List of works - Hanne Frederiksen

2-Amino-1-methyl-6-(5-hydroxy-)phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

scientific article

A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months

scientific article

A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging

scientific article published on 06 August 2018

Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

scientific article published on 01 March 2019

Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme

scientific article published on 02 October 2018

Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing

scientific article published on 18 July 2019

Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.

scientific article published on 03 January 2014

Assumed non-persistent environmental chemicals in human adipose tissue; matrix stability and correlation with levels measured in urine and serum

scientific article published on 22 March 2017

Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

scientific article

Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial.

scientific article published on February 2006

Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS.

scientific article published on 13 March 2013

Bisphenol A, phthalate metabolites and glucose homeostasis in healthy, normal-weight children.

scientific article published on 13 December 2017

Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009-2017

scientific article published on 25 October 2019

Characterization of Human Adrenal Steroidogenesis During Fetal Development

scientific article published on 01 May 2019

Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth

scientific article

Clinical proteomics: Insights from IGF-I.

scientific article published on 28 November 2017

Considerations for estimating daily intake values of nonpersistent environmental endocrine disruptors based on urinary biomonitoring data

scientific article

Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry

scientific article published on September 2010

Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach

scientific article published on 9 February 2012

Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols.

scientific article published on 2 March 2014

Dermal Uptake of Benzophenone-3 from Clothing.

scientific article published on 31 August 2017

Development and Interlaboratory Validation of Two Fast UPLC-MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates

scientific article published on 01 July 2019

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum

article

Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease

scientific article

Dietary supplementation with an extract of lycopene-rich tomatoes does not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits

scientific article published on 01 January 2007

Direct action of endocrine disrupting chemicals on human sperm

scientific article

Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain.

scientific article published on 13 September 2017

Do parabens have the ability to interfere with steroidogenesis?

scientific article

Effect of valine 106 on structure-function relation of cytosolic human thymidine kinase. Kinetic properties and oligomerization pattern of nine substitution mutants of V106.

scientific article

Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits

scientific article published in May 2007

Endocrine disrupters: we need research, biomonitoring and action

scientific article published on 11 July 2016

Endocrine disruptors in seminal fluid: bisphenol A, triclosan and benzophenone-3

Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence.

scientific article published on 25 July 2012

Endocrine potency of wastewater: contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

scientific article published on February 2011

Environmental phenols and parabens in adipose tissue from hospitalized adults in Southern Spain

scientific article published on 04 July 2018

Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

scientific article published on 19 November 2020

Estimated daily intake and hazard quotients and indices of phthtalate diesters for young danish men.

scientific article published on 10 December 2013

Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AalphaC).

scientific article published on June 2004

Exposure to UV filters during summer and winter in Danish kindergarten children

scientific article published on 16 November 2016

Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population.

scientific article published on 16 May 2017

Germ Cell Neoplasia in Situ and Preserved Fertility Despite Suppressed Gonadotropins in a Patient With Testotoxicosis

scientific article

High urinary phthalate concentration associated with delayed pubarche in girls

scientific article published on 19 March 2012

Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration

scientific article

Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012.

scientific article

Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty

scientific article

Identification of metabolites in urine and feces from rats dosed with the heterocyclic amine, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C).

scientific article

Impact of five cytochrome p450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC).

scientific article published in May 2003

Improved synthesis methods of standards used for quantitative determination of total isothiocyanates from broccoli in human urine

scientific article published on 26 January 2007

In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (A(alpha)C) and 2-amino-3-methyl-9H-pyridol2,3-b]indole (MeA(alpha)C) in human and rat hepatic microsomes

scientific article

Influence of phthalates on cytokine production in monocytes and macrophages: a systematic review of experimental trials

scientific article

Influence of phthalates on in vitro innate and adaptive immune responses

scientific article published on 25 June 2015

Isotope-dilution TurboFlow-LC-MS/MS method for simultaneous quantification of ten steroid metabolites in serum

scientific article

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

scientific article

Longitudinal Changes in Circulating Testosterone Levels Determined by LC-MS/MS and by a Commercially Available Radioimmunoassay in Healthy Girls and Boys during the Pubertal Transition

