List of works - Sheng-Xiang Lin

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration

scientific article

17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production

scientific article

17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation

scientific article

3D-structure of human estrogenic 17beta-HSD1: binding with various steroids.

scientific article

3D-structure of human estrogenic 17β-HSD1: binding with various steroids

scientific article published on 01 June 2000

A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.

scientific article published on January 2013

A technique of protein addition for repeated enlargement of protein crystals in solution

An Extensive Study of Protein Phase Diagram Modification: Increasing Macromolecular Crystallizability by Temperature Screening†

scholarly article by Yi-Bin Lin et al published 3 December 2008 in Crystal Growth & Design

Arginyl-tRNA synthetase from Escherichia coli, purification by affinity chromatography, properties, and steady-state kinetics

scientific article published in August 1988

Attempts to rationalize protein crystallization using relative crystallizability

scientific article published on 23 March 2006

Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy

scientific article

CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity

scientific article published on 17 January 2019

Chemical synthesis of 16beta-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17beta-hydroxysteroid dehydrogenase and binding affinity on steroid receptors.

scientific article

Cinnamomin: separation, crystallization and preliminary X-ray diffraction study

scientific article published on 4 April 2007

Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation

scientific article

Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide

scientific article published on 31 August 2018

Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7

scientific article

Critical Residues for the Specificity of Cofactors and Substrates in Human Estrogenic 17β-Hydroxysteroid Dehydrogenase 1: Variants Designed from the Three-Dimensional Structure of the Enzyme ⬇️

scientific article published on November 1, 2001

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

scientific article

Crystal structure of chloramphenicol acetyltransferase B2 encoded by the multiresistance transposon Tn2424

scholarly article by Wei Qiu published in January 2004

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol

scientific article

Crystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteins

scientific article

Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition

scientific article published on 03 April 2019

Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues

scientific article published on 15 April 2004

Crystallization and Preliminary X-ray Diffraction Analysis of the Complex of Human Placental 17β-Hydroxysteroid Dehydrogenase with NADP+

article

Crystallization and preliminary X-ray diffraction analysis of E. coli arginyl-tRNA synthetase in complex form with a tRNAArg.

scientific article

Crystallization and preliminary crystal structure of the complex of 17β-hydroxysteroid dehydrogenase with a dual-site inhibitor

scientific article published on 01 September 1999

Crystallization and preliminary crystallographic analysis of the snake muscle fructose 1,6-bisphosphatase

scientific article published on 01 July 1999

Crystallization and preliminary crystallographic data of fructose-1,6-bisphosphatase from human muscle.

scientific article

Crystallization and preliminary crystallographic results of apo and complex forms of human dehydroepiandrosterone sulfotransferase.

scientific article published on 25 October 2001

Crystallization of human estrogenic 17β-hydroxysteroid dehydrogenase under microgravity

Crystallization of the Membrane-Associated Annexin B1: Roles of Additive Screen, Dynamic Light Scattering, and Bioactivity Assay

Crystallogenesis of Steroid-Converting Enzymes and Their Complexes: Enzyme–Ligand Interaction Studies and Inhibitor Design Facilitated by Complex Structures†

article

Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).

scientific article published on 18 April 2016

Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.

scientific article published on 16 May 2016

Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitors

scientific article (publication date: 2013)

Electrophoresis of hydrophobic proteins

Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone

scientific article

Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase

scientific article published on December 2005

Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1.

scientific article published on 17 August 2016

Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase

scientific article published on 7 December 2005

Fast kinetic study of yeast phenylalanyl-tRNA synthetase: an efficient discrimination between tyrosine and phenylalanine at the level of the aminoacyladenylate-enzyme complex

scientific article published on 01 February 1983

Fast kinetic study of yeast phenylalanyl-tRNA synthetase: role of tRNAPhe in the discrimination between tyrosine and phenylalanine

scientific article published in August 1984

Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol

scientific article

Good Crystals, Still a Challenge for Structural Biology†

article

Higher specific activity of the Escherichia coli glutamyl-tRNA synthetase purified to homogeneity by a six-hour procedure.

scientific article published in February 1992

Human 17 beta-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization.

scientific article published on September 1994

Human 17β-hydroxysteroid dehydrogenase: optical properties of its complex with NADP+

scientific article published on 01 January 1995

Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity

scientific article

Human 3α-hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth

scientific article

Human Estrogenic 17β-Hydroxysteroid Dehydrogenase: Predominance of Estrone Reduction and Its Induction by NADPH

article by Jiu-Zhen Jin & Sheng-Xiang Lin published June 1999 in Biochemical and Biophysical Research Communications

