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List of works by Merry L. Lindsey

A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis

scientific article

A conceptual cellular interaction model of left ventricular remodelling post-MI: dynamic network with exit-entry competition strategy

scientific article

ACE inhibitors to block MMP-9 activity: new functions for old inhibitors.

scientific article published on 12 September 2007

AMP activated protein kinase 2 protection during hypertension-induced hypertrophy: a common mediator in the signaling crossroads.

scientific article published on 6 October 2008

Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction

scientific article

Adding Reg3β to the acute coronary syndrome prognostic marker list

scientific article published on 01 May 2018

Age and SPARC change the extracellular matrix composition of the left ventricle

scientific article published on 24 March 2014

Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function

scientific article published on 13 December 2004

Aging modifies the cardiac response to estrogen: a new dimension to hormone replacement therapy

scientific article published on 28 August 2006

Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects.

scientific article

Alterations in Pulse Pressure Affect Artery Function.

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Alterations of pulse pressure stimulate arterial wall matrix remodeling

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Altered fibroblast function following myocardial infarction.

scientific article published in October 2005

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.

scientific article

Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction

scientific article published on 19 January 2017

Applications of miRNA technology for atherosclerosis.

scientific article

Artery buckling stimulates cell proliferation and NF-κB signaling

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Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling

scientific article published on 01 August 2018

Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation

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Bayesian parameter estimation for nonlinear modelling of biological pathways.

scientific article

Beta-blockade in heart failure: adding SENIORS to the mix

scientific article published on 27 January 2006

Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction.

scientific article

CC chemokine receptor 5 deletion impairs macrophage activation and induces adverse remodeling following myocardial infarction.

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CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling.

scientific article published on 17 November 2015

CD4<sup>+</sup> T Cell-Specific Proteomic Pathways Identified in Progression of Hypertension Across Postmenopausal Transition

scientific article published on 07 January 2021

Cardiac Fibroblast Activation Post-Myocardial Infarction: Current Knowledge Gaps

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Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction.

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Cardiac aging: Send in the vinculin reinforcements

scientific article published in June 2015

Cardiac assessment in pediatric mice: strain analysis as a diagnostic measurement

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Cardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics.

scientific article

Cardiac function of the naked mole-rat: ecophysiological responses to working underground

scientific article (publication date: March 2014)

Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

scientific article

Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle

scientific article published on January 2013

Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction.

scientific article

Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling.

scientific article published on 27 May 2011

Chronic <i>Porphyromonas gingivalis</i> lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8<sup>+</sup> T cells

scientific article published on 01 October 2021

Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses

scientific article

Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism.

scientific article published on 02 October 2013

Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle.

scientific article

Clinical and Translational Proteomics Focused on Tissue Damage, Repair, and Regeneration

scientific article published in January 2016

Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling ⬇️

scientific article

Crosstalk between cytotoxic T-lymphocyte associated antigen-4 and interleukin-12 in cytotoxic T-lymphocyte-mediated myocarditis: adding another link to the chain

scientific article published on 01 August 2007

Cytokines and the microcirculation in ischemia and reperfusion

scientific article published on 01 December 1998

DHA derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity ⬇️

scientific article published on June 24, 2012

Death of an antioxidant brings HFpEF to life: 5-oxoproline and post-ischemic cardio-renal dysfunction

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Defining the sham environment for post-myocardial infarction studies in mice

scientific article published on 12 August 2016

Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury

scientific article published on 27 December 2011

Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.

scientific article published on 14 February 2017

Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence.

scientific article published on 15 April 2015

Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution

scientific article

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

scientific article published on 13 October 2016

Effects of early and late chronic pressure overload on extracellular matrix remodeling

scientific article

Effects of surface-modified scaffolds on the growth and differentiation of mouse adipose-derived stromal cells.

scientific article published in May 2007

Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice.

scientific article published in September 2001

Estrogen effects on MMP-13 and MMP-14 regulation of left ventricular mass in Dahl salt-induced hypertension.

scientific article published in March 2008

Extracellular Matrix and Fibroblast Communication Following Myocardial Infarction ⬇️

scientific article published on August 28, 2012

Extracellular matrix in cardiovascular pathophysiology

scientific article published on 21 September 2018

Extracellular matrix proteomics in cardiac ischemia/reperfusion: the search is on.

scientific article published on 18 January 2012

Extracellular matrix remodeling following myocardial injury.

scientific article

Extracellular matrix roles during cardiac repair.

scientific article published on 27 July 2010

Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly

scientific article published on 25 August 2018

Extracellular matrix turnover and signaling during cardiac remodeling following MI: causes and consequences.

