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List of works by Stefan Rose-John

"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells

scientific article published on 6 December 2013

1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.

scientific article published in July 2004

A New Type of Cytokine Receptor Antagonist Directly Targeting gp130

scientific article published on 01 October 1998

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.

scientific article published on 29 May 2015

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

scientific article published on 01 February 1997

A designer hyper interleukin 11 (H11) is a biologically active cytokine.

scientific article

A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3)

scientific article published on 11 October 2013

A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis

scientific article published on March 2016

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor

scientific article (publication date: 6 June 2014)

A key role for gp130 expressed on peripheral sensory nerves in pathological pain.

scientific article

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor ⬇️

scientific article published on December 1, 1995

A new hepatocyte stimulating factor: cardiotrophin-1 (CT-1)

scientific article published on 01 September 1995

A new multiple trauma model of the mouse

scientific article published on 21 November 2017

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population

article

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

scientific article

A role for IL-27p28 as an antagonist of gp130-mediated signaling

scientific article

A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding

scientific article published on July 1999

A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing

scientific article published on 22 January 2016

A switch from white to brown fat increases energy expenditure in cancer-associated cachexia

scientific article published on 17 July 2014

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

scientific article published on 11 June 2020

ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation

scientific article published on 20 July 2020

ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis

scientific article published on 14 September 2014

ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro

scientific article published on January 2007

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses

scientific article

ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.

scientific article published on 12 December 2013

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

scientific article published on 22 February 2018

ADAM17 substrate release in proximal tubule drives kidney fibrosis

scientific article published on August 2016

ADAM17, shedding, TACE as therapeutic targets ⬇️

scientific article published on February 13, 2013

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase

scientific article

ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates

scientific article published in September 2012

ADAM17: a molecular switch to control inflammation and tissue regeneration

scientific article published on 13 July 2011

ALTERED PULMONARY INTERLEUKIN-6 SIGNALING IN PRETERM INFANTS DEVELOPING BRONCHOPULMONARY DYSPLASIA

scientific article published on 01 December 2008

AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS

scientific article published on 01 September 2000

Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display

scientific article published in September 2006

Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing

scientific article

Activation of gp 130 by IL-6/soluble IL-6 receptor induces neuronal differentiation

scientific article published on 01 December 1997

Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration

scientific article published on October 2010

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

scientific article published on 11 March 2014

Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat.

scientific article published on 27 January 2015

Acute-phase response factor, increased binding, and target gene transcription during liver regeneration.

scientific article

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice

scientific article published on 22 December 2016

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.

scientific article published on 28 April 2015

Alternative assay procedures for cytokines and soluble receptors of the IL-6 family

scientific article published on 01 September 1996

An analysis of the function and expression of D6 on lymphatic endothelial cells

scientific article

An evaluation of 2,5-norbornadiene as a reversible inhibitor of ethylene action in deepwater rice

article

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

scientific article published on 3 December 2012

Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M

article

Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines

scientific article published in May 2003

Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages

scientific article

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

scientific article published on 13 June 2007

Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice

scientific article published on November 2000

Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons

scientific article

Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.

scientific article published on 2 April 2015

Biosynthesis and distribution of leucocyte elastase inhibitor. Production of recombinant inhibitor.

scientific article

Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130.

scientific article published on July 1994

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

article

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

scientific article

Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro

scientific article published on 01 April 1988

CDP-870. Celltech/Pfizer.

scientific article

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

scientific article published on 9 April 2006

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

scientific article

Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source

scientific article published on 2 March 2016

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

scientific article

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

scientific article published on 18 September 2013

Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes

scientific article (publication date: 21 December 1992)