Human SARS-coronavirus RNA-dependent RNA polymerase: activity determinants and nucleoside analogue inhibitors

scientific article

Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction

scientific article

Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex

scientific article

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

scientific article published on 28 October 2015

In vitro interactions between mammary fibroblasts (Hs 578Bst) and cancer epithelial cells (MCF-7) modulate aromatase, steroid sulfatase and 17β-hydroxysteroid dehydrogenases

scientific article published in June 2015

Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.

scientific article

Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane-3β,17β-diol with estrogen and androgen receptors: a combined binding and cell study

scientific article published on 14 February 2013

Mapping of steroids binding to 17 beta-hydroxysteroid dehydrogenase type 1 using Monte Carlo energy minimization reveals alternative binding modes

scientific article published in May 2005

Mimicking postmenopausal steroid metabolism in breast cancer cell culture: Differences in response to DHEA or other steroids as hormone sources

article

Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.

scientific article published on June 1995

Molecular therapy of breast cancer: progress and future directions

scientific article published on 20 July 2010

Monoclonal antibodies assisting refolding of firefly luciferase

scientific article published in July 2004

Novel Coronavirus Polymerase and Nucleotidyl-transferase Structures: Potential to Target New Outbreaks

scientific article published on 11 May 2020

Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity

scientific article published in January 2010

Preparation of the apoenzyme and holoenzyme forms of human 17β-hydroxysteroid dehydrogenase

scientific article published on 01 April 1993

Preparative fast purification procedure of various proteins for crystallization

Progress in Macromolecular Crystallogenesis

scholarly article by Sheng-Xiang Lin et al published November 2007 in Crystal Growth & Design

Protein crystal growth on board Shenzhou 3: a concerted effort improves crystal diffraction quality and facilitates structure determination.

scientific article

Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

scientific article

Purification, Refolding, Crystallization and Diffraction Analysis of the Native and Selenomethionine-Substituted Rat Epidymal-Specific Lipocalin†

Purification, crystallization and preliminary X-ray diffraction results of human 17β-hydroxysteroid dehydrogenase type 5

scientific article published on 29 May 2002

Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2

scientific article (publication date: 21 June 2002)

RNA-dependent RNA polymerase: Addressing Zika outbreak by a phylogeny-based drug target study

scientific article published on 21 June 2017

Rapid purification yielding highly active 17β-hydroxysteroid dehydrogenase: application of hydrophobic interaction and affinity fast protein liquid chromatography

scientific article published on 01 November 1992

Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet

scientific article

Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer

scientific article

Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells

scientific article published on 23 September 2014

Stoichiometry of slow binding of palmitoyl-CoA to liver glucokinase

scientific article published in October 1989

Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors

scientific article (publication date: 21 December 2016)

Structure Analysis of a New Psychrophilic Marine Protease

scientific article

Structure function analysis of west nile virus RNA dependent RNA polymerase: molecular model and implications for drug design

scientific article published on September 2007

Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution ⬇️

scientific article published on May 15, 1995

Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase

scientific article

Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown

scientific article

Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer

scientific article

Synthesis of a First Estradiol-Adenosine Hybrid Compound

article

The Study of Crystallization of Estrogenic 17β-Hydroxysteroid Dehydrogenase with DHEA and DHT at Elevated Temperature

article published in 2000

The Ternary Structure of the Double-headed Arrowhead Protease Inhibitor API-A Complexed with Two Trypsins Reveals a Novel Reactive Site Conformation

scientific article

The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells

scientific article

The glutamyl-tRNA synthetase of Escherichia coli contains one atom of zinc essential for its native conformation and its catalytic activity.

scientific article published on October 1993

The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm.

scientific article published in February 2004

Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis

scientific article published in March 1999

Yeast phenylalanyl-tRNA synthetase: symmetric behavior of the enzyme during activation of phenylalanine as shown by a rapid kinetic investigation

scientific article published on 01 February 1983

List of works by Sheng-Xiang Lin

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration

17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production

17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation

3D-structure of human estrogenic 17beta-HSD1: binding with various steroids.

3D-structure of human estrogenic 17β-HSD1: binding with various steroids

A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.

A technique of protein addition for repeated enlargement of protein crystals in solution

An Extensive Study of Protein Phase Diagram Modification: Increasing Macromolecular Crystallizability by Temperature Screening†

Arginyl-tRNA synthetase from Escherichia coli, purification by affinity chromatography, properties, and steady-state kinetics

Attempts to rationalize protein crystallization using relative crystallizability

Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy

CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity

Chemical synthesis of 16beta-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17beta-hydroxysteroid dehydrogenase and binding affinity on steroid receptors.

