List of works - Michael G. Roth

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

scientific article (publication date: February 2009)

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

scientific article published on March 2000

Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.

scientific article published on February 1999

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

scientific article published in April 2007

Targeting QseC signaling and virulence for antibiotic development

scientific article

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

scientific article

Image-based genome-wide siRNA screen identifies selective autophagy factors

scientific article

A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin

scientific article published on August 1, 1991

Phosphoinositides in constitutive membrane traffic.

scientific article published in July 2004

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

scientific article published on 11 April 2018

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A

scientific article

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

scientific article

Mutations in the Middle of the Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells

scientific article published on July 13, 1998

Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.

scientific article

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

scientific article published on 01 May 1997

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

scientific article

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer

scientific article published on 24 October 2013

Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion

scientific article

ARNO and ARF6 Regulate Axonal Elongation and Branching through Downstream Activation of Phosphatidylinositol 4-Phosphate 5-Kinase α

scientific article published on October 17, 2003

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway

scientific article

Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts

scientific article published on November 17, 2003

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

scientific article

Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells.

scientific article published on October 1998

A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion.

scientific article

Molecular mechanisms of PLD function in membrane traffic.

scientific article published on 31 March 2008

Exo1: a new chemical inhibitor of the exocytic pathway

scientific article

PtK1 cells contain a nondiffusible, dominant factor that makes the Golgi apparatus resistant to brefeldin A

scientific article published on June 1, 1991

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

scientific article

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.

scientific article published on 28 September 2016

The role of lipid signaling in constitutive membrane traffic.

scientific article published on August 1997

Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma.

scientific article published on 25 October 2013

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

scientific article

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

scientific article published on 7 April 2013

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

scientific article

Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein

scientific article published in Nature

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

scientific article published on 7 September 2015

Tumor tracking and motion compensation with an adaptive tumor tracking system (ATTS): System description and prototype testing.

scientific article published on September 2008

Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic.

scientific article

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

scientific article published on 11 September 2011

H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia

scientific article published on August 14, 2012

Hierarchy of sorting signals in chimeras of intestinal lactase-phlorizin hydrolase and the influenza virus hemagglutinin.

scientific article published on March 1999

Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.

scientific article published on 05 July 2008

Features of influenza HA required for apical sorting differ from those required for association with DRMs or MAL.

scientific article published on December 2003

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized

scientific article

Apical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between mutant hemagglutinin proteins with different internalization signals.

scientific article

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

scientific article published on February 2012

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

scientific article published on August 25, 2014

Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation

scientific article published on 14 July 2014

Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans

scientific article

Casein kinase I regulates membrane binding by ARF GAP1.

scientific article

List of works by Michael G. Roth

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

Targeting QseC signaling and virulence for antibiotic development

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

Image-based genome-wide siRNA screen identifies selective autophagy factors

A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin

Phosphoinositides in constitutive membrane traffic.

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

Mutations in the Middle of the Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells

Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer

Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion

ARNO and ARF6 Regulate Axonal Elongation and Branching through Downstream Activation of Phosphatidylinositol 4-Phosphate 5-Kinase α

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway

Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells.

A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion.

Molecular mechanisms of PLD function in membrane traffic.

Exo1: a new chemical inhibitor of the exocytic pathway

PtK1 cells contain a nondiffusible, dominant factor that makes the Golgi apparatus resistant to brefeldin A

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.

The role of lipid signaling in constitutive membrane traffic.

Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma.

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

Tumor tracking and motion compensation with an adaptive tumor tracking system (ATTS): System description and prototype testing.

Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic.

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia

Hierarchy of sorting signals in chimeras of intestinal lactase-phlorizin hydrolase and the influenza virus hemagglutinin.

Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.

Features of influenza HA required for apical sorting differ from those required for association with DRMs or MAL.

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized

Apical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between mutant hemagglutinin proteins with different internalization signals.

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation

Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans

Casein kinase I regulates membrane binding by ARF GAP1.