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List of works by Merrie Mosedale

A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis

scientific article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

scientific article published on 21 September 2016

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

scientific article published in PLoS ONE

Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine

scientific article published on 01 August 2018

Drug-induced liver injury: Advances in mechanistic understanding that will inform risk management

scientific article

Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug

scientific article published on 23 June 2014

Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach

scientific article published on 23 January 2017

Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion

scientific journal article

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury

scientific article published on 01 August 2019

Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach

scientific article published on 01 December 2019

Mechanisms of Drug-induced Liver Injury

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

scientific article published on January 2008

Mouse Population-Based Approaches to Investigate Adverse Drug Reactions

scientific article published on 25 July 2018

Neurexin-1α contributes to insulin-containing secretory granule docking

scientific journal article

Optimized Methods to Explore the Mechanistic and Biomarker Potential of Hepatocyte-Derived Exosomes in Drug-Induced Liver Injury

scientific article published on 27 January 2018

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

scientific article published on 21 November 2012

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-induced Liver Injury

scholarly article by Diane M Longo et al published 5 October 2018 in Toxicological Sciences

Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials

scientific article

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

scientific article

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

scientific article published on 08 March 2016

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury

scientific article published on 21 October 2020

Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).

scientific article

Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury

scientific article published on 21 February 2020

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

scientific article

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