List of works - Elizabeth Ledgerwood

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

scientific article

A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus

scientific article

CYCS gene variants associated with thrombocytopenia

scientific article published on 19 November 2018

Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells

scientific article published on 01 June 2000

Comparison of the Molecular Forms of the Kex2/Subtilisin‐Like Serine Proteases SPC2, SPC3, and Furin in Neuroendocrine Secretory Vesicles Reveals Differences in Carboxyl‐Terminus Truncation and Membrane Association ⬇️

scientific article published on 01 November 1995

Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination

scientific article published on 19 January 2013

Congenital thrombocytopenia and cytochrome C mutation: a matter of birth and death

scientific article

Differentiation and cell density upregulate cytochrome c levels in megakaryoblastic cell lines: Implications for analysis of CYCS-associated thrombocytopenia

scientific article

Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease.

scientific article published on May 1995

Enhancing the peroxidase activity of cytochromecby mutation of residue 41: implications for the peroxidase mechanism and cytochromecrelease

scientific article published on 01 March 2014

Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c

scientific article

Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes

scientific article

Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells

scientific article published on September 2007

Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants

scientific article published on July 2005

Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis

scientific article published on 5 December 2007

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

scientific article published on 8 August 2012

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

scientific article published on 08 June 2010

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.

scientific article published on 27 February 2017

Targeting the apoptosome for cancer therapy

scientific article published on January 2009

The Imprinted Gene Peg3 Is Not Essential for Tumor Necrosis Factor α Signaling

article

The Proapoptotic G41S Mutation to Human Cytochrome c Alters the Heme Electronic Structure and Increases the Electron Self-Exchange Rate ⬇️

scientific article

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.

scientific article published on November 2009

The predicted proteinase furin is not the hepatic proalbumin convertase

scientific article published on 01 September 1992

The proportion of Met80-sulfoxide dictates peroxidase activity of human cytochrome c

scientific article published on 01 July 2018

The role of peroxiredoxin 1 in redox sensing and transducing

scientific article published on 15 October 2016

Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.

scientific article published on August 1999

Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II.

scientific article published on December 1998

Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.

scientific article published in December 2003

List of works by Elizabeth Ledgerwood

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus

CYCS gene variants associated with thrombocytopenia

Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells

Comparison of the Molecular Forms of the Kex2/Subtilisin‐Like Serine Proteases SPC2, SPC3, and Furin in Neuroendocrine Secretory Vesicles Reveals Differences in Carboxyl‐Terminus Truncation and Membrane Association ⬇️

Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination

Congenital thrombocytopenia and cytochrome C mutation: a matter of birth and death

Differentiation and cell density upregulate cytochrome c levels in megakaryoblastic cell lines: Implications for analysis of CYCS-associated thrombocytopenia

Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease.

Enhancing the peroxidase activity of cytochromecby mutation of residue 41: implications for the peroxidase mechanism and cytochromecrelease

Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c

Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes

Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells

Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants

Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.

Targeting the apoptosome for cancer therapy

The Imprinted Gene Peg3 Is Not Essential for Tumor Necrosis Factor α Signaling

The Proapoptotic G41S Mutation to Human Cytochrome c Alters the Heme Electronic Structure and Increases the Electron Self-Exchange Rate ⬇️

The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.

The predicted proteinase furin is not the hepatic proalbumin convertase

The proportion of Met80-sulfoxide dictates peroxidase activity of human cytochrome c

The role of peroxiredoxin 1 in redox sensing and transducing

Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.

Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II.

Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.