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List of works by Gabriele Multhoff

(-)-Epigallocatechin-3-gallate, a green tea-derived catechin, synergizes with celecoxib to inhibit IL-1-induced tumorigenic mediators by human pancreatic adenocarcinoma cells Colo357.

scientific article

70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma.

scientific article published on 29 October 2015

A New Pharmacokinetic Model Describing the Biodistribution of Intravenously and Intratumorally Administered Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in a GL261 Xenograft Glioblastoma Model

scientific article published on 30 June 2020

A comparison of the effects of ifosfamide vs. mafosfamide treatment on intracellular glutathione levels and immunological functions of immunocompetent lymphocyte subsets

scientific article published in April 1997

A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells

scientific article

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

scientific article published on June 2016

A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.

scientific article published on 22 June 2011

A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells

scientific article published on 10 April 1995

AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro

scientific article published on 26 August 2015

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine

scientific article published on 21 December 2017

Activation of natural killer cells by heat shock protein 70. 2002.

scientific article published on May 2009

Adenosine can thwart antitumor immune responses elicited by radiotherapy : Therapeutic strategies alleviating protumor ADO activities

scientific article published on 9 March 2016

Adhesion molecule expression and function of primary endothelial cells in benign and malignant tissues correlates with proliferation

scientific article (publication date: 2014)

Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.

scientific article

Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.

scientific article published on September 2005

An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation

scientific article published in April 2008

An indicator quantitatively comparing two treatment effect sizes on responder and non-responder groups  -  exponential of estimated interaction parameter

scientific article published on 10 June 1996

Assisting the examination of large histopathological slides with adaptive forests

scientific article published on 5 October 2016

Autophagy contributes to resistance of tumor cells to ionizing radiation ⬇️

scientific article published on June 30, 2011

B-Cell-Based and Soluble Biomarkers in Body Liquids for Predicting Acute/Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

scientific article published on January 2016

Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics

scientific article published in February 2010

CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells.

scientific article published on August 1995

CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG).

scientific article

CXCR4 is a potential target for diagnostic PET/CT imaging in Barrett's dysplasia and esophageal adenocarcinoma.

scientific article published on 5 December 2017

Cell surface expression of heat shock proteins and the immune response ⬇️

scientific article published on September 1, 1996

Chronic inflammation in cancer development.

scientific article published in January 2011

Circulating microRNAs as prognostic therapy biomarkers in head and neck cancer patients

scientific article

Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors

scientific article published on 24 October 2019

Comment to: Humanization of a Mouse Monoclonal Antibody Directed Against a Cell Surface-Exposed Epitope of Membrane-Associated Heat Shock Protein 70 (Hsp70)

scientific article published on 29 July 2010

Commentary to: 'A comparison of two commercially available ELISA methods for the quantification of human plasma heat shock protein 70 during rest and exercise stress' by Lee et al. 2015.

scientific article published on 4 August 2015

Commentary: A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

scientific article published on 31 August 2016

Comparative analysis of the effects of radiotherapy versus radiotherapy after adjuvant chemotherapy on the composition of lymphocyte subpopulations in breast cancer patients

scientific article published in January 2016

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Contribution of the immune system to bystander and non-targeted effects of ionizing radiation

scientific article published on 15 October 2013

Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells.

scientific article published on May 2006

Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.

scientific article

Critical involvement of transmembrane tumor necrosis factor-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin

scientific article published in December 1995

Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance

scientific article

Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response ⬇️

scientific article published on March 1, 1998

Detection of experimental myocardium infarction in rats by MRI using heat shock protein 70 conjugated superparamagnetic iron oxide nanoparticle.

scientific article

Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment

scientific article published on 23 June 2011

Die Rolle der Strahlentherapie bei der Induktion von Antitumor-Immunantworten

scientific article published on 22 August 2012

Differences in Phosphorylated Histone H2AX Foci Formation and Removal of Cells Exposed to Low and High Linear Energy Transfer Radiation.

scientific article published on September 2012

Differential Hsp70 plasma-membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency ⬇️

scientific article published on September 11, 1998

Differential effects of ifosfamide on the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels

scientific article published on 15 April 1995

Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs

scientific article (publication date: 15 May 2004)

Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.

scientific article published on 17 December 2010

Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.

scientific article

Dual role of heat shock proteins (HSPs) in anti-tumor immunity.

scientific article

Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin

scientific article published on 18 October 2017

EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.

scientific article

Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels.

scientific article published on November 2002

Effects of definitive and salvage radiotherapy on the distribution of lymphocyte subpopulations in prostate cancer patients.

