List of works - Anne O'Garra

A 380-gene meta-signature of active tuberculosis compared with healthy controls

scientific article published on 13 April 2016

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

scientific article (publication date: 16 October 1997)

A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma

scientific article published on 22 August 2019

A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production

scientific article

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

scientific article published on 9 November 2017

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection.

scientific article

A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure

scientific article published in February 2002

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

scientific journal article

Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

scientific article

An interferon signature is associated with HAM/TSP but not viral containment in HTLV-1 infection

scientific article published on 6 June 2011

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis ⬇️

scientific article (publication date: 19 August 2010)

Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling

scientific article

Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide

scientific article

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells

scientific article

Are dendritic cells afraid of commitment?

scientific article published in December 2004

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

scientific article published on 01 March 2019

B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis

scientific article published on 21 November 2017

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

scientific article

Biological properties of interleukin 10

scientific article published on 01 July 1992

Biological properties of interleukin 10.

scientific article

Biology and therapeutic potential of interleukin-10

scientific article published on 01 January 2020

Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection

scientific article

Breakpoints in immunoregulation required for Th1 cells to induce diabetes

scientific article published on 01 September 2006

Brigitte Askonas (1923–2013) ⬇️

scientific article published on February 7, 2013

CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.

scientific article published on 31 January 2005

CD4+ T-cell subsets in autoimmunity

scientific article published on December 1997

CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection

scientific article published in December 1997

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography

scientific article published on 05 September 2016

Checkpoints for regulation of development and IFN-gamma production by Th1 cells in TCR-transgenic models

scientific article

Commit ye helpers

scientific article published in Nature

Commitment factors for T helper cells

scientific article published in June 2000

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

scientific article published on 16 January 2018

Contribution of cytokines to pathology and protection in virus infection

scientific article published on 25 June 2011

Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

scientific article published in December 2016

Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei

scientific article

Cytokine networking in lungs of immunocompetent mice in response to inhaled Aspergillus fumigatus

scientific article published on March 2001

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets ⬇️

scientific article published on March 1, 1998

Cytokines and Ly-1 (B1) B cells

scientific article

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

article

Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

scientific article

Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice

scientific article

Development and function of IL-10-secreting regulatory T cells: Comparison with naturally occurring CD4+CD25+ regulatory T cells

article

Development and function of T helper 1 cells

scientific article published on January 2004

Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

scientific article published on 19 July 2021

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages

scientific article published on 22 August 2016

Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages

scientific article

Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases

scientific article published in November 1999

Differentiation of human TH-17 cells does require TGF-β!

Driving change in tuberculosis research: an interview with Anne O’Garra ⬇️

scientific article published on January 1, 2013

Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B

article

Editorial overview

scientific article published on 04 August 2012

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

scientific article

Erratum: Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

scientific article published in Nature

Establishing the Follicular Helper Identity

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation ⬇️

scientific article

Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development

scientific article

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development

scientific article published on September 2009

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

scientific article

Further checkpoints in Th1 development

scientific article

GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells.

scientific article

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

scientific article published in July 2000

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

scientific article published on May 1999

Glycosylation-dependent modulation of the lL-2 signaling axis determines Th17 differentiation and IL-10 production

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

scientific article

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations

scientific article published on November 1995

High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17IL-10 Memory CD4 T Cell Response towards a Single IL-10-Producing Phenotype

scientific article published on 31 December 2018

Highlights of 10 years of immunology in Nature Reviews Immunology

scientific article published on 23 September 2011

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

scientific article published on 01 April 2019

IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice

scientific article

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage

scientific article

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

scientific article

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection

scientific article published on 28 December 2011

Identification of a macrophage-specific chromatin signature in the IL-10 locus.

scientific article published in July 2005

Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas.

scientific article published in August 1990

Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro

scientific article

Immunology. Immunity benefits from a little suppression.

scientific article published in May 2008

Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection

scientific article

In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines

scientific article

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

scientific article

In vivo manipulation of dendritic cell migration and activation to elicit antitumour immunity.

scientific article published on January 2004

Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis

scientific article

Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway

scientific article published on 09 August 2013

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

Interleukin-10 and the interleukin-10 receptor

scientific article

Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose

scientific article

Interleukins and the immune system 2.

scientific article published on May 1989

JEM women in STEM: Unique journeys with a common purpose

scientific article published on 01 March 2020

Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.

scientific article published in December 2006

Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells

scientific article

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

scientific article published on 16 March 2020

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

article by Carine Asselin-Paturel et al published 19 November 2001 in Nature Immunology

Mouse γδ TCR+NK1.1+ thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to αβ TCR+NK1.1+ thymocytes

scholarly article by Alain P. Vicari et al published July 1996 in European Journal of Immunology

Mycobacterium tuberculosis and its ability to resist immunity

scientific article published on January 2007

NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation

scientific article

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

scientific article published on 29 December 2008

Neutrophils in tuberculosis: friend or foe?

scientific article

Pathogen-induced Th1 phenotype development in CD4+ αβ-TCR transgenic T cells is macrophage dependent

article

Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.

scientific article

Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822.

scientific article

Pillars article: development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. 1993. Science 260(5107): 547-549.

scientific article published in October 2008

Polymerase chain reaction for detection of cytokine gene expression

scientific article

Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma.

