systems mediate glioma cell invasion in complex environments

scientific article published on 13 August 2018

An open data ecosystem for cell migration research

scientific article

Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?

scientific article published on 12 March 2016

Biological second and third harmonic generation microscopy

scientific article

Cancer cells: Stemness shaped by curvature

scientific article published on 01 July 2016

Cancer invasion and resistance

scientific article

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure ⬇️

scientific article published on December 15, 2011

Cancer invasion and the microenvironment: plasticity and reciprocity

scientific article

Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement.

scientific article published on 8 April 2014

Cell-cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

scientific article published on 24 August 2020

Classifying collective cancer cell invasion

scientific article published on August 2012

Collective cell migration in morphogenesis, regeneration and cancer

scientific article (publication date: July 2009)

Collective cell migration: guidance principles and hierarchies

scientific article published on 29 June 2015

Collective invasion in ductal and lobular breast cancer associates with distant metastasis.

scientific article published on 11 September 2017

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

scientific journal article

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

scientific article (publication date: 20 January 2003)

Confocal reflection imaging of 3D fibrin polymers.

scientific article published on 17 February 2006

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

scientific article published on 01 September 2021

Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment.

scientific article published on 17 February 2011

Determinants of leader cells in collective cell migration ⬇️

scientific article published on October 1, 2010

Directing collagen fibers using counter-rotating cone extrusion

scientific article published on 16 October 2014

Diversity in immune-cell interactions: states and functions of the immunological synapse.

scientific article published in October 2004

Dorsoventral polarity directs cell responses to migration track geometries

scientific article published on 31 July 2020

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model.

scientific article

Dynamic imaging of cancer invasion and metastasis: principles and preclinical applications.

scientific article published on January 2009

Dynamic imaging of cellular interactions with extracellular matrix

scientific article published on 16 July 2004

Dynamic imaging of the immune system

scientific article published on 01 August 2004

Dynamics of cell-cell and cell-matrix interactions in morphogenesis, regeneration and cancer

scientific article published on 16 September 2010

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy

scientific article published on 19 December 2016

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration.

scientific article published on 27 October 2011

Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells

scientific article published on 13 February 2017

Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity.

scientific article published on January 2012

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.

scientific article published on June 2015

Functional imaging of pericellular proteolysis in cancer cell invasion.

scientific article

Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization

scientific article

Hypoxia Induces a HIF-1-Dependent Transition from Collective-to-Amoeboid Dissemination in Epithelial Cancer Cells.

scientific article published on 11 January 2017

IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells

scientific article published on 03 November 2020

Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery

scientific article

Interstitial guidance of cancer invasion

scientific article

Intravital microscopy of collective invasion plasticity in breast cancer

scientific article published on 23 August 2018

Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone

scientific article published in August 2018

MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.

scientific article

Mechanoreciprocity in cell migration.

scientific article published on 21 December 2017

Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: filopod-mediated extension-relaxation cycles and force anisotropy

scientific article published on 2 July 2013

New dimensions in cell migration

Nuclear envelope rupture and repair during cancer cell migration.

scientific article published on 24 March 2016

Nuclear mechanics during cell migration.

scientific article

Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force

scientific article

Plasticity of Cancer Cell Invasion-Mechanisms and Implications for Therapy.

scientific article published on 17 August 2016

Plasticity of Cell Migration In Vivo and In Silico.

scientific article

Plasticity of cancer invasion and energy metabolism

scientific article published in 2023

Plasticity of the actin cytoskeleton in response to extracellular matrix nanostructure and dimensionality

scientific article published on 01 October 2014

Plasticity of tumor cell invasion: governance by growth factors and cytokines.

scientific article published on 23 September 2016

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response.

scientific article published on 26 July 2013

Proteolytic interstitial cell migration: a five-step process.

scientific article published on June 2009

Rational Design of Mouse Models for Cancer Research.

scientific article published on 5 January 2018

Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells.

scientific article

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

scientific article published on 19 August 2017

Rethinking research into metastasis

scientific article published on 17 December 2019

Rho GTPases in collective cell migration

scientific article

Rho-directed forces in collective migration

scientific article published on 01 March 2014

Single cell-based automated quantification of therapy responses of invasive cancer spheroids in organotypic 3D culture.

scientific article

Stathmin activity influences sarcoma cell shape, motility, and metastatic potential.