scientific article published on 12 May 2017

Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues

scientific article

Exercise-induced extracellular 72 kDa heat shock protein (Hsp72) stimulates neutrophil phagocytic and fungicidal capacities via TLR-2.

scientific article

Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally

scientific article

Extracellular cell stress proteins as biomarkers of human disease

scientific article

Frontiers research topic: radiation-induced effects and the immune system.

scientific article

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances

scientific article

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial

scientific article

Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer

scientific article

Heat shock and proinflammatory stressors induce differential localization of heat shock proteins in human monocytes

scientific article published on 01 December 1997

Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.

scientific article published on November 2003

Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells

scientific article published in November 1999

Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncolo

scientific article published on 13 December 2017

Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma

scientific article published in April 2003

Heat shock protein 70 membrane expression on fibroblast‐like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis

scientific article published on 01 November 2006

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

scientific article published on August 2004

Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma

scientific article

Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells

scientific article published on June 2005

Heat shock protein 72 (HSP72), a hyperthermia-inducible immunogenic determinant on leukemic K562 and Ewing's sarcoma cells.

scientific article published on January 1997

Heat shock proteins in cancer.

scientific article published on October 2007

Heat-shock protein 72 cell-surface expression on human lung carcinoma cells is associated with an increased sensitivity to lysis mediated by adherent natural killer cells

scientific article published on 17 December 1996

Heat-shock proteins and the immune response.

scientific article published in June 1998

Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients

scientific article

Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages.

scientific article

Hsp70--a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck

scientific article

Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff, International Journal of Hyperthermia, 2002;18:576-585.

scientific article published in May 2009

Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA)

scientific article published on April 2010

Ifosfamide induced stress response in human lymphocytes

scientific article published in January 1993

Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles

scientific article published on 8 September 2015

Immune Cell Phenotyping Using Flow Cytometry

scientific article published on 2 November 2015

Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.

scientific article published in January 2018

Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies

scientific article

Immunostimulatory functions of membrane-bound and exported heat shock protein 70.

scientific article

Improved normal tissue protection by proton and X-ray microchannels compared to homogeneous field irradiation.

scientific article published on 27 April 2015

In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody.

scientific article published on April 2011

Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams.

scientific article

Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells.

scientific article published on 26 February 2008

Influence of bacterial endotoxin on the allogenicity of human endothelial cells

scientific article published in June 1998

Influence of tumors on protective anti-tumor immunity and the effects of irradiation.

scientific article published on February 2013

Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells.

scientific article published on October 2002

Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction.

scientific article published on 29 January 2015

Interleukin-10 promotes NK cell killing of autologous macrophages by stimulating expression of NKG2D ligands.

scientific article published in October 2010

Interleukin-33 acts as a pro-inflammatory cytokine and modulates its receptor gene expression in highly metastatic human pancreatic carcinoma cells.

scientific article

Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy.

scientific article published on 24 August 2006

Investigating cellular stress responses--a multidisciplinary approach from basic science to therapeutics--report on the EuroSciCon (European Scientific Conferences) meeting.

scientific article published on January 2007

Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).

scientific article published on 24 November 2015

Irradiation-induced regulation of plasminogen activator inhibitor type-1 and vascular endothelial growth factor in six human squamous cell carcinoma lines of the head and neck.

scientific article

Irradiation-induced up-regulation of HLA-E on macrovascular endothelial cells confers protection against killing by activated natural killer cells

scientific article

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

scientific article published on January 2014

Label-free nondestructive discrimination of colon carcinoma sublines and biomolecular insights into their differential Hsp70 expression: DNA/RNA nucleobase specific changes.

scientific article published on 7 July 2011

Late proliferating and inflammatory effects on murine microvascular heart and lung endothelial cells after irradiation

scientific article published on 29 July 2015

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

scientific article published in November 2001

Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential

scientific article

Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness

scientific article published on 7 September 2012

Magnetic heating properties and neutron activation of tungsten-oxide coated biocompatible FePt core–shell nanoparticles

scientific article published on 11 November 2014

Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists

scientific article published on 22 September 2017

Membrane heat shock protein 70: a theranostic target for cancer therapy

scientific article published in January 2018

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

scientific article

Membrane-associated stress proteins: more than simply chaperones.

scientific article published on 05 March 2008

Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells

scientific article published in April 2003

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

Molecular chaperones in biology and medicine at Obernai

scientific article

Monitoring PAI-1 and VEGF levels in 6 human squamous cell carcinoma xenografts during fractionated irradiation.

scientific article

NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T-cells.

scientific article

NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells

scientific article published on 18 February 2015

Natural killer cells activity and neuroimmunological treatment of cancer.

