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List of works by Anthony Segal

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

scientific article published on July 2016

A phagocyte dilemma.. ⬇️

scientific article published on March 1, 2011

A rapid single centrifugation step method for the separation of erythrocytes, granulocytes and mononuclear cells on continous density gradients of percoll

scientific article published on 01 January 1980

Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease

scientific article published on 01 January 1980

Activation of the Neutrophil NADPH Oxidase Is Inhibited by SB 203580, a Specific Inhibitor of SAPK2/p38

scientific article published on 01 June 1999

Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity

scientific article (publication date: 2015)

An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils

scientific article published on 28 February 2017

An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum

scientific article published on November 2006

Biochemistry and molecular biology of chronic granulomatous disease.

scientific article published in January 1992

CO binding and ligand discrimination in human myeloperoxidase

scientific article published on March 2010

Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease

scientific article

Characterisation of the enzyme defect in chronic granulomatous disease ⬇️

scientific article published on June 26, 1976

Characterization of expression quantitative trait loci in the human colon

scientific article published on February 2015

Chronic granulomatous disease

scientific article published on 01 October 1994

Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency

scientific article

Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.

scientific article published on 10 March 2015

Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

correction of a scientific article; published on 30 May 2019

Corrigendum: An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.

scientific article published on 11 October 2017

Crohn's disease as an immunodeficiency

scientific article published in July 2010

Crohn's disease: an immune deficiency state

scientific article

Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)

scientific article

Defective acute inflammation in Crohn's disease: a clinical investigation

scientific article

Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci

scientific article

Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility

scientific article published in March 1997

Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4.

scientific article

Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease

scientific article

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

scientific article published on 03 August 2009

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

scientific article

Effects of microinjected small GTPases on the actin cytoskeleton of human neutrophils

scientific article published on 01 October 2003

Elastase in the different primary granules of the human neutrophil

scientific article published on 01 November 1985

Evidence that neutrophil elastase-deficient mice are resistant to bleomycin-induced fibrosis

scientific article published in July 2001

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction

scientific article

Gene transfer to primary chronic granulomatous disease monocytes

scientific article published in July 1995

Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families

scientific article

Halothane does not inhibit human neutrophil function in vitro

scientific article published in December 1979

How neutrophils kill microbes

scientific article

Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator.

scientific article published on 5 April 2017

Impaired macrophage function following bacterial stimulation in chronic granulomatous disease

scientific article published in October 2009

Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor.

scientific article published on August 2006

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

scientific article

Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease

scientific article

Innate immunity in inflammatory bowel disease: a disease hypothesis

scientific article

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

preprint published 25 September 2016

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

scientific article

Intramembrane Bis-Heme Motif for Transmembrane Electron Transport Conserved in a Yeast Iron Reductase and the Human NADPH Oxidase

scientific article published in Journal of Biological Chemistry

Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils

scientific article published in April 2002

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

scientific article

Kinetics of oxygen consumption by phagocytosing human neutrophils

scientific article published on 01 October 1978

Levamisole in the treatment of Crohn's disease ⬇️

scientific article published on August 20, 1977

Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils

scientific article published in August 2003

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition

scientific article published on 19 June 2012

Making sense of the cause of Crohn's - a new look at an old disease

scientific article published on 12 October 2016

Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis

scientific article published on January 2007

Modified skin window technique for the extended characterisation of acute inflammation in humans

scientific article published in April 2007

Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis

scientific article

N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates

scientific article

NADPH Oxidase Is Not Essential for Low-Density Lipoprotein Oxidation by Human Monocyte-Derived Macrophages

scientific article published on 01 August 1994

NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humans

scientific article

NEUTROPHIL CYTOCHROME b IN CHRONIC GRANULOMATOUS DISEASE

scientific article published in The Lancet

NITROBLUE-TETRAZOLIUM TESTS

scientific article published in The Lancet

Neutrophil dysfunction in Crohn's disease ⬇️

scientific article published on July 31, 1976

Nitroblue tetrazolium — A new lipoprotein stain

scientific article published on 01 November 1973

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

scientific article published on 4 June 2015

PRELIMINARY EVIDENCE FOR GUT INVOLVEMENT IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS?

