List of works - Alex C Manhães

A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice

scientific article published on 7 June 2016

Adipocyte morphology and leptin signaling in rat offspring from mothers supplemented with flaxseed during lactation

scientific article

Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolescent C57BL/6 mice.

scientific article published on 3 June 2008

Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning.

scientific article published on 15 November 2013

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

scientific article

Attentional performance may help to identify duloxetine responders in chronic pain fibromyalgia patients.

scientific article

Beta-adrenergic receptor activation increases GABA uptake in adolescent mice frontal cortex: Modulation by cannabinoid receptor agonist WIN55,212-2

scientific article published on 29 August 2018

Calcium reduces vitamin D and glucocorticoid receptors in the visceral fat of obese male rats.

scientific article published on 20 June 2016

Calcium supplementation reverts central adiposity, leptin, and insulin resistance in adult offspring programed by neonatal nicotine exposure.

scientific article

Callosal agenesis affects consistency of laterality in a paw preference task in BALB/cCF mice

scientific article published on 10 November 2004

Cigarette smoke during lactation in rat female progeny: Late effects on endocannabinoid and dopaminergic systems

scientific article published on 15 June 2019

Combined exposure to nicotine and ethanol in adolescent mice differentially affects anxiety levels during exposure, short-term, and long-term withdrawal.

scientific article

Combined exposure to nicotine and ethanol in adolescent mice differentially affects memory and learning during exposure and withdrawal

scientific article

Combined exposure to nicotine and ethanol in adolescent mice: effects on the central cholinergic systems during short and long term withdrawal.

scientific article published on 22 May 2009

Combined exposure to tobacco smoke and ethanol during adolescence leads to short- and long-term modulation of anxiety-like behavior

scientific article published on 27 June 2013

Combined exposure to tobacco smoke and ethanol in adolescent mice elicits memory and learning deficits both during exposure and withdrawal

scientific article

Concurrent maternal and pup postnatal tobacco smoke exposure in Wistar rats changes food preference and dopaminergic reward system parameters in the adult male offspring

scientific article published on 7 June 2015

Developmental alcohol exposure leads to a persistent change on astrocyte secretome.

scientific article

Developmental plasticity in adrenal function and leptin production primed by nicotine exposure during lactation: gender differences in rats.

scientific article

Dietary calcium supplementation in adult rats reverts brown adipose tissue dysfunction programmed by postnatal early overfeeding

scientific article published on 11 October 2016

Early callosal absence disrupts the establishment of normal neocortical structure in Swiss mice

scientific article published on 19 January 2006

Early weaning by maternal prolactin inhibition leads to higher neuropeptide Y and astrogliosis in the hypothalamus of the adult rat offspring

scientific article published on 22 January 2015

Early weaning is associated with higher neuropeptide Y (NPY) and lower cocaine- and amphetamine-regulated transcript (CART) expressions in the paraventricular nucleus (PVN) in adulthood.

scientific article published on 5 July 2012

Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation

scientific article

Effects of callosal agenesis on rotational side preference of BALB/cCF mice in the free swimming test

scientific article published on 01 November 2004

Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats

scientific article published on 19 May 2017

Effects of early and late neonatal bromocriptine treatment on hypothalamic neuropeptides, dopaminergic reward system and behavior of adult rats.

scientific article published on 30 March 2016

Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring

scientific article published on 23 December 2018

Effects of maternal hyperleptinaemia during lactation on short-term memory/learning, anxiety-like and novelty-seeking behavioral traits of adult male rats.

scientific article

Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny

scientific article published on 04 February 2015

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

scientific article published on 24 May 2016

Energy drink enhances the behavioral effects of alcohol in adolescent mice.

scientific article published on 26 April 2017

Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain.

scientific article published on 19 August 2011

Exposure to methamidophos at adulthood elicits depressive-like behavior in mice.

scientific article published on 7 February 2009

Exposure to nicotine and ethanol in adolescent mice: effects on depressive-like behavior during exposure and withdrawal

scientific article published on 21 March 2011

Exposure to nicotine increases dopamine receptor content in the mesocorticolimbic pathway of rat dams and offspring during lactation.

scientific article published on 25 July 2015

Exposure to tobacco smoke containing either high or low levels of nicotine during adolescence: differential effects on choline uptake in the cerebral cortex and hippocampus

scientific article published on 10 May 2010

GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.

