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List of works by Keith W. Kelley

A global view of twenty years of Brain, Behavior, and Immunity

scientific article published on 25 September 2006

A new concept in neurodegeneration: TNFalpha is a silencer of survival signals

scientific article

A newly defined property of somatotropin: priming of macrophages for production of superoxide anion.

scientific article published in February 1988

A novel role of growth hormone and insulin-like growth factor-I. Priming neutrophils for superoxide anion secretion ⬇️

scientific article published on 01 March 1991

Activation of phosphatidylinositol 3'-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes ⬇️

scientific article published on July 15, 1997

Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I ⬇️

scientific article published on 01 February 1998

Activation of the hypothalamic-pituitary-adrenal axis in IL-1 beta-converting enzyme-deficient mice

scientific article published on 01 January 2000

Acute Themal Stressors and Synthesis of Antibodies in Chickens,

scientific article published on 01 May 1980

Advancing the understanding of behaviors associated with Bacille Calmette Guérin infection using multivariate analysis

scientific article published on 7 October 2014

Age-impaired fluid homeostasis depends on the balance of IL-6/IGF-I in the rat supraoptic nuclei

scientific article published on 5 February 2008

Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.

scientific article published on 12 December 2007

Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120

scientific article published on 15 December 2006

Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders

scientific article

Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice.

scientific article published in March 2004

An endogenous 55 kDa TNF receptor mediates cell death in a neural cell line.

scientific article published on June 1996

Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior.

scientific article published on August 1991

Autistic children: a neuroimmune perspective

scientific article published on 16 April 2008

Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice.

scientific article published in July 2005

Behavioral response to fiber feeding is cohort-dependent and associated with gut microbiota composition in mice

article

Brain neocortex modulation of mitogen-induced interleukin 2, but not interleukin 1, production

scientific article

Brain type I but not type II IL-1 receptors mediate the effects of IL-1β on behavior in mice ⬇️

scientific article published on March 1, 1998

C3H/HeJ mice are refractory to lipopolysaccharide in the brain

scientific article published in March 1997

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression

scientific article

Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile

scientific article

Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice

scientific article published in February 1999

Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice.

scientific article

Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures

scientific article

Central and peripheral prostaglandins are involved in sickness behavior in birds

scientific article published in January 1993

Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats.

scientific article published in April 1999

Central interleukin-1 receptors as mediators of sickness.

scientific article published on August 1997

Central lipopolysaccharide elevates plasma IL-6 concentration by an alpha-adrenoreceptor-mediated mechanism ⬇️

scientific article published on June 1, 1997

Central mediation of the effects of interleukin-1 on social exploration and body weight in mice

scientific article published in January 1997

Changes in serum cortisol reveal functional differences in frustration-induced chain chewing in pigs

scientific article published in January 1987

Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice

scientific article

Coincidental changes in behavior and plasma cortisol in unrestrained pigs after intracerebroventricular injection of tumor necrosis factor-alpha

scientific article published on June 1997

Competitive reverse transcriptase-polymerase chain reaction using a synthetic internal RNA standard to quantitate transcripts for leukocyte-derived hormones

scientific article published on 01 January 1994

Conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions

scientific article published in February 1985

Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice.

scientific article published in March 2004

Cyclosporine and alpha-interferon do not attenuate morphine withdrawal in rats but do impair thermoregulation

scientific article published in January 1987

Cytokine-Induced Sickness Behavior and Depression

Cytokines and sickness behavior.

scientific article published in May 1998

Defect in Interleukin-1β Secretion Prevents Sickness Behavior in C3H/HeJ Mice

scientific article published on 01 June 1997

Developmental expression of insulin receptor substrate-2 during dimethylsulfoxide-induced differentiation of human HL-60 cells

scientific article published in January 2000

Dexamethasone up-regulates type II IL-1 receptor in mouse primary activated astrocytes.

scientific article

Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1 ⬇️

scientific article published on October 1, 1992

Differential effect of lipopolysaccharide on food hoarding behavior and food consumption in rats

scientific article

Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats ⬇️

scientific article published on April 17, 1995

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

scientific article published on 30 June 2018

Dose-dependent decrease in mortality with no cognitive or muscle function improvements due to dietary EGCG supplementation in aged mice

scientific article published on 5 January 2017

Dual expression of p80 type I and p68 type II interleukin-I receptors on anterior pituitary cells synthesizing growth hormone

scientific article

Effects of Heat Stress on Rectal Temperature, Respiratory Rate and Activity Rates in Peripartal Sows and Gilts ⬇️

scientific article published on 01 February 1978

Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice.

scientific article

Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat.