article

PX domain takes shape

scientific article

Phagocyte dysfunction and inflammatory bowel disease

scientific article published on October 2008

Phenotypic heterogeneity and evidence of a founder effect associated with G6PC3 mutations in patients with severe congenital neutropenia

scientific article

Phosphorylation of p67 phox in the neutrophil occurs in the cytosol and is independent of p47 phox

scientific article published on 01 April 1999

Production of superoxide by neutrophils: a reappraisal ⬇️

scientific article published on April 1, 1979

RE-EVALUATION OF NITROBLUE- TETRAZOLIUM TEST

scientific article published in The Lancet

Rapid incorporation of the human neutrophil plasma membrane cytochrome b into phagocytic vacuoles

scientific article published on 01 January 1980

Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte

scientific article published in August 2003

Reconstitution of GTPγS-Induced NADPH Oxidase Activity in Streptolysin-O-Permeabilized Neutrophils by Specific Cytosol Fractions

scientific article published on 01 November 1999

Reconstitution of cell-free NADPH oxidase activity by purified components

scientific article

Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate ⬇️

scientific article published on May 14, 1979

SIGNAL TRANSDUCTION:Signals to Move Cells

scientific article

Shotgun cholanomics of ileal fluid

scientific article published on 14 September 2012

Studies on patients establish Crohn's disease as a manifestation of impaired innate immunity

scientific article published on 27 June 2019

Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin

scientific article published on 15 July 2010

Subproteome analysis of the neutrophil cytoskeleton

scientific article published on April 2009

The FRE1 Ferric Reductase ofSaccharomyces cerevisiaeIs a CytochromebSimilar to That of NADPH Oxidase

scientific article published in Journal of Biological Chemistry

The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

scientific article published on 12 May 2017

The NADPH Oxidase Components p47phox and p40phox Bind to Moesin through Their PX Domain ⬇️

scientific article (publication date: 30 November 2001)

The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole

scientific article

The NADPH oxidase of phagocytic leukocytes

scientific article

The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems

scientific article published in June 2004

The antimicrobial role of the neutrophil leukocyte.

scientific article published on March 1981

The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts

scientific article published on 01 October 1988

The biochemical basis of the NADPH oxidase of phagocytes.

scientific article

The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals

scientific article published on 09 October 2007

The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs.

scientific article published on November 2007

The immunopathogenesis of Crohn's disease: a three-stage model

scientific article published on 08 August 2009

The kinetic measurement of phagocyte function in whole blood

scientific article published on 01 May 1983

The large-conductance Ca2+-activated K+ channel is essential for innate immunity

scientific article

The major phosphorylation site of the NADPH oxidase component p67phox is Thr233.

scientific article published on February 1999

The management of chronic granulomatous disease

scientific article published on 01 November 1993

The neutrophil respiratory burst and bacterial digestion in Crohn's disease

scientific article

The production of hydroxyl and superoxide radicals by stimulated human neutrophils - measurements by EPR spectroscopy ⬇️

scientific article published on April 1, 1979

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

scientific article published in Nature

The role of grancalcin in adhesion of neutrophils

scientific article published on 01 April 2006

The role of neutrophils in the pathogenesis of Crohn's disease

scientific article published on 01 November 2018

The use of nitroblue tetrazolium prestaining of serum lipoproteins on polyacrylamide disc electrophoresis

scientific article published on 01 June 1974

The α subunit of cytochrome b−245 mapped to chromosome 16

scientific article published on 01 November 1990

Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10

article

VARIATIONS ON THE THEME OF CHRONIC GRANULOMATOUS DISEASE

scientific article published in The Lancet

What is wrong with granulocytes in inflammatory bowel diseases?

scientific article

Ym1 Is a Neutrophil Granule Protein That Crystallizes in p47 -deficient Mice ⬇️

scientific article published on December 3, 2001

ZODET: software for the identification, analysis and visualisation of outlier genes in microarray expression data

scientific article

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