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List of works by Walter W Chen

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

scientific article

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

scientific article

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

scientific article published on August 2016

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

scientific article published in July 2015

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles.

scientific article published on 23 July 2013

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition

scientific article

Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model

scientific article published on May 2011

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

scientific article

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

scientific article published on February 2017

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

scientific article

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

scientific article

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

scientific article published on 12 December 2018

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

scientific article

RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors.

scientific article

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

scientific article published on 29 September 2017

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

scientific article

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.

scholarly article

Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

scientific article

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

scientific article

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