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List of works by David W. Ray

A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis.

scientific article published on May 2004

A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function ⬇️

scientific article published on 17 May 2013

A matter of time: study of circadian clocks and their role in inflammation

scientific article published on 8 February 2016

A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response

scientific article published on 21 September 2017

A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study

scientific article published on 3 May 2011

Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

scientific article published on 25 January 2016

Addressing Indonesia’s Infrastructure Deficit

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

scientific article published on 05 August 2021

Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit

scientific article

An abnormality in glucocorticoid receptor expression differentiates steroid responders from nonresponders in keloid disease ⬇️

scientific article published on 24 February 2015

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

scientific article

An improved method for quantitative ChIP studies of nuclear receptor function

scientific article published on 01 May 2019

Analysis of co-factor function in a glucocorticoid-resistant small cell carcinoma cell line.

scientific article

Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes

scientific article published in March 2004

Biological and clinical insights from genetics of insomnia symptoms

scientific article published on 25 February 2019

CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in CD8 cells from COPD patients

scientific article

Cardiac mitochondrial function depends on BUD23 mediated ribosome programming

scientific article published on 15 January 2020

Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling

scientific article published on 01 January 2019

Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program

scientific article

Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection.

scientific article published on 12 June 2019

Cell cycle phase regulates glucocorticoid receptor function ⬇️

scientific article

Characterization of conserved tandem donor sites and intronic motifs required for alternative splicing in corticosteroid receptor genes

scientific article published on 9 October 2009

Characterization of the molecular genetic pathology in patients with 11β-hydroxylase deficiency

scientific article published on 6 June 2015

Chronic glucocorticoid exposure potentiates placental chorionic plate artery constriction: implications for aberrant fetoplacental vascular resistance in fetal growth restriction.

scientific article

Circadian Biology: Rhythms Leave Their Imprint

scientific article published on 01 March 2015

Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits

scientific article published on 19 October 2019

Circadian asthma airway responses are gated by REV-ERBα

scientific article published on 25 June 2020

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

scientific article published on 13 March 2018

Circadian rhythm of exhaled biomarkers in health and asthma

scientific article published on 17 October 2019

Circadian rhythms in innate immunity and stress responses

scientific article published on 10 December 2019

Circadian timing in the lung; a specific role for bronchiolar epithelial cells

scientific article

Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells ⬇️

article

Correction: Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells

scientific article published in PLoS ONE

Corticosteroid effects on COPD alveolar macrophages: dependency on cell culture methodology

scientific article published on 12 February 2014

Corticosteroid-binding globulin regulates cortisol pharmacokinetics

scientific article published in January 2011

Cunning factor: macrophage migration inhibitory factor as a redox-regulated target

scientific article

Current concepts in glucocorticoid resistance

scientific article published on 20 June 2012

Cushing's syndrome due to phaeochromocytoma secreting the precursors of adrenocorticotropin

scientific article published on 01 December 2000

Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force

scientific article published on March 2016

Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735

scientific article (publication date: May 2003)

Drug insight: selective agonists and antagonists of the glucocorticoid receptor

scientific article published on February 2008

EULAR evidence-based and consensus-based recommendations on the management of medium to high-dose glucocorticoid therapy in rheumatic diseases.

scientific article

Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

scientific article published on 17 January 2018

Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock

scientific article

Effect of rapamycin and prednisolone in differentiated THP-1 and U937 cells.

scientific article published in November 2002

Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate

scientific article

Familial glucocorticoid resistance caused by a novel frameshift glucocorticoid receptor mutation.

scientific article

Functioning of the hypothalamic-pituitary-adrenal and growth hormone axes in frequently unexplained disorders: results of a population study.

scientific article published on 23 October 2013

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

scientific article published in Nature Communications

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

scientific article published on 19 December 2016

Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

scientific article published on 9 March 2016

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

scientific article published on 13 August 2019

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

article

Genome-wide effect of pulmonary airway epithelial cell–specific Bmal1 deletion

scientific article published on 22 February 2019

Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain

scientific article published in Journal of Biological Chemistry

Glucocorticoid receptor function in health and disease. ⬇️

scientific article

Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis

scientific article

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production ⬇️

scientific article

Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth

scientific article

Glucocorticoid receptor overexpression exerts an antisurvival effect on human small cell lung cancer cells.

scientific article published on 14 May 2007

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

scientific article published on 6 April 2015

Glucocorticoid receptors in lung cancer: new perspectives

scientific article

Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype

scientific article published in February 2004

Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1

scientific article published on 27 July 2017

Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway

scientific article published on 07 May 2020

Glucocorticoids reduce inflammation in cystic fibrosis bronchial epithelial cells.

scientific article published on 17 January 2012

Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type-specific manner.

scientific article

How Do Glucocorticoids Used in Rheumatic Disease Affect Body Weight? A Narrative Review of the Evidence

scientific article published on 01 April 2020

Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?

scientific article published on 7 August 2006

Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression

scientific article

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor

scientific article

Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin.

scientific article

Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation

scientific article

Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis

scientific article

Impaired processing of proopiomelanocortin in corticotroph macroadenomas

scientific article published on 01 February 1996

Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-me

scientific article

Interferon-inducible factor 16 is a novel modulator of glucocorticoid action ⬇️

scientific article

Leukemia Inhibitory Factor Regulates Proopiomelanocortin Transcriptiona ⬇️

scientific article published on May 1, 1998

Leukemia inhibitory factor as an intrapituitary mediator of ACTH secretion.