scientific article published on 6 June 2015

Hippocampal increased cell death and decreased cell density elicited by nicotine and/or ethanol during adolescence are reversed during drug withdrawal.

scientific article published on 4 February 2010

Hyperactivity and memory/learning deficits evoked by developmental exposure to nicotine and/or ethanol are mitigated by cAMP and cGMP signaling cascades activation.

scientific article published on 10 April 2018

Hypothalamic Neuropeptides Expression and Hypothalamic Inflammation in Adult Rats that Were Exposed to Tobacco Smoke during Breastfeeding: Sex-Related Differences

scientific article published on 02 September 2019

Increased lateralization in rotational side preference in male mice rendered acallosal by prenatal gamma irradiation

scientific article published on 26 April 2005

Individual differences in novelty-seeking behavior but not in anxiety response to a new environment can predict nicotine consumption in adolescent C57BL/6 mice.

scientific article

Locomotor response to acute nicotine in adolescent mice is altered by maternal undernutrition during lactation

scientific article

Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.

scientific article published on 28 October 2015

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring.

scientific article published on 3 June 2015

Maternal nicotine exposure during lactation alters hypothalamic neuropeptides expression in the adult rat progeny.

scientific article published on 24 April 2013

Maternal prolactin inhibition at the end of lactation affects learning/memory and anxiety-like behaviors but not novelty-seeking in adult rat progeny.

scientific article published on 18 July 2011

Maternal protein-free diet during lactation programs male Wistar rat offspring for increased novelty-seeking, locomotor activity, and visuospatial performance.

scientific article

Maternal undernutrition during lactation alters nicotine reward and DOPAC/dopamine ratio in cerebral cortex in adolescent mice, but does not affect nicotine-induced nAChRs upregulation.

scientific article

Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior.

scientific article published on 17 April 2013

Neonatal Nicotine Exposure Leads to Hypothalamic Gliosis in Adult Overweight Rats.

scientific article published on 10 October 2015

Neonatal hyperleptinaemia programmes anxiety-like and novelty seeking behaviours but not memory/learning in adult rats.

scientific article

Neonatal phencyclidine as a model of sex-biased schizophrenia symptomatology in adolescent mice

scientific article published in 2023

Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats.

scientific article

Neonatal transection of the corpus callosum affects paw preference lateralization of adult Swiss mice.

scientific article published in September 2003

Neonatal transection of the corpus callosum affects rotational side preference in adult Swiss mice.

scientific article published on 10 January 2007

Nicotine and ethanol interact during adolescence: effects on the central cholinergic systems

scientific article published on 28 July 2008

Ontogenetic analysis of behavior in the tail suspension test: temporal differences in the emergence of within- and between-session habituation in Swiss mice.

scientific article

Prenatal Systemic Hypoxia-Ischemia and Oligodendroglia Loss in Cerebellum.

scientific article

Prenatal hypoxic-ischemic insult changes the distribution and number of NADPH-diaphorase cells in the cerebellum

scientific article

Sex differences in the incidence of total callosal agenesis in BALB/cCF mice.

scientific article published in June 2002

Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats

scientific article published on 09 April 2019

Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolescent Mice Frontal Cortex

scientific article published on 21 July 2020

Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms.

scientific article

The effect of D-serine administration on cognition and mood in older adults

scientific article published on 24 February 2016

The effect of corpus callosum agenesis on neocortical thickness and neuronal density of BALB/cCF mice.

scientific article

The effects of total and partial callosal agenesis on the development of paw preference performance in the BALB/cCF mouse

scientific article

Thyroid hormone deficiency changes the distribution of oligodendrocyte/myelin markers during oligodendroglial differentiation in vitro

scientific article published on 09 October 2006

Tobacco and alcohol use during adolescence: Interactive mechanisms in animal models.

scientific article

Tobacco smoke and ethanol during adolescence: Both combined- and single-drug exposures lead to short- and long-term disruption of the serotonergic system in the mouse brain

scientific article published on 22 December 2018

Tobacco smoke containing high or low levels of nicotine during adolescence: effects on novelty-seeking and anxiety-like behaviors in mice

scientific article published on 18 November 2014

Ultrastructural identification of oligodendrocyte/myelin proteins in corpus callosum of hypothyroid animals.