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation

scientific article

Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair

scientific article published on 21 November 2016

Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo

scientific article published in July 2007

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

scientific article published on 6 May 2016

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

scientific article

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

scientific article published on 01 December 2000

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins ⬇️

scientific article published on September 15, 1992

Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress

scientific article

Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response

scientific article published on 30 July 2016

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling

scientific article published on April 2012

Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis

scientific article

Coordination of interleukin-6 biology by membrane bound and soluble receptors

scientific article published on 01 January 2001

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

scientific article published on 01 March 2017

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

scientific article

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells

scientific article published on 01 August 2007

Cytokines as therapeutic drugs

scientific article

Cytokines come of age.

scientific article published in November 2002

Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth

scientific article published in December 2002

Dendritic cell development requires histone deacetylase activity

scientific article published on 16 June 2014

Dendritic cell lineage commitment is instructed by distinct cytokine signals

scientific article published on 9 November 2011

Designer cytokines for human haematopoietic progenitor cell expansion: impact for tissue regeneration.

scientific article

Designing cytokine variants by phage-display

scientific article

Development of a human interleukin-6 receptor antagonist.

scientific article published on January 1994

Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition

scientific article published in August 2004

Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.

scientific article published on December 1994

Devic disease: Translational medicine at work

scientific article published on 14 March 2014

Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling

scientific article

Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo

scientific article published in May 1988

Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.

scientific article

Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor

scientific article

Differential shedding of the two subunits of the interleukin-6 receptor

scientific article published on 01 October 1993

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

scientific article published on 19 July 2010

Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy

scientific article (publication date: 2 January 2004)

Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer

scientific article published in January 2018

Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing

scientific article published on 13 November 2017

Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

scientific article

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

scientific article published on May 1996

Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth

scientific article published on 22 September 2016

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

scientific article published on March 2005

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

scientific article published on 8 April 2017

ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.

scientific article

Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation

scientific article published on 31 October 2010

Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts

scientific article published on 01 October 1996

Effect of submergence on the cell wall composition of deep-water rice internodes

article

Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice

scientific article published on 7 December 2012

Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin

scientific article published in October 2000

Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application

scientific article

Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep

scientific article

Enzymatically Degraded, Nonoxidized LDL Induces Human Vascular Smooth Muscle Cell Activation, Foam Cell Transformation, and Proliferation

scientific article published on 01 April 2000

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published in Nature Communications

Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling

Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model

scientific article

Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat.

scientific article published on December 1995

Expression of the kinase domain of mouse protein kinase C in E. coli.

scientific article

Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

scientific article published on February 1997

Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis

scientific article published on 15 September 2017

Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons

scientific article published on 7 April 2005

Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism.

scientific article published on December 2006

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells

scientific article

Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth

scientific article published on 16 June 2010

Frontline Science: Proliferation of Ly6C(+) monocytes during urinary tract infections is regulated by IL-6 trans-signaling

scientific article published on 7 September 2017

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation ⬇️

scientific article published on 04 May 2019

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain

scientific article published on 30 October 2020

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

article

Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130.

scientific article published on July 1995

Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling

scientific article published on September 2006

G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation

scientific article published on 16 November 2009

GP130 activation induces myeloma and collaborates with MYC.

scientific article published on 10 November 2014

GP130 stimulation and the maintenance of stem cells

scientific article published on 01 October 2002

Generation and function of the soluble interleukin-6 receptor.

scientific article

Generation of tumor-reactive CTL against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hemopoietic progenitor cells.

scientific article

Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells

scientific article published on 01 September 2004

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

scientific article

Genetically modified tumour vaccines (GMTV) in melanoma clinical trials

scientific article published on 01 September 2000

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

scientific article published on 8 May 2014

Gp130-Signaling synergizes with FL and TPO for the long-term expansion of cord blood progenitors

scientific article published on 01 December 1999

HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice

scientific article

Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice

scientific article published on August 1998

Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.

scientific article

Hitting a complex target: an update on interleukin-6 trans-signalling

scientific article published on February 2012

Human CNTF and related cytokines: effects on DRG neurone survival

scientific article published on 01 December 1995

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

scientific article

Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells

scientific article published in June 2000

Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells

scientific article

Human interleukin-6 facilitates hepatitis B virus infection in vitro and in vivo.

