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List of works by James C. Iatridis

3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer

scientific article published on 18 August 2018

A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes

scientific article published on 25 July 2006

A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift.

scientific article published on 22 February 2013

AGEs induce ectopic endochondral ossification in intervertebral discs

scientific article

Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape.

scientific article published on 12 January 2017

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration

scientific article published on 11 October 2017

Advanced glycation end products cause RAGE-dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models

scientific article published on 21 September 2020

Advancing basic and preclinical spine research: Highlights from the ORS PSRS 5th International Spine Research Symposium

scientific article published on 02 December 2020

Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging

scientific article published on 01 March 1997

Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.

scientific article

Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies

scientific article published on 14 September 2018

Assessment of compressive modulus, hydraulic permeability and matrix content of trypsin-treated nucleus pulposus using quantitative MRI.

scientific article

Assessment of functional and behavioral changes sensitive to painful disc degeneration

scientific article

Association Between BMP-2 and Carcinogenicity.

scientific article published on 13 August 2015

Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc

scientific journal article

Cellular bone matrices: viable stem cell-containing bone graft substitutes

scientific article

Characterization of an in vitro intervertebral disc organ culture system.

scientific article published on 14 February 2007

Characterization of mechanics and cytocompatibility of fibrin-genipin annulus fibrosus sealant with the addition of cell adhesion molecules

scientific article

Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes

scientific article

Commentary: Does needle injection cause disc degeneration? News in the continuing debate regarding pathophysiology associated with intradiscal injections.

scientific article

Complex loading affects intervertebral disc mechanics and biology

scientific article

Composite biomaterial repair strategy to restore biomechanical function and reduce herniation risk in an ex vivo large animal model of intervertebral disc herniation with varying injury severity

scientific article published on 28 May 2019

Compression-induced changes in intervertebral disc properties in a rat tail model.

scientific article

Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability.

scientific article

Correlating material properties with tissue composition in enzymatically digested bovine annulus fibrosus and nucleus pulposus tissue.

scientific article published on 06 April 2006

Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

scientific article

Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression

scientific article published on 01 June 1998

Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3 ⬇️

scientific article published on May 1, 2013

Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair

scientific article

Determination of collagen-proteoglycan interactions in vitro

scientific article published on 01 June 1996

Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model

scientific article published on 24 April 2014

Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture

scientific article

Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration.

scientific article published on 28 October 2015

Dietary Advanced Glycation End Products have Sex-and Age Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice

scientific article published on 21 November 2017

Dietary advanced glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs

scientific article published on 18 December 2018

Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

scientific article published on 02 October 2019

Different effects of static versus cyclic compressive loading on rat intervertebral disc height and water loss in vitro.

scientific article published on August 2007

Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells?

scientific article published on 18 February 2016

Does type 2 diabetes mellitus promote intervertebral disc degeneration?

scientific article published on 06 June 2016

Dose responsive effects of subcutaneous pentosan polysulfate injection in mucopolysaccharidosis type VI rats and comparison to oral treatment

scientific article

Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo

scientific article published on 20 October 2004

Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development.

scientific article published on January 2013

Effect of mechanical loading on mRNA levels of common endogenous controls in articular chondrocytes and intervertebral disk

scientific article published on 01 June 2005

Effects of Level, Loading Rate, Injury and Repair on Biomechanical Response of Ovine Cervical Intervertebral Discs

scientific article published on 20 June 2018

Effects of enzymatic digestion on compressive properties of rat intervertebral discs.

scientific article

Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo

scientific article published in May 2003

Effects of torsion on intervertebral disc gene expression and biomechanics, using a rat tail model.

scientific article published on April 2011

Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics

scientific article published on 31 May 2018

Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin-treated intervertebral discs under physiological compression loading

scientific article

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug

scientific article

Fibroblast cytoskeletal remodeling contributes to connective tissue tension ⬇️

scientific article published on May 1, 2011

Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study

scientific article published on 25 November 2014

Frequency-dependent behavior of the intervertebral disc in response to each of six degree of freedom dynamic loading: solid phase and fluid phase contributions.

scientific article published on July 2008

Genetic polymorphisms associated with intervertebral disc degeneration.

scientific article published on March 2013

Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs.

scientific article

Homeostasis disrupted by strain mechanosensing

scientific article published on 01 December 2019

Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression.

scientific article published on 29 August 2017

In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair.