Longitudinal changes in serum concentrations of adrenal androgen metabolites and their ratios by LC-MS/MS in healthy boys and girls

scientific article published on 21 September 2015

Many putative endocrine disruptors inhibit prostaglandin synthesis

scientific article

Maternal exposure to UV filters: associations with maternal thyroid hormones, IGF-I/IGFBP3 and birth outcomes

scientific article published on 23 January 2018

Metabolism of phthalates in humans

scientific article

Migration of phthalates on culture plates - an important challenge to consider for in vitro studies.

scientific article published on 12 January 2016

Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

scientific article published on 01 November 2018

Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

scientific article published on 10 March 2010

Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men

scientific article

Phthalates Are Metabolised by Primary Thyroid Cell Cultures but Have Limited Influence on Selected Thyroid Cell Functions In Vitro

scientific article

Prenatal Exposure to Phthalates and Anogenital Distance in Male Infants from a Low-Exposed Danish Cohort (2010-2012).

scientific article published on 15 December 2015

Prenatal Triclosan Exposure and Anthropometric Measures Including Anogenital Distance in Danish Infants

scientific article

Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort

article

Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort

scientific article published on 30 November 2017

Presence of benzophenones commonly used as UV filters and absorbers in paired maternal and fetal samples

scientific article

SUN-039 Characterization of Human Adrenal Steroidogenesis during Fetal Development.

scientific article published on 30 April 2019

Serum Phthalate and Triclosan Levels Have Opposing Associations With Risk Factors for Gestational Diabetes Mellitus

scientific article published on 13 March 2018

Serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in children determined by TurboFlow-LC-MS/MS.

scientific article published on 20 February 2013

Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults

article

Sex-specific Estrogen Levels and Reference Intervals from Infancy to Late Adulthood Determined by LC-MS/MS

scientific article published on 01 March 2020

Special issue on the Impact of endocrine disrupters on reproductive health

scientific article published on 4 March 2014

Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters

scientific article published on June 2012

Syntheses of DNA adducts of two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and identification of DNA adducts in organs from rats dosed with MeAalphaC.

scientific article published in April 2004

Temporal Variability in Urinary Phthalate Metabolite Excretion Based on Spot, Morning, and 24-h Urine Samples: Considerations for Epidemiological Studies

article

Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples

The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements.

scientific article published on 14 October 2014

The European COPHES/DEMOCOPHES project: towards transnational comparability and reliability of human biomonitoring results

scientific article

The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age.

scientific article

The association between phthalate exposure and atopic dermatitis with a discussion of phthalate induced secretion of interleukin-1β and thymic stromal lymphopoietin.

scientific article published on 19 February 2016

The influence of antenatal exposure to phthalates on subsequent female reproductive development in adolescence: a pilot study

scientific article published on 2 March 2014

Two food-borne heterocyclic amines: metabolism and DNA adduct formation of amino-alpha-carbolines

scientific article

UV filters analyzed by isotope diluted TurboFlow-LC-MS/MS in urine from Danish children and adolescents

scientific article published in September 2016

UV filters in matched seminal fluid-, urine-, and serum samples from young men

scientific article published on 12 February 2020

Urinary BPA measurements in children and mothers from six European member states: Overall results and determinants of exposure.

scientific article published on 13 October 2014

Urinary Phthalates From 168 Girls and Boys Measured Twice a Year During a 5-Year Period: Associations With Adrenal Androgen Levels and Puberty

article by A. Mouritsen et al published September 2013 in The Journal of Clinical Endocrinology and Metabolism

Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality

scientific article

Urinary excretion of phenols, parabens and benzophenones in young men: Associations to reproductive hormones and semen quality are modified by mutations in the Filaggrin gene

scientific article published on 20 September 2018

Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake

scientific article published on 22 March 2011

Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs

scientific article

Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans

scientific article

Urinary excretion of total isothiocyanates from cruciferous vegetables shows high dose–response relationship and may be a useful biomarker for isothiocyanate exposure

scientific article published on 23 August 2007

Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia

scientific article published in June 2012

Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy

scientific article published on 14 December 2018

List of works by Hanne Frederiksen

2-Amino-1-methyl-6-(5-hydroxy-)phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months

A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging

Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

Analyzing terephthalate metabolites in human urine as biomarkers of exposure: Importance of selection of metabolites and deconjugation enzyme

Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing

Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.

Assumed non-persistent environmental chemicals in human adipose tissue; matrix stability and correlation with levels measured in urine and serum

Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes

Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial.

Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS.