scientific article

Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor

article

Hyper-IL-6 gene therapy reverses fulminant hepatic failure.

scientific article

IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling

scientific article published on 2 December 2011

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

scientific article published in April 2017

IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

scientific article published on 01 May 2000

IL-6 Trans-Signaling Drives Murine Crescentic GN

scientific article

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease

scientific article published on 02 July 2020

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

scientific article published on 01 June 2001

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

scientific article (publication date: 3 February 2009)

IL-6 biology: implications for clinical targeting in rheumatic disease

scientific article

IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

scientific article published on 21 February 2015

IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling

scientific article

IL-6 pathway in the liver: From physiopathology to therapy

scientific article

IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts

scientific article published on 8 April 2008

IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions

scientific article published on 25 September 2013

IL-6 signaling promotes tumor growth in colorectal cancer

scientific article published on 03 February 2005

IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer

scientific article published on December 2010

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

scientific article published on 22 October 2016

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells

scientific article

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

scientific article published on 10 December 2010

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

scientific article published on 15 February 2013

IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.

scientific article published on 24 October 2012

IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function

scientific article published on 4 September 2014

IL-6 trans-signaling: the heat is on.

scientific article published on January 2004

IL-6 transsignaling: the in vivo consequences

scientific article

IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

scientific article

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

scientific article

IL-6-trans-signalling increases rapid-eye-movement sleep in rats

scientific article

IL-6/IL-6R axis plays a critical role in acute kidney injury

scientific article published on 12 March 2008

IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.

scientific article published on 7 January 2016

IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice

scientific article published on 21 December 2007

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

scientific article

Identification of Single Amino Acid Residues of Human IL-6 Involved in Receptor Binding and Signal Initiation

scientific article published on 01 August 1996

Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor

scientific article published on 01 July 1994

Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor

scientific article published on 14 May 2013

Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.

scientific article

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

scientific article published on August 1994

Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6

scientific article published on 01 March 1999

Immunogene therapy of human melanoma. Phase I/II clinical trial

scientific article published in January 1998

Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration

scientific article published on 29 August 2009

Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice

scientific article published in June 2009

In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130.

scientific article published in June 2001

In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6 ⬇️

scientific article published on October 1, 1998

In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli

scientific article

Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis

scientific article published on 7 May 2010

Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.

scientific article published on 18 May 2010

Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.

scientific article

Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.

scientific article

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.

scientific article published on 5 February 2015

Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer

scientific article published on 29 January 2015

Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling

scientific article published in October 2004

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

scientific article published on 11 October 2011

Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.

scientific article published on April 2014

Instructive Role of the Microenvironment in Preventing Renal Fibrosis

scientific article

Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production

scientific article

Interferon-gamma regulates alpha 2-macroglobulin and alpha 1-antichymotrypsin expression on the pretranslational level in HepG2 cells

scientific article published on January 1, 1992

Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease

scientific article published on 23 October 2014

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.

scientific article published on 17 October 2007

Interleukin 6 trans-signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole-induced seizures in mice

scientific article

Interleukin 6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis

scientific article published on 27 December 2016

Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.

scientific article published on April 2016

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.

scientific article published on February 2017

Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells

scientific article published on 5 December 2006

Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons

scientific article published on 01 February 1999

Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients

scientific article published in December 1997

Interleukin-6 Family Cytokines

scientific article published on 15 June 2017

Interleukin-6 Trans-Signaling Regulates Glycogen Consumption After d-Galactosamine-Induced Liver Damage

scientific article published on 01 November 2009

Interleukin-6 and its receptor: from bench to bedside

scientific article

Interleukin-6 and its receptors: a highly regulated and dynamic system

scientific article published on 28 June 2014

Interleukin-6 and neural stem cells: more than gliogenesis

scientific article published on 29 October 2008

Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis

scientific article published on 01 November 1998

Interleukin-6 biology is coordinated by membrane bound and soluble receptors.