scientific article published on 12 November 2016

In vitro organ culture of the bovine intervertebral disc: effects of vertebral endplate and potential for mechanobiology studies.

scientific article

In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression

scientific article published on September 2009

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells.

scientific article

Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model

scientific article published on 21 May 2018

Intervertebral Disk Degeneration and Repair

scientific article published on March 2017

Intervertebral disc cell response to dynamic compression is age and frequency dependent.

scientific article published on June 2009

Is the nucleus pulposus a solid or a fluid? Mechanical behaviors of the nucleus pulposus of the human intervertebral disc.

scientific article published on May 1996

Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state

scientific article published on 17 February 2012

Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

scientific article published on 06 May 2020

Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted ⬇️

scientific article published on April 9, 2012

Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis

scientific article

MSC response to pH levels found in degenerating intervertebral discs

scientific journal article

Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: contributions of matrix fiber orientation and elastin content.

scientific article published on 06 August 2009

Measurements of proteoglycan and water content distribution in human lumbar intervertebral discs.

scientific article

Measuring the neutral zone of spinal motion segments: Comparison of multiple analysis methods to quantify spinal instability

scientific article published on 25 April 2020

Mechanical conditions that accelerate intervertebral disc degeneration: overload versus immobilization.

scientific article

Mechanical damage to the intervertebral disc annulus fibrosus subjected to tensile loading

scientific article published in March 2005

Mechanical homeostasis is altered in uterine leiomyoma

scientific article published on April 2008

Mechanical modulation of growth for the correction of vertebral wedge deformities

scientific article published on 01 July 1999

Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair

scientific article published on 11 November 2015

Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus.

scientific article published in August 2004

Molecular mechanisms of biological aging in intervertebral discs

scientific article

Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model

scientific article published on 21 December 2019

Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model

scientific article published on February 2008

Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently.

scientific article

Neonatal annulus fibrosus regeneration occurs via recruitment and proliferation of Scleraxis-lineage cells

scientific article published on 20 December 2019

New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain.

scientific article published on August 2016

New horizons in spine research: Intervertebral disc repair and regeneration

scientific article published in January 2017

Nonoperative management of discogenic back pain: a systematic review.

scientific article

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells.

scientific article published on 31 May 2011

Outcomes and complications of diabetes mellitus on patients undergoing degenerative lumbar spine surgery

scientific article

Penetrating Annulus Fibrosus Injuries Affect Dynamic Compressive Behaviors of the Intervertebral Disc Via Altered Fluid Flow: An Analytical Interpretation ⬇️

scientific article published on August 1, 2011

Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses

scientific article (publication date: 2013)

Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine

scientific article published on 23 March 2018

Quantitative MRI as a diagnostic tool of intervertebral disc matrix composition and integrity.

scientific article published on 13 November 2008

Refinement of elastic, poroelastic, and osmotic tissue properties of intervertebral disks to analyze behavior in compression.

scientific article published on 14 August 2010

Regenerative potential of TGFβ3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells ⬇️

scientific article published on August 22, 2011

Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?

scientific article published on 29 January 2013

Role of endplates in contributing to compression behaviors of motion segments and intervertebral discs.

scientific article published on 19 January 2006

Shear mechanical properties of human lumbar annulus fibrosus

scientific article published in September 1999

Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines

scientific article

Spatial mapping of collagen content and structure in human intervertebral disk degeneration

scientific article published on 02 November 2020

Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration

scientific article published on 01 November 1999

Stress and matrix-responsive cytoskeletal remodeling in fibroblasts.

scientific article

Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks

scientific article published on 2 May 2017

Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome) ⬇️

scientific article published on November 28, 2012

TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs

scientific article published on 3 March 2015

Tensile properties of nondegenerate human lumbar anulus fibrosus

scientific article published on 01 February 1996

The Importance of Diversity, Equity and Inclusion in Orthopaedic Research

scientific article published on 08 April 2020

The effects of needle puncture injury on microscale shear strain in the intervertebral disc annulus fibrosus

scientific article

The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc.

scientific article published on 9 April 2005

The impact of diabetes mellitus on patients undergoing degenerative cervical spine surgery

scientific article

The viscoelastic behavior of the non-degenerate human lumbar nucleus pulposus in shear

scientific article published on 01 October 1997

Tissue engineering: Function follows form.

scientific article published on December 2009

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