scientific article

Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner

scientific journal article

Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells ⬇️

scientific article

Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records

article

MIF Alleles in Inflammatory Arthritis

MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation

scientific article

Macrophage Migration Inhibitory Factor Gene Polymorphism is Associated with Psoriasis

scientific article published on 01 September 2004

Misalignment with the external light environment drives metabolic and cardiac dysfunction

scientific article published on 12 September 2017

Modelling the glucocorticoid receptor and producing therapeutic agents with anti-inflammatory effects but reduced side-effects

scientific article published on 30 November 2006

Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study

scientific article

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

scientific article published on 01 October 2018

Molecular mechanisms of glucocorticoid resistance

scientific article published on 01 April 1996

Monthly variance in UK renal transplantation activity: a national retrospective cohort study

scientific article published on 17 September 2019

Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis

scientific article published on September 2002

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

scientific article

NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms

scientific article published on 06 May 2003

Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism

scientific article published on 28 September 2020

Optimized chemical probes for REV-ERBα.

scientific article published on 23 May 2013

Ovarian Leydig cell tumor in a peri-menopausal woman with severe hyperandrogenism and virilization.

scientific article published on October 2005

Paracrine interactions within the pituitary gland.

scientific article published in May 1998

Paraneoplastic Syndromes

Pin1 promotes GR transactivation by enhancing recruitment to target genes ⬇️

scientific article published on 25 July 2013

Poor sleep and depression are independently associated with a reduced pain threshold. Results of a population based study

scientific article published on 19 April 2005

Pressure pain thresholds and tender point counts as predictors of new chronic widespread pain in somatising subjects.

scientific article published on 29 September 2006

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians

scientific article published in August 2006

REVERBa couples the circadian clock to hepatic glucocorticoid action ⬇️

scientific article published on 04 September 2018

Real-time analysis of gene regulation by glucocorticoid hormones

scientific article published on May 2008

Reduced glucocorticoid receptor expression and function in airway neutrophils

Regulation of cortisol bioavailability--effects on hormone measurement and action

scientific article published on 14 August 2012

Regulation of glucocorticoid receptor gamma (GRgamma) by glucocorticoid receptor haplotype and glucocorticoid

scientific article published on September 2004

Regulatory T cells confer a circadian signature on inflammatory arthritis

scientific article published on 03 April 2020

Reply to: Individual Chronotype May Confound with Asthma Symptoms and Therapy

scientific article published on 01 February 2019

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

scientific article published on 26 August 2019

Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients with psoriasis.

scientific article published in December 2005

Restorative sleep predicts the resolution of chronic widespread pain: results from the EPIFUND study

scientific article published on 07 October 2008

Rheumatoid arthritis reprograms circadian output pathways

scientific article published on 06 February 2019

Risk of Incident Diabetes Mellitus Associated With the Dosage and Duration of Oral Glucocorticoid Therapy in Patients With Rheumatoid Arthritis

scientific article published on 14 December 2015

Salivary cortisone is a potential biomarker for serum free cortisol.

scientific article published on 4 August 2010

Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK ⬇️

scientific article

Serum regulates cortisol bioactivity by corticosteroid-binding globulin-dependent and independent mechanisms, as revealed by combined bioassay and physicochemical assay approaches

scientific article published on 01 July 2011

Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions

scientific article published on 18 September 2009

Sleep and cognitive performance: cross-sectional associations in the UK Biobank.

scientific article published on 14 July 2017

Sleep, circadian rhythms, and type 2 diabetes mellitus

scientific article published in 2021

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency

scientific article

Systemic glucocorticoid therapy and adrenal insufficiency in adults: A systematic review

scientific article published on 09 March 2016

T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease

scientific article published on 14 March 2012

The N-terminal transactivation domain of the glucocorticoid receptor mediates apoptosis of human small cell lung cancer cells

scientific article published on 13 August 2014

The Role of Circadian Clock Genes in Critical Illness: The Potential Role of Translational Clock Gene Therapies for Targeting Inflammation, Mitochondrial Function, and Muscle Mass in Intensive Care

scientific article published in 2022

The association between neighbourhood socio-economic status and the onset of chronic widespread pain: results from the EPIFUND study

scientific article published on 07 September 2008

The circadian clock and asthma

scientific article published on 23 May 2013

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

scientific article published in Nature Communications

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

scientific article published on 26 December 2019

The circadian clock regulates inflammatory arthritis.

scientific article published on 3 August 2016

The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.

scientific article

The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis

article

The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

scientific article published on 03 January 2020

The effect of atorvastatin on serum lipoproteins in acromegaly

scientific article published in June 2005

The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus

scientific article

The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer ⬇️

scientific article published on 31 January 2014

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.

scientific article published on 19 December 2011

The role of psychosocial factors in predicting the onset of chronic widespread pain: results from a prospective population-based study

scientific article published on 4 November 2006

The role of the circadian clock in rheumatoid arthritis ⬇️

scientific article published on February 21, 2013

The role of the liver X receptor in chronic obstructive pulmonary disease

scientific article published on 12 October 2013

The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts

scientific article published on 20 March 2018

Thematic reviews

scholarly article by Adrian J L Clark & David W. Ray published June 2011 in Journal of Endocrinology

Thiazolidinediones are partial agonists for the glucocorticoid receptor

scientific article

Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

scientific article published on 29 August 2018

Transverse myelitis as the presentation of Jo-1 antibody syndrome (myositis and fibrosing alveolitis) in long-standing ulcerative colitis.

scientific article published in December 1993

UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation

scientific article

Ultradian cortisol pulsatility encodes a distinct, biologically important signal

scientific article

Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII.

scientific article

VEGF Polymorphisms Are Associated with Severity of Diabetic Retinopathy

scientific article published on 25 April 2008

Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus

scientific article published on March 2016

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