scientific article published on January 2003

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

scientific article

Interleukin-6 in sepsis and capillary leakage syndrome

scientific article published on 02 December 2011

Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.

scientific article published on 6 January 2016

Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells

scientific article

Interleukin-6 receptor-interleukin-6 fusion proteins with enhanced interleukin-6 type pleiotropic activities

scientific article published on 01 December 1997

Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling

scientific article published on 6 November 2007

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease

scientific article published on January 2009

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease

scientific article published on 24 October 2012

Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice

scientific article published in October 2013

Interleukin-6 trans-signaling in inflammatory bowel disease

scientific article

Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells

scientific article published on 16 December 2015

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

scientific article published on 05 October 2020

Interleukin-6: Biology, signaling and strategies of blockade

scientific article published on 04 July 2015

Interleukin-6: a villain in the drama of pancreatic cancer development and progression

scientific article published on August 2014

Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities

scientific article published on 08 December 2013

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

scientific journal article

Intracellular retention of interleukin-6 abrogates signaling.

scientific article

Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice

scientific article

Introduction to stem cell biology in vitro. Threshold to the future.

scientific article

Is Interleukin-6 Receptor Blockade the Holy Grail for Inflammatory Diseases?

article

Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles

scientific article published on 24 May 2020

KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.

scientific article published on 26 February 2016

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

scientific article

Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis

scientific article published in Scientific Reports

Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130

scientific article published on 01 August 1995

Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6

article

Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.

scientific article published in October 2000

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

scientific article published on 23 December 2016

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells

scientific article published on 11 May 2007

Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection

scientific article published on 01 June 2012

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells

scientific article published on 18 January 2010

Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.

scientific article published on 18 March 2016

Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

scientific article

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

scientific article published on August 2016

Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction.

scientific article published on July 1995

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

scientific article published on 09 March 2017

Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.

scientific article published on 29 April 2014

Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: comparison with human monocytes, fibroblasts and endothelial cells.

scientific article published on April 1990

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

scientific article published on 9 October 2017

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells

scientific article published on 16 January 2017

Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes ⬇️

scientific article published on July 1, 1993

Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts.

scientific article

More about genetically modified tumour vaccines.

scientific article

Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions

scientific article published in July 2013

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

scientific article published in November 2017

Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells

scientific article published on 15 December 2005

Murine stromal cells producing hyper-interleukin-6 and Flt3 ligand support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors

scientific article published on 01 October 2002

Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency

scientific article

Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.

scientific article published on 7 February 2015

N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

scientific article

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy

scholarly article

Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).

scientific article

New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?

scientific article published on 01 September 1999

New insights into the role and signalling processes of gp130.

scientific article

New perspectives on the design of cytokines and growth factors.

scientific article

No inhibition of IL-27 signaling by soluble gp130.

scientific article

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

scientific article published in December 2009

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography

scientific article published on 3 October 2016

Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets

scientific article

Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor

scientific article

Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor

scientific article

Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action

scientific article

Oncogenic deletion mutants of gp130 signal from intracellular compartments

scientific article published on 08 November 2013

Oncostatin M, leukaemia-inhibitory factor and interleukin 6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells

scientific article published on January 1998

Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation

scientific article published on February 2007

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

scientific article

Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.

scientific article

Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts

scientific article published on 20 August 2016

Participation of Two Ser-Ser-Phe-Tyr Repeats in Interleukin-6 (IL-6)-Binding Sites of the Human IL-6 Receptor

scientific article published on 01 June 1996

Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture

scientific article published on 2 July 2015

Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.

scientific article

Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome

scientific article published on 8 December 2014

Plasticity and cross-talk of interleukin 6-type cytokines

scientific article published on 15 May 2012

Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding

scientific article published on 13 December 2013

Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from Embryonic Stem Cells

article

Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.

scientific article published on July 1996

Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro

scientific article published in March 2005

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

scientific article published on December 1992

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

scientific article published on 10 February 2016

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

scientific article

Proteolytic steps within signaling cascades make these signaling pathways irreversible

scientific article published on 24 August 2017

RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity

scientific article published on September 2015

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

scientific article published on 11 June 2014

Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

scientific article

Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.

scientific article

Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction

scientific article

Recombinant human single chain Fv antibodies recognizing human interleukin-6. Specific targeting of cytokine-secreting cells

scientific article published in January 1998

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35

scientific article

Recombinant soluble human interleukin-6 receptor. Expression in Escherichia coli, renaturation and purification

scientific article published on August 1993

Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12.

scientific article published in October 2002

Regulation of Fibrotic Processes in the Liver by ADAM Proteases

scientific article published on 09 October 2019

Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10

article

Regulation of the type II oncostatin M receptor expression in lung-derived epithelial cells

scientific article published in June 1998

Residues 77-95 of the human interleuken-6 protein are responsible for receptor binding and residues 41-56 for signal transduction

scientific article published on 01 July 1995

Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression.

scientific article published in November 1998

Role of IL-6 trans-signaling in CCl₄induced liver damage

scientific article published on 3 August 2010

Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression

scientific article published in May 1999

STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

scientific article published on 8 May 2006

STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published on 22 July 2015

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

article

Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6

scholarly article by Andreas Reif et al published 22 September 2014 in Angewandte Chemie International Edition

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

scientific article published on 30 July 2014

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

scientific article published on 10 September 2015

Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins

scientific article published on May 2000

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

scientific article published on 14 October 2013

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

scientific article

Site-directed mutagenesis of human CNTF: Functional analysis of recombinant variants

scientific article published on 01 April 1995

Sleep enhances IL-6 trans-signaling in humans

scientific article published on 15 August 2006

Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

scientific article published on 01 September 2003

Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.

scientific article

Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine

scientific article published on 25 November 2013

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

scientific journal article

Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization

scientific article published on December 1995

Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of alpha 1-protease inhibitor secreted by HepG2 cells

scientific article published on July 20, 1992

Soluble interleukin-6 receptor (sIL-6R) makes IL-6R negative T cell line respond to IL-6; it inhibits TNF production.

scientific article

Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.

scientific article

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

scientific article published on 15 March 2011

Stabilized Interleukin-6 receptor binding RNA aptamers

scientific article published on 20 December 2013

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

article

Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures

scientific article

Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system

scientific article

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

article

Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells

scientific article

Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA.

scientific article published on February 1991

Structure of an extracellular gp130 cytokine receptor signaling complex

scientific article

Structure-function analysis of human interleukin-6. Evidence for the involvement of the carboxy-terminus in function.

scientific article published on March 1990

Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding

scientific article published on 01 July 1993

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

scientific article published on 23 July 2008

Studies on the structure and regulation of the human hepatic interleukin-6 receptor

scientific article published on 01 May 1990

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

scientific article published on 10 November 2017

Sympathetic neurons can produce and respond to interleukin 6

scientific article

Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1

scientific article published on November 23, 1992

Synthetic Mimetics of the gp130 Binding Site for Viral Interleukin-6 as Inhibitors of the vIL-6-gp130 Interaction

T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding

scientific article published on 19 November 2013

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

scientific article published in October 2004

TIMP expression in toxic and cholestatic liver injury in rat

article

TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes

scientific article published on 01 July 1995

TIMP-1 protein expression is stimulated by IL-1β and IL-6 in primary rat hepatocytes

scientific article published on 01 July 1994

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

scientific article published on September 2008

TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species

scientific article

TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis

scientific article published on 11 June 2013

The ADAM17 Metalloproteinase Maintains Arterial Elasticity.

scientific article published on 5 January 2018

The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury

scientific article published on 3 March 2005

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

scientific article

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

scientific article published on May 2007

The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons.