scientific article published in February 1992

Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1 beta converting enzyme in the pituitary and brain of mice

scientific article published in August 1996

Effects of lipopolysaccharide on food-motivated behavior in the rat are not blocked by an interleukin-1 receptor antagonist

scientific article published in September 1992

Effects of mannan oligosaccharide on cytokine secretions by porcine alveolar macrophages and serum cytokine concentrations in nursery pigs12

scientific article published on 07 October 2011

Elevated cyclin E levels, inactive retinoblastoma protein, and suppression of the p27(KIP1) inhibitor characterize early development of promyeloid cells into macrophages

scientific article

Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression

scientific article published on 01 July 2000

Energy-expenditure rate of prepartal sows and gilts

scientific article published on 01 December 1978

Energy-expenditure rate of sows and gilts during parturition and lactation

scientific article published on 01 December 1978

Enhancement of coproporphyrinogen III transport into isolated transformed leukocyte mitochondria by ATP.

scientific article published on September 1996

Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10. ⬇️

scientific article published on 18 June 2008

Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

scientific article published on 26 May 2005

Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice

scientific article

Expression of the 75 kDA TNF receptor and its role in contact-mediated neuronal cell death

scientific article published on November 1998

Expression of type I and type II interleukin-1 receptors in mouse brain.

scientific article

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

scientific article

From hormones to immunity: the physiology of immunology

scientific article published in March 2004

From inflammation to sickness and depression: when the immune system subjugates the brain

scientific article

G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.

scientific article

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia

scientific article published on 22 April 2011

Getting nervous about immunity

scientific article published on 18 February 2014

Glial and tissue-specific regulation of Kynurenine Pathway dioxygenases by acute stress of mice.

scientific article published on 12 February 2017

Glutathione augments in vitro proliferative responses of lymphocytes to concanavalin A to a greater degree in old than in young rats

scientific article

Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor ⬇️

scientific article published on February 1, 1992

Growth hormone, growth factors and hematopoiesis

scientific article

Growth hormone, prolactin, and insulin-like growth factors: new jobs for old players

scientific article published on December 1992

Hormonal regulation of the age-associated decline in immune function

scientific article published on 01 January 1987

Hormones, lymphohemopoietic cytokines and the neuroimmune axis.

scientific article published on March 1997

Hypophysectomy Inhibits the Synthesis of Tumor Necrosis Factor α by Rat Macrophages: Partial Restoration by Exogenous Growth Hormone or Interferon γ*

article

IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1 beta-activated mouse primary astrocytes

scientific article published in November 2001

IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase

scientific article

IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts.

scientific article

IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes

scientific article published in April 2005

IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors ⬇️

scientific article published on August 1, 1997

Immunology discovers physiology

scientific article published on October 1994

In Vivo and in Vitro Evidence for the Involvement of Tumor Necrosis Factor-α in the Induction of Leptin by Lipopolysaccharide* ⬇️

scientific article published on 01 May 1998

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain

scientific article

In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates ⬇️

scientific article published on June 1, 1992

In vivo effects of recombinant interferon-gamma: augmentation of endotoxin-induced necrosis of tumors and priming of macrophages for tumor necrosis factor-alpha production

scientific article published on 01 September 1990

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.

scientific article published on 19 August 2012

Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior

scientific journal article

Induction of immunosuppression by dietary aversion acquired in the absence of immunosuppressive treatment

scientific article published in January 1984

Induction of tumor necrosis by delta-aminolevulinic acid and 1,10-phenanthroline photodynamic therapy

scientific article published on 01 January 1996

Influence of stressor predictability and behavioral control on lymphocyte reactivity, antibody responses and neuroendocrine activation in rats

scientific article published in January 1988

Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior.

scientific article

Insulin Growth Factor‐I Inhibits Apoptosis in Hematopoietic: Progenitor Cells Implications in Thymic Aginga ⬇️

scientific article published on May 1, 1998

Insulin activates caspase-3 by a phosphatidylinositol 3'-kinase-dependent pathway

scientific article published on 01 January 1999

Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons

scientific article published on 4 August 2006

Interferon-gamma inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level

scientific article published on March 1995

Interferon-gamma-induced priming for secretion of superoxide anion and tumor necrosis factor-alpha declines in macrophages from aged rats

scientific article published on 01 August 1990

Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice.

scientific article published on May 2013

Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor alpha in mice

scientific article published in December 1991

Interleukin-1 signaling in mouse astrocytes involves Akt: a study with interleukin-4 and IL-10

scientific article published on 01 September 2000

Interleukin-10 in the brain.

scientific article

Interleukin-1beta-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia.

scientific article published in June 1998

Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation: a comparative study.

scientific article

Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression.

scientific article

Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism

scientific article published in September 1995

Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior.

scientific article

Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism

scientific article published on 01 June 1994

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.

scientific article

Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

scientific article

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

scientific article published on September 2010

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

scientific article

Macrophages synthesize and secrete a 25-kilodalton protein that binds insulin-like growth factor-I.

