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List of works by Simon J. Draper

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

scientific article

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys

scientific article

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

scientific article published on 26 April 2019

A new site of attack for a malaria vaccine

scientific article published in April 2018

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

article

A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose pre-exposure prophylaxis

A viral vectored prime-boost immunization regime targeting the malaria Pfs25 antigen induces transmission-blocking activity

scientific article (publication date: 2011)

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'.

scientific article published on 30 January 2017

Accelerating vaccine development and deployment: report of a Royal Society satellite meeting

scientific article published on October 2011

Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection

scientific article published on April 2014

Analysis of peripheral blood B and Tfh cells as predictors of antibody responses in individuals receiving candidate blood-stage malaria vaccines in a Phase Ia clinical trial.

scientific article published on 22 September 2014

Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominance

scientific article published in December 2005

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

scientific article published on 01 February 2020

Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Infections

article

Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure

article

Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome

scientific article published on 25 October 2013

Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure

scientific article

Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection

scientific article published on 4 January 2013

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

scientific article

Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines

scientific article published on 18 June 2013

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

scientific article published on 13 October 2016

Coated microneedle arrays for transcutaneous delivery of live virus vaccines

scientific article published on 29 December 2011

Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference

scientific article published on 29 August 2011

Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial

scientific article

Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum

scientific article published on 11 June 2015

Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection ⬇️

scientific article published on 09 April 2013

Controlled human blood stage malaria infection: current status and potential applications

scientific article published on April 2012

Controlled human malaria infection in Kenyan adults: A safe model that could accelerate assessment of novel drugs and vaccines in malaria endemic populations.

scientific article published on 22 September 2014

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

scientific article published in PLoS ONE

Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

scientific article published on 4 February 2016

Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5

scientific article published on 02 August 2019

Development of a Drosophila S2 insect-cell based placental malaria vaccine production process.

scientific article published on 4 December 2013

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

scientific article published on 11 June 2019

Effective induction of high-titer antibodies by viral vector vaccines

scientific article published on 27 July 2008

Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination

scientific article published on 26 July 2018

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens ⬇️

scientific article

Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines

scientific article published on 22 November 2010

Enhancing cellular immunogenicity of MVA-vectored vaccines by utilizing the F11L endogenous promoter

scientific article published on 23 November 2015

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

scientific article

Erratum: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article published in Nature Communications

Erythroferrone inhibits the induction of hepcidin by BMP6

scientific article published on 10 August 2018

Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

scientific article

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens.

scientific article published on 4 June 2019

Functional characterization and comparison of Plasmodium falciparum proteins as targets of transmission-blocking antibodies.

scientific article published on 31 October 2017

Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates

scientific article (publication date: 2012)

Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines.

scientific article published on 13 July 2016

Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL

scientific article published on 02 September 2019

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

scientific article published on September 2017

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

scientific article published on 13 June 2019

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.

scientific article

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

scientific article published on 2 November 2017

Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

scientific article published on 18 July 2013

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

scientific article

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

scholarly article

Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

scientific article

Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8 T Cell Responses

article

Investigation of IRES Insertion into the Genome of Recombinant MVA as a Translation Enhancer in the Context of Transcript Decapping

scientific article published on 26 May 2015

Kinetics of antibody responses to pfrh5-complex antigens in ghanaian children with plasmodium falciparum malaria

scientific article published on 8 June 2018

Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

scientific article published on 28 April 2015

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination

scientific article published on 11 March 2021

Malaria Vaccines: Moving Forward After Encouraging First Steps

scientific article published on March 2015

Malaria Vaccines: Recent Advances and New Horizons

scientific article published on 11 July 2018

Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

scientific article

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.

scientific article

New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1

scholarly article by Anna L. Goodman et al published 19 April 2011 in Infection and Immunity

New candidate vaccines against blood-stage Plasmodium falciparum malaria: prime-boost immunization regimens incorporating human and simian adenoviral vectors and poxviral vectors expressing an optimized antigen based on merozoite surface protein 1

scientific article

One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

scientific article published on 17 January 2017

Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

scientific article published on 23 August 2011

Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors

scientific article (publication date: 2012)

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo.

scientific article

Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure

scientific article published on 23 August 2017

Plasmodium vivax Controlled Human Malaria Infection - Progress and Prospects

scientific article

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

scientific article

Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax

scientific article

Prime-boost vectored malaria vaccines: progress and prospects

scientific article published on 18 January 2010

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

scientific article

Production, quality control, stability, and potency of cGMP-produced RH5.1 protein vaccine expressed in S2 cells

scientific article published on 17 August 2018

Progress with viral vectored malaria vaccines: A multi-stage approach involving "unnatural immunity".

scientific article

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

scientific article published on January 2013

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research.

scientific article published on 17 June 2019

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

scientific article published on 2 September 2024

Recent advances in antibody-inducing poxviral and adenoviral vectored vaccine delivery platforms for difficult disease targets

scientific article published on April 2013

Recent advances in recombinant protein-based malaria vaccines

scientific article

Recent developments in malaria vaccinology

scientific article published on 30 March 2015

Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1 Induce Antibody- and T Cell-Mediated Multistage Protection against Malaria

scientific article published on 16 March 2011

Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria

scientific article published on January 2009

Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection

scientific article

Requirement of fission yeast Cid14 in polyadenylation of rRNAs

scientific article published on March 2006

Role of Activins in Hepcidin Regulation during Malaria

scientific article published on 11 September 2017

SnoopLigase peptide-peptide conjugation enables modular vaccine assembly

scientific article published on 15 March 2019

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

scientific article

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody ⬇️

scientific article published on 27 May 2019

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

scientific article

Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein

scientific article

Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1.

scientific article

The PfRCR complex bridges malaria parasite and erythrocyte during invasion

scientific article published on 20 December 2023

The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site

scientific article published on 08 September 2020

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

scientific article

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

scientific article

The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus

scientific article

The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment

scientific article published on January 2013

Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans

scientific article published on 01 April 2019

Toward the development of effective transmission-blocking vaccines for malaria

scientific article

Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors

scientific article

Towards a multi-antigen multi-stage malaria vaccine.

scientific article published on 22 September 2014

Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1

scientific article (publication date: 2011)

Use of gene expression studies to investigate the human immunological response to malaria infection

scientific article published on 13 December 2019

Utilizing poxviral vectored vaccines for antibody induction-progress and prospects

scientific article published on 05 June 2013

Viruses as vaccine vectors for infectious diseases and cancer

scientific article published on January 2010

Workshop report: Malaria vaccine development in Europe--preparing for the future.

scientific article published on 30 September 2015

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