scientific article published in December 2004

Neue Perspektiven in der Behandlung des nicht kleinzelligen Lungenkarzinoms (NSCLC)

scientific article published in 2006

Non-targeted effects of photon and particle irradiation and the interaction with the immune system.

scientific article published on 24 July 2012

Noncytotoxic alkyl-lysophospholipid treatment increases sensitivity of leukemic K562 cells to lysis by natural killer (NK) cells

scientific article published in March 1996

Noradrenaline increases the expression and release of Hsp72 by human neutrophils.

scientific article

Nucleofection of non-B cells with mini-Epstein-Barr virus DNA.

scientific article

Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas

scientific article published on 28 August 2017

P67. Targeted natural killer (NK) cell based adoptive immunotherapy for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCT) – clinical application of NK cells activated by heat shock protein 70 (Hsp70).

scientific article

PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics

scientific article

Patient survival by Hsp70 membrane phenotype

scientific article published in 2007

Peripheral blood mononuclear cells induce programmed cell death in human endothelial cells and may prevent repair: role of cytokines

scientific article published on 15 March 1997

Plasma exosomes protect the myocardium from ischemia-reperfusion injury.

scientific article published in April 2015

Plasmodium falciparum-infected erythrocytes induce granzyme B by NK cells through expression of host-Hsp70.

scientific article

Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model.

scientific article

Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages

scientific article published in October 2011

Radiation, inflammation, and immune responses in cancer

scientific article

Radiation-Induced Stress Proteins - the Role of Heat Shock Proteins (HSP) in Anti- Tumor Responses ⬇️

scientific article published on January 1, 2012

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors.

scientific article published on 15 November 2012

Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922

scientific article published on 28 September 2019

Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α

scientific article

Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels ⬇️

scientific article published on August 30, 2012

Rationale of hyperthermia for radio(chemo)therapy and immune responses in patients with bladder cancer: Biological concepts, clinical data, interdisciplinary treatment decisions and biological tumour imaging.

scientific article

Recent Developments of Magnetic Nanoparticles for Theranostics of Brain Tumor.

scientific article

Reduced side effects by proton microchannel radiotherapy: study in a human skin model

scientific article published on 28 December 2012

Retinoid- and sodium-butyrate-induced decrease in heat shock protein 70 membrane-positive tumor cells is associated with reduced sensitivity to natural killer cell lysis, growth delay, and altered growth morphology

scientific article

Role of membrane Hsp70 in radiation sensitivity of tumor cells

scientific article published on 22 July 2015

Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.

scientific article published on 27 November 2017

Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe

scientific article published on 9 October 2014

Sensitizing tumor cells to radiation by targeting the heat shock response.

scientific article

Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses.

scientific article published on 20 December 2011

Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts

scientific article

Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses.

scientific article

Sub-micrometer 20MeV protons or 45MeV lithium spot irradiation enhances yields of dicentric chromosomes due to clustering of DNA double-strand breaks.

scientific article published on 29 July 2015

Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells

scientific article published in March 1999

Targeted and theranostic applications for nanotechnologies in medicine

Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells.

scientific article published on 2 September 2013

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

scientific article

The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition.

scientific article

The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA

scientific article published on 19 November 2015

The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

scientific article published on 08 May 2017

The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?

scientific article published on 9 April 2009

The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells.

scientific article published on January 2004

The effects of ultra-high dose rate proton irradiation on growth delay in the treatment of human tumor xenografts in nude mice

scientific article

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.

scientific article published on April 2010

The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation

scientific article

The role of heat shock proteins in the stimulation of an immune response

scientific article published on March 1, 1998

The role of recent nanotechnology in enhancing the efficacy of radiation therapy

scientific article published on 02 July 2015

The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.

scientific article published on 05 February 2008

Three-dimensional imaging of whole mouse models: comparing nondestructive X-ray phase-contrast micro-CT with cryotome-based planar epi-illumination imaging.

scientific article published on 15 November 2013

Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.

scientific article

Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide

scientific article

Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3.

scientific article

Tumour infiltrating host cells and their significance for hyperthermia.

scientific article published on January 2010

Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models.

scientific article published on March 2014

What opportunities does Immuno-oncology indicate for overarching long-term survival?

scientific article published on 28 April 2015

Zero-valent Fe confined mesoporous silica nanocarriers (Fe(0) @ MCM-41) for targeting experimental orthotopic glioma in rats.

scientific article published on 08 July 2016

[Screening of gene polymorphisms does not improve predictability of radiation toxicity].

scientific article published in January 2013

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