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List of works by Jianling Xie

A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome.

scientific article published on 19 June 2017

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress

scientific article published on 19 March 2019

Bicuculline regulated protein synthesis is dependent on homer1 and promotes its interaction with eEF2K through mTORC1 dependent phosphorylation

scientific article published on 06 September 2020

Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells.

scientific article published on 14 May 2015

Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics

scientific article published on 13 July 2016

Cellular signalling of the receptor for advanced glycation end products (RAGE).

scientific article published on 06 July 2013

Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells.

scientific article published on 25 July 2016

Crosstalk between mTOR complexes.

scientific article published in November 2013

Cyclosporin A but not FK506 activates the integrated stress response in human cells

scientific article published on 24 August 2020

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

scientific article published on 02 November 2018

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

scientific article published on 18 January 2016

Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling

scientific article

Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3

scientific article published on 22 July 2019

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

scientific article published on 13 December 2017

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1.

scientific article

Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1.

scientific article published on August 2016

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival

scientific article

Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases.

scientific article published on 31 July 2010

Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling.

scientific article published on 09 August 2016

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2).

scientific article published in May 2012

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

scientific article published on 13 March 2020

Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

scientific article published on April 2015

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

scientific article published on 14 February 2019

Signaling crosstalk between the mTOR complexes

scientific article

The MAP kinase-interacting kinases (MNKs) as targets in oncology

scientific article published on 24 January 2019

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding

scientific article

The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4

scientific article published on 20 April 2020

The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis

scientific article published on 19 May 2020

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.

scientific article

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation

scientific article published on 28 May 2019

Trends in advanced glycation end products research in diabetes mellitus and its complications.

scientific article published on 23 March 2010

Who does TORC2 talk to?

scientific article published on 24 May 2018

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

scientific article

mTOR inhibitors in cancer therapy

scientific article

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation

scientific article published on 9 January 2017

mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.

scientific article published on 19 October 2016

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