scientific article

Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus

scientific article published on 31 March 2011

Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus

scientific article published on 24 February 2012

Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus.

scientific article published on 27 May 2011

Mechanisms of sickness-induced decreases in food-motivated behavior

scientific article published on January 1996

Mechanisms of the behavioral effects of interleukin 1. Role of prostaglandins and CRF.

scientific article

Mechanisms of the behavioural effects of cytokines.

scientific article

Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice

scientific article published on 11 February 2013

Mice deficient in interleukin-1beta converting enzyme resist anorexia induced by central lipopolysaccharide

scientific article published on 01 November 1999

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

scientific article

Molecular Identification of Two Types of lnterleukin‐1 Receptors in the Murine Pituitary Gland ⬇️

scientific article published on April 1, 1993

Molecular basis of sickness behavior

scientific article

Mouse Moloney leukemia virus infects microglia but not neurons even though it induces motor neuron disease

scientific article published on March 1997

Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts

scientific article published on November 1993

NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice

scientific article published on 19 March 2013

Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?

scientific article

Neuroendocrine-immune interactions

scientific article published on January 1990

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

scientific article

Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice.

scientific article

Phosphatidylinositol 3'-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors.

scientific article published on April 1999

Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats

scientific article published on May 1, 1992

Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide.

scientific article published on 15 July 2004

Protein hormones and immunity

scientific article published on 2 January 2007

RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide

retracted scientific article

Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma

scientific article published in January 2018

Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat.

scientific article published in November 1994

Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone

scientific article published on January 1994

Regulation of myeloid growth and differentiation by the insulin-like growth factor I receptor

scientific article published on January 1997

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.

scientific article published on February 1996

Riboprobe expression cassettes for measuring IGF-I, beta-actin and glyceraldehyde 3-phosphate dehydrogenase transcripts

scientific article published on February 1994

Role of interferon-gamma in counteracting the suppressive effects of transforming growth factor-beta 2 and glucocorticoids on the production of tumor necrosis factor-alpha

scientific article published on December 1990

Sickness behavior as a new target for drug development

scientific article published on January 1, 1992

Sickness behavior in birds caused by peripheral or central injection of endotoxin

scientific article published in February 1993

Somatolactogens, somatomedins, and immunity

scientific article published on August 1993

Somatotropin and prolactin enhance respiratory burst activity of macrophages

scientific article published on 01 January 1988

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.

scientific article published on 23 July 2008

Stress Downregulates Lipopolysaccharide-Induced Expression of Proinflammatory Cytokines in the Spleen, Pituitary, and Brain of Mice

scientific article published on 01 December 1995

Stress and immunity: an integrated view of relationships between the brain and the immune system

scientific article

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

scientific article published on 28 January 2019

Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS

scientific article published on 01 May 1995

Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice.

scientific article published in January 1994

Systemic capsaicin pretreatment fails to block the decrease in food-motivated behavior induced by lipopolysaccharide and interleukin-1beta.

scientific article published in January 1997

Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain.

scientific article

Ten years of Nature Reviews Neuroscience: insights from the highly cited

scientific article

The Importance of Conditioning in Conditioned Immunosuppression ⬇️

scientific article published on April 1, 1988

The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis

scientific article published on March 1995

The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I.

scientific article published in January 1999

The macrophage-activating properties of growth hormone

scientific article published in October 1992

The nucleus basalis is involved in brain modulation of the immune system in rats

scientific article published on May 1990

The pituitary gland is required for protection against lethal effects of Salmonella typhimurium

scientific article published on March 1991

The prognostic landscape of interactive biological processes presents treatment responses in cancer

article

The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior

scientific article

Theoretical and functional aspects of measuring insulin-like growth factor-I mRNA expression in myeloid cells

scientific article published on August 1994

To Boldly Go Where One Has Gone Before.

scientific article published on 14 August 2017

Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis

scientific article published on 16 December 2003

Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferation

scientific article

Tumor necrosis factor(alpha) and insulin-like growth factor-I in the brain: is the whole greater than the sum of its parts?

scientific article

Tumor necrosis factor-alpha induces neuronal death by silencing survival signals generated by the type I insulin-like growth factor receptor.

scientific article

Tumor necrosis factor-alpha-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase

scientific article

Twenty years of research on cytokine-induced sickness behavior

scientific article

Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice.

scientific article

Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally.

scientific article published in June 1996

Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes

scientific article published in November 1996

Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice

scientific article

Voluntary wheel running reverses age-induced changes in hippocampal gene expression

scientific article

[Dissociation between peripheral and central components of tolerance to behavior effects of interleukin-1 in rats]

scientific article published on 01 January 1991

alpha-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice

scientific article published in May 2005

alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.

scientific article published in April 2004

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