Cinnamomin: separation, crystallization and preliminary X-ray diffraction study

Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation

Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide

Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7

Critical Residues for the Specificity of Cofactors and Substrates in Human Estrogenic 17β-Hydroxysteroid Dehydrogenase 1: Variants Designed from the Three-Dimensional Structure of the Enzyme ⬇️

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

Crystal structure of chloramphenicol acetyltransferase B2 encoded by the multiresistance transposon Tn2424

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol

Crystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteins

Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition

Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues

Crystallization and Preliminary X-ray Diffraction Analysis of the Complex of Human Placental 17β-Hydroxysteroid Dehydrogenase with NADP+

Crystallization and preliminary X-ray diffraction analysis of E. coli arginyl-tRNA synthetase in complex form with a tRNAArg.

Crystallization and preliminary crystal structure of the complex of 17β-hydroxysteroid dehydrogenase with a dual-site inhibitor

Crystallization and preliminary crystallographic analysis of the snake muscle fructose 1,6-bisphosphatase

Crystallization and preliminary crystallographic data of fructose-1,6-bisphosphatase from human muscle.

Crystallization and preliminary crystallographic results of apo and complex forms of human dehydroepiandrosterone sulfotransferase.

Crystallization of human estrogenic 17β-hydroxysteroid dehydrogenase under microgravity

Crystallization of the Membrane-Associated Annexin B1: Roles of Additive Screen, Dynamic Light Scattering, and Bioactivity Assay

Crystallogenesis of Steroid-Converting Enzymes and Their Complexes: Enzyme–Ligand Interaction Studies and Inhibitor Design Facilitated by Complex Structures†

Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).

Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.

Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitors

Electrophoresis of hydrophobic proteins

Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone

Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase

Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1.

Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase

Fast kinetic study of yeast phenylalanyl-tRNA synthetase: an efficient discrimination between tyrosine and phenylalanine at the level of the aminoacyladenylate-enzyme complex

Fast kinetic study of yeast phenylalanyl-tRNA synthetase: role of tRNAPhe in the discrimination between tyrosine and phenylalanine

Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol

Good Crystals, Still a Challenge for Structural Biology†

Higher specific activity of the Escherichia coli glutamyl-tRNA synthetase purified to homogeneity by a six-hour procedure.

Human 17 beta-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization.

Human 17β-hydroxysteroid dehydrogenase: optical properties of its complex with NADP+

Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity

Human 3α-hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth

Human Estrogenic 17β-Hydroxysteroid Dehydrogenase: Predominance of Estrone Reduction and Its Induction by NADPH

Human SARS-coronavirus RNA-dependent RNA polymerase: activity determinants and nucleoside analogue inhibitors

Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction

Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

In vitro interactions between mammary fibroblasts (Hs 578Bst) and cancer epithelial cells (MCF-7) modulate aromatase, steroid sulfatase and 17β-hydroxysteroid dehydrogenases

Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.

Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane-3β,17β-diol with estrogen and androgen receptors: a combined binding and cell study

Mapping of steroids binding to 17 beta-hydroxysteroid dehydrogenase type 1 using Monte Carlo energy minimization reveals alternative binding modes

Mimicking postmenopausal steroid metabolism in breast cancer cell culture: Differences in response to DHEA or other steroids as hormone sources

Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.

Molecular therapy of breast cancer: progress and future directions

Monoclonal antibodies assisting refolding of firefly luciferase

Novel Coronavirus Polymerase and Nucleotidyl-transferase Structures: Potential to Target New Outbreaks

Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity

Preparation of the apoenzyme and holoenzyme forms of human 17β-hydroxysteroid dehydrogenase

Preparative fast purification procedure of various proteins for crystallization

Progress in Macromolecular Crystallogenesis

Protein crystal growth on board Shenzhou 3: a concerted effort improves crystal diffraction quality and facilitates structure determination.

Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1.

Purification, Refolding, Crystallization and Diffraction Analysis of the Native and Selenomethionine-Substituted Rat Epidymal-Specific Lipocalin†

Purification, crystallization and preliminary X-ray diffraction results of human 17β-hydroxysteroid dehydrogenase type 5

Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2

RNA-dependent RNA polymerase: Addressing Zika outbreak by a phylogeny-based drug target study

Rapid purification yielding highly active 17β-hydroxysteroid dehydrogenase: application of hydrophobic interaction and affinity fast protein liquid chromatography

Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet

Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer

Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells

Stoichiometry of slow binding of palmitoyl-CoA to liver glucokinase