List of works - Jochen Walter

&#947;-Secretase, Apolipoprotein E and Cellular Cholesterol Metabolism ⬇️

scientific article published on February 1, 2012

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2

scientific article published on 15 September 2019

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region

scientific article published on 14 December 2020

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.

scientific article published on 5 December 2013

Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.

scientific article published on 21 September 2016

Alzheimer's Disease Associated Presenilin-1 Holoprotein and Its 18−20 kDa C-Terminal Fragment Are Death Substrates for Proteases of the Caspase Family ⬇️

scientific article published on February 24, 1998

BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE) ⬇️

scientific article published on August 26, 2011

Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein

scientific article published on 7 May 2014

Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

scientific article

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model

scientific article published on 20 March 2019

Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

scientific article published on 14 November 2019

Erratum

scholarly article published in Autophagy

Functional Relevance of a Novel SlyX Motif in Non-conventional Secretion of Insulin-degrading Enzyme ⬇️

scientific article published on May 16, 2011

Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).

scientific article

GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells.

scientific article published on 24 May 2014

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein ⬇️

scientific article published on August 27, 2012

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice

scientific article published on 4 July 2015

Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism

scientific article published on 30 April 2020

Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43.

scientific article

Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia

scientific article published on 3 April 2017

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia

scientific article published in June 2015

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease

scientific article published on 17 September 2015

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis

scientific article

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

scientific article published in December 2017

Modified amyloid variants in pathological subgroups of β-amyloidosis

scientific article published on 06 June 2018

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models

scientific article published on 29 July 2020

Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus.

scientific article published on June 2016

Phosphorylation modifies the molecular stability of β-amyloid deposits.

scientific article published on 13 April 2016

Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes ⬇️

scientific article published on January 20, 2012

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

scientific article published on 22 February 2016

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

scientific article

Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

scientific article published on 14 April 2012

Presenilins and γ-Secretase in Membrane Proteostasis

scientific article published on 01 March 2019

Proteolytic Fragments of the Alzheimer's Disease Associated Presenilins-1 and -2 Are Phosphorylated in Vivo by Distinct Cellular Mechanisms ⬇️

scientific article published on April 28, 1998

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

scientific article published on 27 September 2013

Serotonin stimulates secretion of exosomes from microglia cells

scientific article

Sphingolipids: Critical players in Alzheimer’s disease ⬇️

scientific article published on July 23, 2012

Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.

scientific article

Sphingosine-1-phosphate: boon and bane for the brain.

scientific article published on 16 June 2014

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion ⬇️

scientific article published on September 28, 2010

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

scientific article

TREM2 triggers microglial density and age-related neuronal loss

scientific article published on 11 December 2018

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

scientific article published on 22 December 2015

The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2.

scientific article published in August 2016

Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein

scientific article published on 08 March 2016

γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation.

scientific article

List of works by Jochen Walter

&amp;#947;-Secretase, Apolipoprotein E and Cellular Cholesterol Metabolism ⬇️

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.

Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.

Alzheimer's Disease Associated Presenilin-1 Holoprotein and Its 18−20 kDa C-Terminal Fragment Are Death Substrates for Proteases of the Caspase Family ⬇️

BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE) ⬇️

Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein

Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model

Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

Erratum

Functional Relevance of a Novel SlyX Motif in Non-conventional Secretion of Insulin-degrading Enzyme ⬇️

Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).

GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells.

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein ⬇️

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice

Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism

Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43.

Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Modified amyloid variants in pathological subgroups of β-amyloidosis

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models

Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus.

Phosphorylation modifies the molecular stability of β-amyloid deposits.

Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes ⬇️

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

Presenilins and γ-Secretase in Membrane Proteostasis

Proteolytic Fragments of the Alzheimer's Disease Associated Presenilins-1 and -2 Are Phosphorylated in Vivo by Distinct Cellular Mechanisms ⬇️

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

Serotonin stimulates secretion of exosomes from microglia cells

Sphingolipids: Critical players in Alzheimer’s disease ⬇️

Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.

Sphingosine-1-phosphate: boon and bane for the brain.

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion ⬇️

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

TREM2 triggers microglial density and age-related neuronal loss

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2.

Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein

γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation.

γ-Secretase, Apolipoprotein E and Cellular Cholesterol Metabolism ⬇️