scientific article published on 27 February 2008

Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation

scientific article published on 29 April 2016

T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensations

scientific article

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.

scientific article

The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.

scientific article

Third harmonic generation microscopy of cells and tissue organization

scientific article

To adhere or not to adhere?

scientific article published on 01 January 2010

Translating Membrane Tension into Cytoskeletal Action by FBP17

scientific article published on 01 June 2015

Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier

scientific article published on 01 July 2008

Tube travel: the role of proteases in individual and collective cancer cell invasion

scientific article published on September 2008

Tumour-cell invasion and migration: diversity and escape mechanisms

scientific article (publication date: May 2003)

Tuning Collective Cell Migration by Cell-Cell Junction Regulation.

scientific article published on 17 January 2017

Tuning immune responses: diversity and adaptation of the immunological synapse.

scientific article

Twenty-third annual Pezcoller Symposium: engineering influences in cancer research

scientific article published on 11 January 2012

Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion

scientific article

p120-catenin-dependent collective brain infiltration by glioma cell networks

scientific article published on 06 January 2020

p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling

scientific article

p53 family members in myogenic differentiation and rhabdomyosarcoma development

scientific article

List of works by Peter Friedl

3D spheroid culture to examine adaptive therapy response in invading tumor cells

A Swiss Army knife for CTLs.

A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling.

A large-scale 19F MRI-based cell migration assay to optimize cell therapy

A three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes.

Adaptive adhesion systems mediate glioma cell invasion in complex environments

An open data ecosystem for cell migration research

Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?

Biological second and third harmonic generation microscopy

Cancer cells: Stemness shaped by curvature

Cancer invasion and resistance

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure ⬇️

Cancer invasion and the microenvironment: plasticity and reciprocity

Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement.

Cell-cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Classifying collective cancer cell invasion

Collective cell migration in morphogenesis, regeneration and cancer

Collective cell migration: guidance principles and hierarchies

Collective invasion in ductal and lobular breast cancer associates with distant metastasis.

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

Confocal reflection imaging of 3D fibrin polymers.

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment.

Determinants of leader cells in collective cell migration ⬇️

Directing collagen fibers using counter-rotating cone extrusion

Diversity in immune-cell interactions: states and functions of the immunological synapse.

Dorsoventral polarity directs cell responses to migration track geometries

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model.

Dynamic imaging of cancer invasion and metastasis: principles and preclinical applications.

Dynamic imaging of cellular interactions with extracellular matrix

Dynamic imaging of the immune system

Dynamics of cell-cell and cell-matrix interactions in morphogenesis, regeneration and cancer

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration.

Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells

Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity.

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.

Functional imaging of pericellular proteolysis in cancer cell invasion.

Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization

Hypoxia Induces a HIF-1-Dependent Transition from Collective-to-Amoeboid Dissemination in Epithelial Cancer Cells.

IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells

Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery

Interstitial guidance of cancer invasion

Intravital microscopy of collective invasion plasticity in breast cancer

Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone

MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.

Mechanoreciprocity in cell migration.

Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: filopod-mediated extension-relaxation cycles and force anisotropy

New dimensions in cell migration

Nuclear envelope rupture and repair during cancer cell migration.

Nuclear mechanics during cell migration.

Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force

Plasticity of Cancer Cell Invasion-Mechanisms and Implications for Therapy.

Plasticity of Cell Migration In Vivo and In Silico.

Plasticity of cancer invasion and energy metabolism

Plasticity of the actin cytoskeleton in response to extracellular matrix nanostructure and dimensionality

Plasticity of tumor cell invasion: governance by growth factors and cytokines.

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response.

Proteolytic interstitial cell migration: a five-step process.

Rational Design of Mouse Models for Cancer Research.

Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells.

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

Rethinking research into metastasis

Rho GTPases in collective cell migration

Rho-directed forces in collective migration

Single cell-based automated quantification of therapy responses of invasive cancer spheroids in organotypic 3D culture.

Stathmin activity influences sarcoma cell shape, motility, and metastatic potential.

Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation

T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensations

The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism.

The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.

Third harmonic generation microscopy of cells and tissue organization

To adhere or not to adhere?

Translating Membrane Tension into Cytoskeletal Action by FBP17

Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier

Tube travel: the role of proteases in individual and collective cancer cell invasion

Tumour-cell invasion and migration: diversity and escape mechanisms

Tuning Collective Cell Migration by Cell-Cell Junction Regulation.