Bisphenol A, phthalate metabolites and glucose homeostasis in healthy, normal-weight children.

Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009-2017

Characterization of Human Adrenal Steroidogenesis During Fetal Development

Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth

Clinical proteomics: Insights from IGF-I.

Considerations for estimating daily intake values of nonpersistent environmental endocrine disruptors based on urinary biomonitoring data

Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry

Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach

Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols.

Dermal Uptake of Benzophenone-3 from Clothing.

Development and Interlaboratory Validation of Two Fast UPLC-MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum

Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease

Dietary supplementation with an extract of lycopene-rich tomatoes does not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits

Direct action of endocrine disrupting chemicals on human sperm

Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain.

Do parabens have the ability to interfere with steroidogenesis?

Effect of valine 106 on structure-function relation of cytosolic human thymidine kinase. Kinetic properties and oligomerization pattern of nine substitution mutants of V106.

Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits

Endocrine disrupters: we need research, biomonitoring and action

Endocrine disruptors in seminal fluid: bisphenol A, triclosan and benzophenone-3

Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence.

Endocrine potency of wastewater: contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

Environmental phenols and parabens in adipose tissue from hospitalized adults in Southern Spain

Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

Estimated daily intake and hazard quotients and indices of phthtalate diesters for young danish men.

Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AalphaC).

Exposure to UV filters during summer and winter in Danish kindergarten children

Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population.

Germ Cell Neoplasia in Situ and Preserved Fertility Despite Suppressed Gonadotropins in a Patient With Testotoxicosis

High urinary phthalate concentration associated with delayed pubarche in girls

Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration

Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012.

Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty

Identification of metabolites in urine and feces from rats dosed with the heterocyclic amine, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C).

Impact of five cytochrome p450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC).

Improved synthesis methods of standards used for quantitative determination of total isothiocyanates from broccoli in human urine

In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (A(alpha)C) and 2-amino-3-methyl-9H-pyridol2,3-b]indole (MeA(alpha)C) in human and rat hepatic microsomes

Influence of phthalates on cytokine production in monocytes and macrophages: a systematic review of experimental trials

Influence of phthalates on in vitro innate and adaptive immune responses

Isotope-dilution TurboFlow-LC-MS/MS method for simultaneous quantification of ten steroid metabolites in serum

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

Longitudinal Changes in Circulating Testosterone Levels Determined by LC-MS/MS and by a Commercially Available Radioimmunoassay in Healthy Girls and Boys during the Pubertal Transition

Longitudinal changes in serum concentrations of adrenal androgen metabolites and their ratios by LC-MS/MS in healthy boys and girls

Many putative endocrine disruptors inhibit prostaglandin synthesis

Maternal exposure to UV filters: associations with maternal thyroid hormones, IGF-I/IGFBP3 and birth outcomes

Metabolism of phthalates in humans

Migration of phthalates on culture plates - an important challenge to consider for in vitro studies.

Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men

Phthalates Are Metabolised by Primary Thyroid Cell Cultures but Have Limited Influence on Selected Thyroid Cell Functions In Vitro

Prenatal Exposure to Phthalates and Anogenital Distance in Male Infants from a Low-Exposed Danish Cohort (2010-2012).

Prenatal Triclosan Exposure and Anthropometric Measures Including Anogenital Distance in Danish Infants

Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort

Prenatal phthalate exposure and language development in toddlers from the Odense Child Cohort

Presence of benzophenones commonly used as UV filters and absorbers in paired maternal and fetal samples

SUN-039 Characterization of Human Adrenal Steroidogenesis during Fetal Development.

Serum Phthalate and Triclosan Levels Have Opposing Associations With Risk Factors for Gestational Diabetes Mellitus

Serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in children determined by TurboFlow-LC-MS/MS.

Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults

Sex-specific Estrogen Levels and Reference Intervals from Infancy to Late Adulthood Determined by LC-MS/MS

Special issue on the Impact of endocrine disrupters on reproductive health

Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters

Syntheses of DNA adducts of two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and 2-amino-9H-pyrido[2,3-b]indole (AalphaC) and identification of DNA adducts in organs from rats dosed with MeAalphaC.

Temporal Variability in Urinary Phthalate Metabolite Excretion Based on Spot, Morning, and 24-h Urine Samples: Considerations for Epidemiological Studies

Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples

The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements.