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List of works by Dominique Schols

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood

scientific article published in 1991

135 Safety Concerns for Cyanovirin as a Microbicidal Anti-HIV Agent

article

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri

scientific article (publication date: 15 May 1992)

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action

scientific article

2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections

scientific article published on September 2002

229

4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist

scientific article published on 14 June 2019

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4.

scientific article

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

A Novel Small-molecule CCR5 Agonist, ESN-196, with Potent R5 HIV-1 Activity

article

A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide

scientific article published on 02 September 2021

A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).

scientific article published on 20 December 2016

A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening

scientific article published on 18 March 2022

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

scientific article published on 02 March 2020

A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro

scientific article

A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells

scientific article

A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.

scientific article

A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity

scientific article (publication date: 2013)

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

scientific article

A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury

scientific article

A short hairpin loop-structured oligodeoxynucleotide targeting the virion-associated RNase H of HIV inhibits HIV production in cell culture and in huPBL-SCID mice

scientific article

A unique class of lignin derivatives displays broad anti-HIV activity by interacting with the viral envelope

scientific article published on 13 October 2019

A yellow fever-Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

scientific article published on 13 December 2018

AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity

scientific article published on April 2002

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

scientific article published in January 1998

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

scientific article published on September 2005

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles

scientific article published on 01 February 2019

Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope

scientific article published on 24 May 2010

Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes

scientific article

Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.

scientific article

Acyclic nucleoside phosphonates containing the amide bond

scientific article published on 26 October 2016

Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.

scientific article

Advantages and shortcomings of cell-based electrical impedance measurements as a GPCR drug discovery tool

scientific article published on 28 April 2019

Agonist-induced internalization of CC chemokine receptor 5 as a mechanism to inhibit HIV replication

scientific article published on 9 March 2011

Algal lectins as potential HIV microbicide candidates

scientific article

Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

scientific article

Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives

scientific article

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

scientific article published on 23 March 2015

An efficient one-pot conversion of Boc-protected adenines to N 6 -ureas

Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor

scientific article published in October 2005

Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras

scientific article

Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes

scientific article (publication date: 20 October 1992)

Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives

scientific article published on 28 September 2019

Antiviral Activity of Carbohydrate Binding Agents (CBAS) and the Role of DC-SIGN in Dengue Virus and HIV Infection

article

Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique

scientific article (publication date: July 1991)

Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection

scientific article

Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.

scientific article

Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure

scientific article published on May 2004

Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes

scientific article published on 26 July 2016

Assessment of protein biomarkers for preoperative differential diagnosis between benign and malignant ovarian tumors

scientific article published on 26 September 2020

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors

scientific article published on 14 July 2018

Azithromycin and the treatment of lymphocytic airway inflammation after lung transplantation

scientific article published on 13 November 2014

BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance

scientific article published on 11 July 2015

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4 ⬇️

scientific article published on August 1, 1997

Bis(benzoyloxybenzyl)-DiPPro nucleoside diphosphates of anti-HIV active nucleoside analogues

scientific article

Branched-chain sugar nucleosides: stereocontrolled synthesis and bioevaluation of novel 3'-C-trifluoromethyl and 3'-C-methyl pyranonucleosides

scientific article

Broad Antiviral Activity of Carbohydrate-Binding Agents Against Dengue Virus Infection

Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family

scientific article

Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells

scientific article

CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor

scientific article published on October 2002

CADA, a Potential Anti-HIV Microbicide that Specifically Targets the Cellular CD4 Receptor

article

CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro

scientific article

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor

scientific article published in May 2008

CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.

scientific article

CD4 down-modulating compounds with potent anti-HIV activity

scientific article published on January 2004

CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.

scientific article published on January 2010

CXCR4 Antagonists: A New Generation of Configurationally Restricted Bis-azamacrocyclic Compounds

scientific article published in 2009

CXCR4 Chemokine Receptor Antagonists from Ultra-rigid Metal Complexes Profoundly Inhibit HIV-1 Replication, and also AMD3100-resistant Strains

article

CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection

scientific article published on 7 March 2011

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles

scientific article published on 14 August 2012

CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes

scientific article published in October 2001

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

scientific article

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

scientific article

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells.

scientific article

Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions

scientific article

Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120

scientific article published in Journal of Biological Chemistry

Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes

article

Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes

scientific article published on 20 October 2006

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

scientific article published in September 2002

Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity.

scientific article published on 30 January 2018

Chloroquine accumulates in breast-milk cells: potential impact in the prophylaxis of postnatal mother-to-child transmission of HIV-1

article

Citrullination of CXCL12 affects its inflammatory and anti-HIV-1 activity

article

Combination of the CCL5-derived peptide R4.0 with different HIV-1 blockers reveals wide target compatibility and synergic cobinding to CCR5

scientific article published on 11 August 2014

Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains

scientific article

Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus

scientific article published on December 1991

Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors

scientific article

Coreceptor ligand inhibition of fetal brain cell infection by HIV type 1.

scientific article published in July 1999

Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence

scientific article

Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products

scientific article published on 19 January 2017

Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection

scientific article

Cyclotriazadisulfonamides: promising new CD4-targeted anti-HIV drugs

scientific article

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.

scientific article

Dengue virus entry as target for antiviral therapy

scientific article published on 4 March 2012

Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity

scientific article

Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

scientific article published on 8 October 2011

Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication

scientific article published on 23 February 2011

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

scientific article published on 11 January 2011

Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication

scientific article published on 3 October 2013

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type.

scientific article published on 28 November 2016

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates

scientific article published on 17 November 2015

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

scientific article published on 24 February 2019

Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides

scientific article

Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues

scientific article published on 6 May 2015

Design, synthesis and antiviral evaluation of novel acyclic phosphonate nucleotide analogs with triazolo[4,5-b]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-b]pyridin-2(3H)-one systems

scientific article published on 25 September 2019

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization

scientific article published on 18 February 2020

Design, synthesis, and cytostatic activity of novel pyrazine sorafenib analogs

Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues

scientific article

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

scholarly article by Delia Preti et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase.

scientific article

Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection

scientific article

Development of a cell-based enzyme-linked immunosorbent assay for high-throughput screening of HIV type 1 entry inhibitors targeting the coreceptor CXCR4.

scientific article published on November 2003

Development of new potent and selective agents against HIV (human immunodeficiency virus)

scientific article published on January 1, 1991

Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.

scientific article published on April 1990

Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues

Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity

scientific article published on 11 February 2011

Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.

scientific article published on 22 December 2017

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

scientific article published on November 2010

Differential Cytokine, Chemokine and Growth Factor Expression in Phenotypes of Chronic Lung Allograft Dysfunction

scientific article published on 01 January 2015

Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization

scientific article

Differential antiviral activity of derivatized dextrans

scientific article

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development

scientific article published on 12 June 2007

Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity

scientific article published on 01 January 2020

Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties

scientific article published on 04 February 2016

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

scientific article published on April 2010

Disulfide-containing macrolides that inhibit a late stage of the replicative cycle of human immunodeficiency virus

scientific article published in 1997

Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils

scientific article (publication date: July 2001)

Diversion of the Arbuzov reaction: alkylation of C-Cl instead of phosphonic ester formation on the fullerene cage

scientific article published on 06 June 2019

Dual anti-HSV and anti-HIV activity of the lantibiotic Labyrinthopeptin A1

article

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir

scientific article published on 6 June 2011

Early protein expression profile in bronchoalveolar lavage fluid and clinical outcomes in primary graft dysfunction after lung transplantation

scientific article published on 08 April 2020

Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin

article

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity

scientific article

Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions

scientific article

Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

scientific article

Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry

scientific article published on January 2003

Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis

scientific article published on 26 June 2012

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

scientific article published on 6 July 2017

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs

scholarly article by Elisa Pileggi published in July 2018

Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

scientific article published on 03 March 2016

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency

scientific article

Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products

scientific article published on 5 January 2017

Feglymycin, a Unique 13 Amino-acid Peptide, With a Novel Mechanism of Anti-HIV-1 Activity

article

Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120.

scientific article published on 7 September 2012

Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents

scientific article

Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells

scientific article published on January 1990

Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies

scientific article published on October 2004

HIV chemokine receptor inhibitors as novel anti-HIV drugs

scientific article

HIV co-receptor inhibitors as novel class of anti-HIV drugs

scientific article

HIV co-receptors as targets for antiviral therapy

scientific article

HIV coreceptor CXCR4 antagonists

scientific article published on September 2006

HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship

scientific article

HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview.

scientific article

HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay

scientific article published on 9 March 2011

HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling

scientific article published in November 2001

HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation

scientific article

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.

scientific article

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor.

scientific article published in June 2019

Human immunodeficiency virus gp120 as the primary target of action of AR177 (Zintevir)

scientific article published in 1997

Human immunodeficiency virus type 1 escape from cyclotriazadisulfonamide-induced CD4-targeted entry inhibition is associated with increased neutralizing antibody susceptibility

scientific article

Humoral immunity in phenotypes of chronic lung allograft dysfunction: A broncho-alveolar lavage fluid analysis

scientific article published on 22 August 2016

Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells

scientific article

Immunocytochemical demonstration of proopiomelanocortin- and other opioid-related substances and a CRF-like peptide in the gut of the american cockroach, Periplaneta americana L.

scientific article published in January 1987

Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model

scientific article

Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants

scientific article

Improving potencies and properties of CD4 down-modulating CADA analogs

scientific article published on 06 December 2011

In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).

scientific article published on 29 October 2009

In vivo evolution of X4 human immunodeficiency virus type 1 variants in the natural course of infection coincides with decreasing sensitivity to CXCR4 antagonists

scientific article published on March 2004

In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells

scientific article

In-Depth Characterization of Zika Virus Inhibitors Using Cell-Based Electrical Impedance

scientific article published on 11 July 2022

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide

scientific article

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 24 November 2014

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

scientific article

Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

scientific article published on December 2004

Inhibitors of HIV infection via the cellular CD4 receptor

scientific article

Interactions of the HIV fusion inhibitor AR177 (ZINTEVIR) with the HIV type I second receptor

article

Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma

scientific article

Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven

scientific article published in 2006

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate

scientific article (publication date: 2011)

Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity

scientific article published on 28 July 2018

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index.

scientific article published on 7 June 2018

Labyrinthopeptins Exert Broad-Spectrum Antiviral Activity through Lipid-Binding-Mediated Virolysis

scientific article published on 06 January 2020

Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins

scientific article published on 12 July 2016

Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation

scientific article

Lignosulfonic acid exhibits broad-spectrum anti-HIV and anti-HSV activity and has potential for microbicidal applications

article

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

scientific article published on 27 October 2015

Long-lasting enfuvirtide carrier pentasaccharide conjugates with potent anti-human immunodeficiency virus type 1 activity

scientific article

Long-term use of cocaine and late-onset torticollis.

scientific article published on 11 January 2010

Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture.

scientific article

Macrocyclic Polyamines Targeting the Cellular HIV Co-receptors, CXCR4 and CCR5

article

Macrocyclic polyamines inhibit HIV infection by interacting with the cellular HIV co-receptors CXCR4 and CCR5.

scientific article published on 24 September 2009

Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity

scientific article

Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection

scientific article published on October 2004

Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.

scientific article published on 17 February 2005

Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies

scientific article published on 24 August 2006

Membrane permeable, bioreversibly modified Prodrugs of Nucleoside Diphosphate-γ-phosphonates

scientific article published on 29 September 2020

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues

scientific article published on 23 March 2016

Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4.

scientific article published on 4 September 2015

Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile

scientific article

Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication

scientific article

Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

scientific article published on 24 January 2007

Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum

scientific article published on 20 June 2019

Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

scientific article

Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes

scientific article

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

scientific article published in July 2003

NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles

scientific article published on 19 February 2015

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities.

scientific article published on March 2015

New Isoxazolidine-Conjugates of Quinazolinones-Synthesis, Antiviral and Cytostatic Activity.

scientific article published on 22 July 2016

New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship

scientific article published on 10 February 2018

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

No selection for CCR5 coreceptor usage during parenteral transmission of macrophagetropic syncytium-inducing human immunodeficiency virus type 1.

scientific article

Novel Isoxazolidine and γ-Lactam Analogues of Homonucleosides

scientific article published on 06 November 2019

Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.

scientific article published on 10 August 2015

Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives

scientific article published on 22 January 2007

Novel isoxazolidine analogues of homonucleosides and homonucleotides

scientific article published on 02 November 2016

Novel recombinant virus assay for measuring susceptibility of human immunodeficiency virus type 1 group M subtypes to clinically approved drugs

scientific article published on 29 April 2009

Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: synthesis, cytostatic and antioxidative activity

scientific article published on 6 September 2014

Novel urea and bis-urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation.

scientific article published on 24 August 2016

Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

scientific article published on June 1999

Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides

scientific article

Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

scientific article

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation and Anti-HIV-1 Activity

article

Phosphonylated 8-Azahypoxantines as Acyclic Nucleotide Analogs

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker.

scientific article published on 16 October 2015

Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.

scientific article published on December 1998

Polyfunctionalized Pyrrole Derivatives: Easy Three-component Microwave-assisted Synthesis, Cytostatic and Antiviral Evaluation

scholarly article published 30 April 2018

Polysulfonates derived from metal thiolate complexes as inhibitors of HIV-1 and various other enveloped viruses in vitro.

scientific article published on May 2002

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase

scientific article

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

scientific article

Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action

scientific article

Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus

scientific article published on 18 October 2006

Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.

scientific article

Pradimicin-S is a Highly Soluble Non-peptidic Small-size Carbohydrate-binding Antibiotic that may Qualify as a Potential Drug Lead for HIV Treatment

article

Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.

scientific article

Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight

scientific article

Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect

article

Preprotein signature for full susceptibility to the co-translational translocation inhibitor cyclotriazadisulfonamide

scientific article published on 25 November 2019

Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles

scientific article

Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis

scientific article

Productive infection of primary macrophages with human herpesvirus 7.

scientific article published on November 2001

Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins

scientific article published on October 2004

Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells.

scientific article published on January 2007

Prone Positioning During Ex Vivo Lung Perfusion Influences Regional Edema Accumulation

scientific article published on 19 March 2019

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines

scientific article published on 22 November 2006

Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach

article

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action

scientific article

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

scientific article (publication date: August 1988)

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors

scientific article published on 20 August 2008

Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.

scientific article published on 21 November 2006

Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor

scientific article published on 12 June 2011

Restricted Entry of R5 HIV Type 1 Strains into Eosinophilic Cells

article

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

scientific article published on 24 April 2020

SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[2,1- b][1,3,4]THIADIAZOLE DERIVATIVES

scholarly article by Arpit Katiyar et al published September 2016 in Acta Poloniae Pharmaceutica: drug research

Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent

article

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

scientific article

Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors

scientific article published on 20 December 2019

Selective activity of various antiviral compounds against HHV-7 infection

scientific article

Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).

scientific article published on November 1990

Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anticytomegalovirus agents

scientific article published on 01 November 1991

Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation

scientific article (publication date: December 2014)

Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements

scientific article published on 25 September 2017

Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development

scientific article published on 12 May 2008

Specific CD4 down-modulating compounds with potent anti-HIV activity

scientific article

Steroids can reduce warm ischemic reperfusion injury in a porcine donation after circulatory death model with ex vivo lung perfusion evaluation

scientific article published on 12 August 2016

Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model

scientific article published on 13 May 2022

Structural analogs of umifenovir 2*. The synthesis and antiHIV activity study of new regioisomeric (trans-2-phenylcyclopropyl)-1Н-indole derivatives

article

Structure investigation and anti-HIV activities of high-molecular weight ATA polymers

article

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

scientific article published on 22 December 2016

Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3-Amino-1,2,4-triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products

Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer

scientific article

Sulfated Escherichia coli K5 polysaccharide derivatives inhibit dengue virus infection of human microvascular endothelial cells by interacting with the viral envelope protein E domain III.