scientific article published on 7 January 2007

Undernutrition during early life alters neuropeptide Y distribution along the arcuate/paraventricular pathway.

scientific article published on 30 October 2013

Unilateral hemispherectomy at adulthood asymmetrically affects immobile behavior of male Swiss mice.

scientific article

Unilateral hemispherectomy at adulthood asymmetrically affects motor performance of male Swiss mice.

scientific article published on 25 February 2012

Value of combining activated brain FDG-PET and cardiac MIBG for the differential diagnosis of dementia: differentiation of dementia with Lewy bodies and Alzheimer disease when the diagnoses based on clinical and neuroimaging criteria are difficult.

scientific article published in June 2008

Visual defects in a mouse model of fetal alcohol spectrum disorder.

scientific article

List of works by Alex C Manhães

A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice

Adipocyte morphology and leptin signaling in rat offspring from mothers supplemented with flaxseed during lactation

Anxiety-like behavior during nicotine withdrawal predict subsequent nicotine consumption in adolescent C57BL/6 mice.

Anxiety-like, novelty-seeking and memory/learning behavioral traits in male Wistar rats submitted to early weaning.

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

Attentional performance may help to identify duloxetine responders in chronic pain fibromyalgia patients.

Beta-adrenergic receptor activation increases GABA uptake in adolescent mice frontal cortex: Modulation by cannabinoid receptor agonist WIN55,212-2

Calcium reduces vitamin D and glucocorticoid receptors in the visceral fat of obese male rats.

Calcium supplementation reverts central adiposity, leptin, and insulin resistance in adult offspring programed by neonatal nicotine exposure.

Callosal agenesis affects consistency of laterality in a paw preference task in BALB/cCF mice

Cigarette smoke during lactation in rat female progeny: Late effects on endocannabinoid and dopaminergic systems

Combined exposure to nicotine and ethanol in adolescent mice differentially affects anxiety levels during exposure, short-term, and long-term withdrawal.

Combined exposure to nicotine and ethanol in adolescent mice differentially affects memory and learning during exposure and withdrawal

Combined exposure to nicotine and ethanol in adolescent mice: effects on the central cholinergic systems during short and long term withdrawal.

Combined exposure to tobacco smoke and ethanol during adolescence leads to short- and long-term modulation of anxiety-like behavior

Combined exposure to tobacco smoke and ethanol in adolescent mice elicits memory and learning deficits both during exposure and withdrawal

Concurrent maternal and pup postnatal tobacco smoke exposure in Wistar rats changes food preference and dopaminergic reward system parameters in the adult male offspring

Developmental alcohol exposure leads to a persistent change on astrocyte secretome.

Developmental plasticity in adrenal function and leptin production primed by nicotine exposure during lactation: gender differences in rats.

Dietary calcium supplementation in adult rats reverts brown adipose tissue dysfunction programmed by postnatal early overfeeding

Early callosal absence disrupts the establishment of normal neocortical structure in Swiss mice

Early weaning by maternal prolactin inhibition leads to higher neuropeptide Y and astrogliosis in the hypothalamus of the adult rat offspring

Early weaning is associated with higher neuropeptide Y (NPY) and lower cocaine- and amphetamine-regulated transcript (CART) expressions in the paraventricular nucleus (PVN) in adulthood.

Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation

Effects of callosal agenesis on rotational side preference of BALB/cCF mice in the free swimming test

Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats

Effects of early and late neonatal bromocriptine treatment on hypothalamic neuropeptides, dopaminergic reward system and behavior of adult rats.

Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring

Effects of maternal hyperleptinaemia during lactation on short-term memory/learning, anxiety-like and novelty-seeking behavioral traits of adult male rats.

Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny

Effects of postnatal bromocriptine injection on thyroid function and prolactinemia of rats at adulthood

Energy drink enhances the behavioral effects of alcohol in adolescent mice.

Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain.

Exposure to methamidophos at adulthood elicits depressive-like behavior in mice.

Exposure to nicotine and ethanol in adolescent mice: effects on depressive-like behavior during exposure and withdrawal

Exposure to nicotine increases dopamine receptor content in the mesocorticolimbic pathway of rat dams and offspring during lactation.