scientific article published on 25 June 2009

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis

scientific article published on 11 January 2019

Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice ⬇️

scientific article published on December 28, 2010

Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat.

scientific article published on 24 February 2012

Glucose regulates the intrinsic inflammatory response of the heart to surgically induced hypothermic ischemic arrest and reperfusion

scientific article published on 9 December 2016

Going out on a LIM and cysteine-rich domains 1 limb: a new way to block calcineurin activity.

scientific article published on 21 December 2009

Guidelines for Authors and Reviewers on Antibody Use in Physiology Studies.

scientific article published on 5 January 2018

Guidelines for Experimental Models of Myocardial Ischemia and Infarction

scientific article published on 12 January 2018

Guidelines for Measuring Cardiac Physiology in Mice

scientific article published on 5 January 2018

HDL-cholesterol levels and cardiovascular risk: acCETPing the context.

scientific article published on 28 October 2008

Harnessing the heart of big data

scientific article

Heart failure with preserved ejection fraction: emerging drug strategies

scientific article

Heart rate reduction: an old and novel candidate heart failure therapy.

scientific article published on 9 April 2012

Heavy hitting: Using water to label humans

scientific article

How to be an effective ally

scientific article published on 19 May 2024

IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation.

scientific article published on 24 April 2017

IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury

scientific article published on 01 September 2000

Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction

scientific article published on 20 September 2018

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium.

scientific article published on 03 May 2016

Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium.

scientific article published on February 1997

Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond.

scientific article published on January 2008

Integrative computational and experimental approaches to establish a post-myocardial infarction knowledge map.

scientific article

Intercellular adhesion molecule-1 regulation in the canine lung after cardiopulmonary bypass

scientific article published on 01 March 1998

Interleukin 6 induction in the canine myocardium after cardiopulmonary bypass

scientific article published on 01 August 2000

Introduction: Extracellular matrix and cardiovascular remodeling-using microscopy to delineate mechanisms.

scientific article

Is Isolated Systolic Hypertension Worse Than Combined Systolic/Diastolic Hypertension? ⬇️

scientific article published on October 9, 2012

Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction

scientific article

LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling

scientific article published on 21 August 2018

Left ventricular remodeling: one small step for the extracellular matrix will translate to a giant leap for the myocardium.

scientific article published on 25 January 2013

Long-lived ames dwarf mice are resistant to chemical stressors

scientific article

MMP induction and inhibition in myocardial infarction

scientific article published on January 2004

MMP-9 signaling in the left ventricle following myocardial infarction

scientific article published on 20 May 2016

Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction

scientific article

Macrophage roles following myocardial infarction

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Mapping macrophage polarization over the myocardial infarction time continuum.

scientific article published on 4 June 2018

Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction

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Mathematical modeling of left ventricular dimensional changes in mice during aging.

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Matrix Metalloproteinase-28 Deletion Exacerbates Cardiac Dysfunction and Rupture After Myocardial Infarction in Mice by Inhibiting M2 Macrophage Activation ⬇️

scientific article published on December 20, 2012

Matrix Metalloproteinases in Myocardial Infarction and Heart Failure.

scientific article published on 18 March 2017

Matrix Metalloproteinases: Drug Targets for Myocardial Infarction ⬇️

scientific article published on March 1, 2013

Matrix metalloproteinase (MMP)-7 activates MMP-8 but not MMP-13

scientific article published on 01 September 2006

Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation.

scientific article published on 3 April 2013

Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

scientific article published on 28 October 2018

Matrix metalloproteinase-28 deletion amplifies inflammatory and extracellular matrix responses to cardiac aging

scientific article

Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction

scientific article published on 12 June 2006

Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.

scientific article published on 26 August 2005

Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.

scientific article

Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling

scientific article published on 22 December 2015

Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion

scientific article published on 01 May 2001

Menopause and FOXP3+ Treg cell depletion eliminate female protection against T cell-mediated angiotensin II hypertension

scientific article published on 17 May 2019

Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts

scientific article

Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging.

scientific article

Myocardial Infarction Remodeling that Progresses to Heart Failure: A Signaling Misunderstanding

scientific article published on 30 March 2018

Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.

scientific article published on 15 April 2015

Myocardial matrix metalloproteinase-2: inside out and upside down.

scientific article

Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

scientific article

Negative elongation factor controls energy homeostasis in cardiomyocytes

scientific article published on 20 March 2014

Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues

scientific article published on 06 January 2021

Neutrophil proteome shifts over the myocardial infarction time continuum

scientific article published on 15 August 2019

Neutrophil roles in left ventricular remodeling following myocardial infarction.