scientific article published on May 1999

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

scientific article

The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

scientific article published in May 2005

The Membrane Proximal Cytokine Receptor Domain of the Human Interleukin-6 Receptor Is Sufficient for Ligand Binding but Not for gp130 Association ⬇️

scientific article published on August 14, 1998

The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets

scientific article

The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation

scientific article published on 4 July 2017

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

scientific article published on 6 May 2014

The balance between Treg and TH17 cells: CD11b and interleukin-6.

scientific article published in April 2017

The biology of interleukin-6 in the 21st century

scientific article published on 18 February 2014

The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.

scientific article published on January 1999

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

scientific article

The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons

scientific article published in July 2002

The function of the soluble IL-6 receptor in vivo

scientific article published on 01 December 1996

The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells

scientific article published on 01 April 2000

The hepatic interleukin-6 receptor Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand

scientific article published on 01 July 1992

The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone

scientific article published on 01 February 1993

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

scientific article published on 26 October 2017

The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane

scientific article

The interleukin 6 pathway and atherosclerosis

scientific article published on 01 July 2012

The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis

scientific article published in July 2004

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

scientific article

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II

scientific article published on 21 March 2012

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

scientific article published on 04 February 2011

The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

scientific article published on 12 May 2016

The regenerative activity of interleukin-6.

scientific article

The role of ADAM17 in the T-cell response against bacterial pathogens

scientific article published on 6 September 2017

The role of IL-6 in host defence against infections: immunobiology and clinical implications

scientific article published on 15 June 2017

The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model

scientific article

The role of interleukin-6 signaling in nervous tissue

scientific article published on 22 March 2016

The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses

scientific article

The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex

scientific article

The shedding protease ADAM17: Physiology and pathophysiology

scientific article published on 10 July 2017

The soluble Interleukin 6 receptor: generation and role in inflammation and cancer

scientific article published on 08 December 2010

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site

scientific article published on 01 May 1994

The soluble interleukin-6 receptor

scientific article published on 01 July 1995

The soluble interleukin-6 receptor and related proteins

scientific article

The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor

scientific article published on 01 September 2006

The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling

scientific article published on 22 December 2011

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution

scientific article published on 30 October 2010

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

scientific article published on September 2012

The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.

scientific article published on July 2008

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

scientific article

The transcription factor repertoire of Flt3+ hematopoietic stem cells

scientific article

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10

scientific article

The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex

scientific article published on January 2002

Therapeutic Blockade of Interleukin-6 in Chronic Inflammatory Disease

scientific article published on April 1, 2012

Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

scientific article published on 2 July 2016

Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage

scientific article published on 14 December 2018

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

scientific article

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

scientific article

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis

scientific article published on 20 January 2012

Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2.

scientific article published on January 1995

Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling

scientific article

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

article

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

scientific article

Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis

scientific article

Transcriptional profiling identifies Id2 function in dendritic cell development

scientific article

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

scientific article published on 7 November 2007

Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.

scientific article

Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

scientific article published on 10 November 2011

Trp53 deficiency protects against acute intestinal inflammation

scientific article published on 14 June 2013

Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages

scientific article

Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor

scientific article published on 4 March 2009

Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.

scientific article

Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells

scientific article published on February 10, 1992

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

scientific article

Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex

scientific article published on 13 August 2014

Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation

scientific article published on 01 September 2005

Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization

scientific article published on 21 December 2010

Virokines in the pathogenesis of cancer: focus on human herpesvirus 8.

scientific article

Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma

scientific article

Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate

scientific article published on 15 September 2020

Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor

scientific article published on 01 November 1996

Zytokine: Biologie und therapeutische Relevanz

scientific article published on 01 June 1996

d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers

scientific article

gp130 activation is regulated by D2-D3 interdomain connectivity

scientific article published in March 2013

gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes

scientific article published on 6 June 2006

gp130-stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells.

scientific article

mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.

scientific article

“Family reunion” – A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines

article

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