Exposure to tobacco smoke containing either high or low levels of nicotine during adolescence: differential effects on choline uptake in the cerebral cortex and hippocampus

GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.

Hippocampal increased cell death and decreased cell density elicited by nicotine and/or ethanol during adolescence are reversed during drug withdrawal.

Hyperactivity and memory/learning deficits evoked by developmental exposure to nicotine and/or ethanol are mitigated by cAMP and cGMP signaling cascades activation.

Hypothalamic Neuropeptides Expression and Hypothalamic Inflammation in Adult Rats that Were Exposed to Tobacco Smoke during Breastfeeding: Sex-Related Differences

Increased lateralization in rotational side preference in male mice rendered acallosal by prenatal gamma irradiation

Individual differences in novelty-seeking behavior but not in anxiety response to a new environment can predict nicotine consumption in adolescent C57BL/6 mice.

Locomotor response to acute nicotine in adolescent mice is altered by maternal undernutrition during lactation

Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.

Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring.

Maternal nicotine exposure during lactation alters hypothalamic neuropeptides expression in the adult rat progeny.

Maternal prolactin inhibition at the end of lactation affects learning/memory and anxiety-like behaviors but not novelty-seeking in adult rat progeny.

Maternal protein-free diet during lactation programs male Wistar rat offspring for increased novelty-seeking, locomotor activity, and visuospatial performance.

Maternal undernutrition during lactation alters nicotine reward and DOPAC/dopamine ratio in cerebral cortex in adolescent mice, but does not affect nicotine-induced nAChRs upregulation.

Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior.

Neonatal Nicotine Exposure Leads to Hypothalamic Gliosis in Adult Overweight Rats.

Neonatal hyperleptinaemia programmes anxiety-like and novelty seeking behaviours but not memory/learning in adult rats.

Neonatal phencyclidine as a model of sex-biased schizophrenia symptomatology in adolescent mice

Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats.

Neonatal transection of the corpus callosum affects paw preference lateralization of adult Swiss mice.

Neonatal transection of the corpus callosum affects rotational side preference in adult Swiss mice.

Nicotine and ethanol interact during adolescence: effects on the central cholinergic systems

Ontogenetic analysis of behavior in the tail suspension test: temporal differences in the emergence of within- and between-session habituation in Swiss mice.

Prenatal Systemic Hypoxia-Ischemia and Oligodendroglia Loss in Cerebellum.

Prenatal hypoxic-ischemic insult changes the distribution and number of NADPH-diaphorase cells in the cerebellum

Sex differences in the incidence of total callosal agenesis in BALB/cCF mice.

Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats

Single Cocaine Exposure Inhibits GABA Uptake via Dopamine D1-Like Receptors in Adolescent Mice Frontal Cortex

Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms.

The effect of D-serine administration on cognition and mood in older adults

The effect of corpus callosum agenesis on neocortical thickness and neuronal density of BALB/cCF mice.

The effects of total and partial callosal agenesis on the development of paw preference performance in the BALB/cCF mouse

Thyroid hormone deficiency changes the distribution of oligodendrocyte/myelin markers during oligodendroglial differentiation in vitro

Tobacco and alcohol use during adolescence: Interactive mechanisms in animal models.

Tobacco smoke and ethanol during adolescence: Both combined- and single-drug exposures lead to short- and long-term disruption of the serotonergic system in the mouse brain

Tobacco smoke containing high or low levels of nicotine during adolescence: effects on novelty-seeking and anxiety-like behaviors in mice

Ultrastructural identification of oligodendrocyte/myelin proteins in corpus callosum of hypothyroid animals.

Undernutrition during early life alters neuropeptide Y distribution along the arcuate/paraventricular pathway.

Unilateral hemispherectomy at adulthood asymmetrically affects immobile behavior of male Swiss mice.

Unilateral hemispherectomy at adulthood asymmetrically affects motor performance of male Swiss mice.

Value of combining activated brain FDG-PET and cardiac MIBG for the differential diagnosis of dementia: differentiation of dementia with Lewy bodies and Alzheimer disease when the diagnoses based on clinical and neuroimaging criteria are difficult.

Visual defects in a mouse model of fetal alcohol spectrum disorder.