scientific article published on 03 June 2013

Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction.

scientific article published on 27 July 2013

Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction

scientific article

Osteopontin is proteolytically processed by matrix metalloproteinase 9.

scientific article published on 26 March 2015

P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9

scientific article

Phagocytes in ischemia injury.

scientific article

Plasma Fractionation Enriches Post-Myocardial Infarction Samples Prior to Proteomics Analysis ⬇️

scientific article published on June 18, 2012

Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways

scientific article

Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy.

scientific article published in March 2005

Proteomic analysis identifies in vivo candidate matrix metalloproteinase-9 substrates in the left ventricle post-myocardial infarction.

scientific article published on June 2010

Proteomic analysis of the cardiac extracellular matrix: clinical research applications

scientific article

Proteomic analysis reveals late exercise effects on cardiac remodeling following myocardial infarction

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Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice.

scientific article published on 18 October 2013

Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion

scientific article published on 01 August 1998

Roles of saturated vs. polyunsaturated fat in heart failure survival: not all fats are created equal.

scientific article published on 8 November 2011

SPARC mediates early extracellular matrix remodeling following myocardial infarction.

scientific article

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.

scientific article published on 15 April 2015

Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.

scientific article published in February 2002

Stability analysis of genetic regulatory network with additive noises.

scientific article

Statistical considerations in reporting cardiovascular research

Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion

scientific article published on 01 August 1998

Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function

scientific article

Syndecan-4: a novel regulator of collagen synthesis and deposition in the pressure-overloaded myocardium.

scientific article published on 25 March 2015

Systems analysis of gene ontology and biological pathways involved in post-myocardial infarction responses.

scientific article published on 11 June 2015

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

scientific article published on July 2000

Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction.

scientific article published on 14 July 2010

Temporal clustering of gene expression patterns using short-time segments

Temporal clustering of gene expression patterns using short-time segments

Temporal neutrophil polarization following myocardial infarction

scientific article published on 29 January 2016

Texas 3-step decellularization protocol: looking at the cardiac extracellular matrix.

scientific article published on 14 May 2013

The Mouse Heart Attack Research Tool 1.0 database

scientific article published on 18 May 2018

The circular relationship between matrix metalloproteinase-9 and inflammation following myocardial infarction

scientific article (publication date: August 2015)

The compendium of matrix metalloproteinase expression in the left ventricle of mice following myocardial infarction

scientific article published on 21 February 2020

The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

scientific article published on 28 December 2015

The heart of physiological reports

scientific article published in March 2024

The history of matrix metalloproteinases: milestones, myths, and misperceptions ⬇️

scientific article published on August 17, 2012

The impact of aging on cardiac extracellular matrix.

scientific article published on 17 January 2017

The left ventricle proteome differentiates middle-aged and old left ventricles in mice

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The physics of an academic career

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The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure

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Thrombospondin-1: the good, the bad, and the complicated

scientific article published in December 2013

Tipping the extracellular matrix balance during heart failure progression: do we always go right?

scientific article published on 2 July 2010

Tissue Inhibitor of Metalloproteinase-1: Actions beyond Matrix Metalloproteinase Inhibition.

scientific article published on August 2015

Titin phosphorylation: myocardial passive stiffness regulated by the intracellular giant.

scientific article published on September 2009

Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice.

scientific article

Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association

scientific article (publication date: September 2015)

Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis.

scientific article published on 23 December 2016

Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction.

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Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulates

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Tumor necrosis factor-alpha--converting enzyme roles in hypertension-induced hypertrophy: look both ways when crossing the street.

scientific article published on 6 July 2009

Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes.

scientific article

Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

scientific article published on 01 December 2019

Understanding the role of the extracellular matrix in cardiovascular development and disease: where do we go from here?

scientific article published on 23 September 2009

Using an Investigative Journalism Approach to Design Mechanistic Experiments in Physiology

scientific article published on 01 July 2020

Using extracellular matrix proteomics to understand left ventricular remodeling

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Using plasma matrix metalloproteinase-9 and monocyte chemoattractant protein-1 to predict future cardiovascular events in subjects with carotid atherosclerosis

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Using proteomics to uncover extracellular matrix interactions during cardiac remodeling.

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Using systems biology approaches to understand cardiac inflammation and extracellular matrix remodeling in the setting of myocardial infarction

scientific article published on January 2014

Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent

scientific article published on January 2011

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

scientific article published on 16 June 2017

Women are different: the role of coupling factor 6 in blood pressure regulation

scientific article published on 02 February 2012

beta-blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction

scientific article published on 01 April 2000

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