List of works by Jonathan Javitch

6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment

scientific article

A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice

scientific article published on 01 January 1998

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

scientific article published on 31 July 2006

A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

scientific article published in October 1994

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

scientific article

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

scientific article

A new mechanism of allostery in a G protein-coupled receptor dimer

scientific article (publication date: September 2014)

A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding.

scientific article

A role for information collection, management, and integration in structure-function studies of G-protein coupled receptors.

scientific article

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

scientific article published on 23 September 2013

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum.

scientific article published on 14 March 2018

Agonist-induced formation of unproductive receptor-G12 complexes

scientific article published on 17 August 2020

Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.

scientific article

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

scientific article

Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.

scientific article

Amphetamine induces dopamine efflux through a dopamine transporter channel.

scientific article

Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier.

scientific article published on 29 December 2003

Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation.

scientific article published on 19 March 2013

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

scientific article published on 21 April 2008

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

scientific article published on 17 August 2018

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

scientific article

Building a new conceptual framework for receptor heteromers

scientific article

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.

scientific article published in August 2006

Chloride binding site of neurotransmitter sodium symporters

scientific article published on 2 May 2013

Chloroethylclonidine and 2-Aminoethyl Methanethiosulfonate Recognize Two Different Conformations of the Human α2A-Adrenergic Receptor

scientific article published on 01 July 1999

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

scientific article

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290

scientific article published on 29 July 2016

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

scientific article

Conformational dynamics of ligand-dependent alternating access in LeuT.

scientific article

Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

scientific article published on 01 July 1997

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

scientific article published on 01 September 2021

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

scientific article published on 01 June 2014

Crystal structure of a potassium ion transporter, TrkH

scientific article

Crystal structures of LeuT reveal conformational dynamics in the outward-facing states

scientific article published on 01 January 2021

Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function.

scientific article published on January 2008

D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism.

scientific article published on 31 January 2007

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum

scientific article published on August 2011

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

scientific article (publication date: 2016)

Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits Gs and Golf.

scientific article published on 17 October 2017

Differential visualization of dopamine D2 and D3 receptors in rat brain.

scientific article

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor

scientific article

Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening

scientific article

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing

scientific article published on 20 October 2021

Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization.

scientific article published on September 2017

Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage?

scientific article published on 27 May 2003

Dopamine receptor activation increases HIV entry into primary human macrophages

scientific article

Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism.

scientific article

Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro

scientific article

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling

scientific article published on 23 February 2015

Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder

scientific article

Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging.

scientific article published on 07 September 2016

Electrostatic and aromatic microdomains within the binding-site crevice of the D2 receptor: contributions of the second membrane-spanning segment.

scientific article published on June 1999

Evidence against dopamine D1/D2 receptor heteromers

scientific article

Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse

scientific article

Experimental conditions can obscure the second high-affinity site in LeuT.

scientific article published on 15 January 2012

Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor.

scientific article published on 27 July 2010

Expression and characterization of human dopamine D2 receptor in baculovirus-infected insect cells.

scientific article published on February 1994

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

scientific article published on 2 October 2017

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

scientific article

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

scientific article

G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation

scientific article

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.

scientific article published on 30 March 2009

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

scientific article published on 10 August 2020

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

scientific article

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists.

scientific article published on 15 September 2009

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.

scientific article published on 23 July 2015

High-Throughput Screening for Modulators of the D2 Dopamine Receptor Yields Unique and Selective Pharmacological Chemotypes

scholarly article published 2014

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

scientific article published on 3 November 2003

Identification of novel functionally selective κ-opioid receptor scaffolds

scientific article

Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers.

scientific article

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

scientific article published on March 2007

Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.

scientific article

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB.

scientific article published on 14 October 2016

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

scientific article

Making structural sense of dimerization interfaces of delta opioid receptor homodimers

scientific article

Mechanism of chloride interaction with neurotransmitter:sodium symporters.

scientific article

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

scientific article published on 13 April 2015

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

scientific article

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

scholarly article by Chadi Abdallah et al published July 2017 in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

scientific article

Monitoring the function of membrane transport proteins in detergent-solubilized form

scholarly article

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor

scientific article

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.

scientific article published on 2 December 2002

Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.

scientific article

Normal MPTP binding in parkinsonian substantial nigra: evidence for extraneuronal toxin conversion in human brain

scientific article published in April 1985

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

scientific article published on April 2016

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

scientific article published on 22 November 2017

PI 3-kinase regulation of dopamine uptake.

scientific article

PI3K signaling supports amphetamine-induced dopamine efflux.

scientific article published on 27 May 2008

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.

scientific article

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3.

scientific article published on 5 December 2011

Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter

scientific article published on 29 May 2017

Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications for Amphetamine Action.

scientific article published on 25 October 2017

Potentiating SLC transporter activity: Emerging drug discovery opportunities.

scientific article published on 15 February 2017

Probing conformational changes in neurotransmitter transporters: a structural context

scientific article published on October 2003

Probing structure of neurotransmitter transporters by substituted-cysteine accessibility method

scientific article published on 01 January 1998

Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

scientific article published on 17 August 2020

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter.

scientific article

Rebuttal from Nevin A. Lambert and Jonathan A. Javitch

Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.

scientific article

Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.

scientific article

Regulation of dopamine transporter trafficking by intracellular amphetamine

scientific article published on 09 May 2006

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

scientific article

Residues in the fifth membrane-spanning segment of the dopamine D2 receptor exposed in the binding-site crevice.

scientific article

Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.

scientific article published on September 1996

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

scientific article published on 01 April 2020

Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action

scientific article

Segregation of family A G protein-coupled receptor protomers in the plasma membrane

scientific article

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

scientific article published on 25 June 2010

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

scientific article published on 07 June 2017

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

scientific article

Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking

scientific article published on February 2004

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum.

scientific article published on 23 June 2006

Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2

scientific article

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

scientific article

Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters

scientific article

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

scientific article

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

scientific article

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

scientific article published on August 2004

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

scientific article published in May 2004

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux

scientific article

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

scientific article

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

scientific article

The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila

scientific article published on 25 February 2021

The ants go marching two by two: oligomeric structure of G-protein-coupled receptors.

scientific article published on 19 August 2004

The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist

scientific article (publication date: 15 July 2014)

The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

scientific article published on December 2000

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

scientific article

The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle

scientific journal article

The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila.

scientific article published on 19 June 2012

The role of kinetic context in apparent biased agonism at GPCRs

scientific article published on 24 February 2016

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

scientific article published on 20 March 2017

The substituted-cysteine accessibility method (SCAM) to elucidate membrane protein structure.

scientific article

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter

scientific article

The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors

scientific article

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

scientific article

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor

scientific article

Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

scientific article

Treatment resistant depression: A multi-scale, systems biology approach

scientific article

Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores

scientific article published on 10 September 2020

Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin

scientific article (publication date: 15 August 2009)

Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

scientific article published on 12 January 2015

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP.

scientific article published in November 1984

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

scientific article

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors

scientific article published on September 2015

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

scientific article

Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes ⬇️

scientific article

Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.

scientific article

[3H]MFZ 2-12: a novel radioligand for the dopamine transporter.

scientific article

[3H]mazindol binding associated with neuronal dopamine uptake sites in corpus striatum membranes

scientific article

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