scientific article

Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate

article

Sulfonic acid polymers as a new class of human immunodeficiency virus inhibitors

scientific article (publication date: June 1992)

Susceptibility of diverse primary HIV isolates with varying co-receptor specificity's to CXCR4 antagonistic compounds

scientific article

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C.

scientific article published on 28 July 2011

Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).

scientific article published on 8 April 2011

Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units

scientific article published on 29 October 2018

Synthesis and Antiviral Evaluation of TriPPP ro-AbacavirTP, TriPPP ro-CarbovirTP, and Their 1′,2′-cis -Disubstituted Analogues

scientific article published on 25 July 2018

Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).

scientific article published on 07 March 2017

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides.

scientific article published on 8 February 2016

Synthesis and Evaluations of "1,4-Triazolyl Combretacoumarins" and Desmethoxy Analogues

scientific article published on 07 August 2019

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

scientific article published on 6 November 2010

Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds

scientific article

Synthesis and anti-HIV activity of guanine modified fluorinated acyclic nucleoside phosphonates derivatives

article

Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

article

Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues

scientific article published on February 2006

Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication

scientific article

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4

scientific article

Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates.

scientific article published on 26 October 2016

Synthesis of CADA Analog Prodrugs Designed as Novel Down-modulators of the CD4 Receptor

scientific article published in 2009

Synthesis of Enantiomerically Pure 1′,2′-cis-dideoxy, -dideoxydidehydro, -ribo and -deoxy Carbocyclic Nucleoside Analogues

Synthesis of Novel CADA Analog Prodrugs Designed as Down-Modulators of the CD4 Receptor

scientific article published in 2011

Synthesis of Novel Chiral Sulfonamide-Bearing 1,2,4-Triazole-3-thione Analogs Derived from D- and L-Phenylalanine Esters as Potential Anti-Influenza Agents

scientific article

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

Synthesis of different types of alkoxy fullerene derivatives from chlorofullerene C60Cl6

scientific article published on 01 January 2017

Synthesis of novel N-acyl-β-d-glucopyranosylamines and ureas as potential lead cytostatic agents

scientific article published on 29 February 2016

Synthesis of novel thiopurine pyranonucleosides: evaluation of their bioactivity

scientific article

Synthesis, Anti-varicella-zoster virus and Anti-cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures

scientific article published on 04 October 2016

Synthesis, antiviral, cytotoxic and cytostatic evaluation of N 1-(phosphonoalkyl)uracil derivatives

scientific article published on 01 March 2016

Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids

scientific article published on 13 July 2011

Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds

scientific article published in December 1989

The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor

scientific article

The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages

scientific article published on May 2001

The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine

scientific article published on August 1999

The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications

scientific article

The Role of CD26/DPP IV in Chemokine Processing

The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

scientific article

The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level

scientific article

The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1

article

The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications

scientific article

The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens.

scientific article

The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor

scientific article

The orally bioavailable allosteric CXCR4 HIV-1 entry inhibitor AMD11070.

scientific article published on 25 May 2012

The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential

scientific article

The role of N-glycosylation sites on the CXCR4 receptor for CXCL-12 binding and signaling and X4 HIV-1 viral infectivity

scientific article published on 28 February 2007

Therapeutic strategies towards HIV-1 infection in macrophages

scientific article published on 9 June 2006

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.

scientific article published on 3 January 2012

Total synthesis of the antiviral peptide antibiotic feglymycin

scientific article

Toward Unsymmetrical CADA Analogs as Novel Down-modulators of the CD4 Receptor

scientific article published in 2009

Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties

scientific article published on 22 September 2018

Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction

scientific article

Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes

scientific article published on 21 February 2020

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies.

scientific article published on 14 March 2016

Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents

scientific article published on 29 July 2011

Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers

scientific article published on 7 January 2016

Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation

scientific article published on 25 October 2006

Virus-inhibitory peptide: a natural HIV entry inhibitor in search for a formal target in the viral genome

scientific article published in August 2011

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