List of works by Gonzalo Gómez-López

A Braf kinase-inactive mutant induces lung adenocarcinoma.

scientific article published on 2 August 2017

A comprehensive database for integrated analysis of omics data in autoimmune diseases

scientific article published on 24 June 2021

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

scientific article published on September 2016

A unique role of cohesin-SA1 in gene regulation and development

scientific journal article

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

scientific article published on January 2013

ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia.

scientific article published on 8 November 2013

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

scientific article published on 31 January 2022

Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance

scientific article

Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma.

scientific article

Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer

scientific article published on 13 May 2020

Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data

scientific article published on 16 December 2021

CARGO: a web portal to integrate customized biological information

scientific article published on 5 May 2007

CSF3R T618I co-occurs with mutations of splicing and epigenetic genes and with a new PIM3 truncated fusion gene in chronic neutrophilic leukemia

scientific article

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

scientific article published on 12 December 2011

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs.

scientific article published on 13 January 2012

Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway

scientific article

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

scientific article published on 8 February 2016

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

scientific article

DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers

scientific article published on 14 June 2015

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

scientific article published on 04 June 2018

Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype.

scientific article published on 22 October 2012

Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.

scientific article published on May 2011

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm

scientific article published on 27 September 2013

Expression and functional validation of new p38α transcriptional targets in tumorigenesis

scientific article published on 01 March 2011

Functional characterization of E- and P-cadherin in invasive breast cancer cells

scientific article

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

scientific article

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions

scientific article

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells

scientific article published on 10 April 2017

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

scientific article published on 28 September 2020

In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome

scientific article published on 13 September 2019

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer

scientific article published in Nature Communications

Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway.

scientific article

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

scientific article

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

scientific article

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia

scientific article published on 09 December 2019

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

scientific journal article

Mantle cell lymphoma: transcriptional regulation by microRNAs

scientific article published on 20 May 2010

Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5.

scientific article published on 27 July 2016

MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors

scientific article published on 19 June 2014

MicroRNA signatures in B-cell lymphomas.

scientific article published on 17 February 2012

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

scientific article published on 3 April 2015

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

scientific article published on 19 October 2020

Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

scientific article

New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing ⬇️

scientific article

PLCG1 mutations in cutaneous T-cell lymphomas

scientific article published on 4 February 2014

PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.

scientific article

Pancreas Cancer Precision Treatment Using Avatar Mice from a Bioinformatics Perspective

scientific article published in September 2017

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis

scientific article published on 14 October 2015

PathJam: a new service for integrating biological pathway information

scientific article published on 28 October 2010

PileLine: a toolbox to handle genome position information in next-generation sequencing studies

scientific article

PileLineGUI: a desktop environment for handling genome position files in next-generation sequencing studies

scientific article

Precision medicine needs pioneering clinical bioinformaticians.

scientific article published on 25 October 2017

Prediction of miRNA-mRNA Interactions Using miRGate

scientific article published on January 2017

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation

scientific article

Programmed cell senescence during mammalian embryonic development

scientific article published on 14 November 2013

Pten positively regulates brown adipose function, energy expenditure, and longevity

scientific article

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway

scientific article

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

scientific article published on 17 May 2021

RAP1 protects from obesity through its extratelomeric role regulating gene expression

scientific article published on 20 June 2013

RUbioSeq+: A multiplatform application that executes parallelized pipelines to analyse next-generation sequencing data

scientific article

RUbioSeq+: An Application that Executes Parallelized Pipelines to Analyse Next-Generation Sequencing Data

RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses

scientific article published on 28 April 2013

Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas

scientific article

SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.

scientific article

Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation

scientific article

Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells

scientific article published on 01 June 2019

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

scientific article published on June 2012

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

scientific article published on 21 December 2017

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.

scientific article published on 7 June 2016

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

scientific article

The Hippo Pathway Transducers YAP1/TEAD Induce Acquired Resistance to Trastuzumab in HER2-Positive Breast Cancer

scientific article published on 29 April 2020

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

scientific article published in January 2018

The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies

scientific article published on 22 May 2015

The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications

scientific article published on 01 November 2019

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

scientific article published on 19 May 2015

The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development.

scientific article published on 15 June 2012

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer

scientific article

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.

scientific article

Transcriptional characteristics of familial non-BRCA1/BRCA2 breast tumors.

scientific article

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

scientific article

Translational disease interpretation with molecular networks.

scientific article

Tumor microRNA expression profiling identifies circulating microRNAs for early breast cancer detection.

scientific article published on 8 June 2015

Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer

scientific article published on 6 April 2016

WhichGenes: a web-based tool for gathering, building, storing and exporting gene sets with application in gene set enrichment analysis

scientific article published on 30 April 2009

Whole genome analysis of p38 SAPK-mediated gene expression upon stress.

scientific article

miRGate: a curated database of human, mouse and rat miRNA-mRNA targets

scientific article

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors

scientific article

p21(Cip1) plays a critical role in the physiological adaptation to fasting through activation of PPARα.

scientific article published on 10 October 2016

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

scientific article published on 20 December 2018

vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer

scientific article published on 01 November 2019

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