scientific article

Preface. The science of infectious diseases ⬇️

scientific article published on 12 May 2014

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

article

Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis

scientific article

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

scientific article

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

article

Quantitative events determine the differentiation and function of helper T cells

scientific article published in April 2011

Regula'ten' the gut

article published in 2007

Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase

scientific article published on 17 March 2014

Regulatory T cells and mechanisms of immune system control

scientific article published in August 2004

Regulatory role of IL4 and other cytokines in T helper cell development in an alpha beta TCR transgenic mouse system

scientific article published on October 1993

Remembering Ralph Steinman

scientific article published on November 2011

Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody

scientific article

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

scientific article

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

scientific article

Role of IL-10 and the IL-10 Receptor in Immune Responses

article

Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection

scientific article published on 27 December 2005

Role of cytokines in determining T-lymphocyte function

scientific article published on June 1994

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

scientific article published on 29 June 2003

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

scientific article published on 03 February 2017

Strategies for use of IL-10 or its antagonists in human disease

scientific article published on June 2008

Systems approach to understand the immune response in tuberculosis: an iterative process between mouse models and human disease

scientific article published on 7 October 2013

Systems approaches to studying the immune response in tuberculosis

scientific article published on 07 September 2013

Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy

scientific article

T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection

scientific article published on 05 June 2017

T cell genetic background determines default T helper phenotype development in vitro

scientific article

T(H)1 cells control themselves by producing interleukin-10.

scientific article published on June 2007

T-cell subsets in autoimmunity

scientific article published on December 1993

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

article

TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

scientific article published on 10 August 2009

TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production

scientific article published on 10 July 2013

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

scientific article published on 01 January 2008

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells

scientific article published on 2 January 2012

The BCL1 B lymphoma responds to IL-4, IL-5, and GM-CSF.

scientific article published in October 1989

The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease

scientific article

The Plasticity of Dendritic Cells Populations in Promoting Th-cell Responses

article

The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis

scientific article

The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis

scientific article

The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor

scientific article

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

scientific article

The human immune response to tuberculosis and its treatment: a view from the blood

scientific article

The immune response in tuberculosis

scientific article published on January 2013

The immunobiology of interleukin 4

The molecular basis of T helper 1 and T helper 2 cell differentiation

scientific article

The regulation of IL-10 expression

scientific article published on January 2014

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells

scientific article

The role of IL-10 in immune regulation during M. tuberculosis infection

scientific article published on 30 March 2011

The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development

scientific article published on September 1995

The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis

scholarly article by Akul Singhania et al published November 2018 in Nature Immunology

Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

scientific article published on June 2016

Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers

scientific article

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

scientific article published on 28 June 2019

Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway disease

scientific article published on 26 May 2020

Tripartite-motif proteins and innate immune regulation

scientific article published on 03 December 2010

Twenty-first century Foxp3

article by Anne O'Garra & Paulo Vieira published April 2003 in Nature Immunology

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling

scientific article

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

scientific article published on 04 November 2020

Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages

scientific article

Type I interferon dependence of plasmacytoid dendritic cell activation and migration.

scientific article

Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells.

scientific article published in March 2008

Type I interferons in infectious disease

scientific article

Type I interferons in tuberculosis: Foe and occasionally friend.

scientific article

Vaccination against tuberculosis: how can we better BCG?

scientific article published on 17 December 2012

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.

scientific article published on 16 April 2018

List of works by Anne O'Garra

A 380-gene meta-signature of active tuberculosis compared with healthy controls

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma

A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection.

A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

An interferon signature is associated with HAM/TSP but not viral containment in HTLV-1 infection

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis ⬇️

Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling

Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells

Are dendritic cells afraid of commitment?

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

Biological properties of interleukin 10

Biological properties of interleukin 10.

Biology and therapeutic potential of interleukin-10

Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection

Breakpoints in immunoregulation required for Th1 cells to induce diabetes

Brigitte Askonas (1923–2013) ⬇️

CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.

CD4+ T-cell subsets in autoimmunity

CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography

Checkpoints for regulation of development and IFN-gamma production by Th1 cells in TCR-transgenic models

Commit ye helpers

Commitment factors for T helper cells

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

Contribution of cytokines to pathology and protection in virus infection

Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei

Cytokine networking in lungs of immunocompetent mice in response to inhaled Aspergillus fumigatus

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets ⬇️

Cytokines and Ly-1 (B1) B cells

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice

Development and function of IL-10-secreting regulatory T cells: Comparison with naturally occurring CD4+CD25+ regulatory T cells

Development and function of T helper 1 cells

Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages

Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages

Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases

Differentiation of human TH-17 cells does require TGF-β!

Driving change in tuberculosis research: an interview with Anne O’Garra ⬇️

Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B

Editorial overview

Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

Erratum: Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

Establishing the Follicular Helper Identity

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation ⬇️

Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Further checkpoints in Th1 development

GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells.

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

Glycosylation-dependent modulation of the lL-2 signaling axis determines Th17 differentiation and IL-10 production

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations

High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17IL-10 Memory CD4 T Cell Response towards a Single IL-10-Producing Phenotype

Highlights of 10 years of immunology in Nature Reviews Immunology

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection

Identification of a macrophage-specific chromatin signature in the IL-10 locus.

Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas.

Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro

Immunology. Immunity benefits from a little suppression.

Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection

In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.