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List of works by Brinton Seashore-Ludlow

A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.

scientific article

A general enantioselective route to the chamigrene natural product family

scientific article published on March 2010

Asymmetric transfer hydrogenation coupled with dynamic kinetic resolution in water: synthesis of anti-β-hydroxy-α-amino acid derivatives

scientific article published on 10 December 2012

Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines

scientific article published on 01 January 2019

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

scientific article

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

scientific article

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

scientific article published on 24 March 2016

Discovery of a Small-Molecule Probe for V-ATPase Function

scientific article published on 20 April 2015

Domino carbopalladation-carbonylation: generating quaternary stereocenters while controlling beta-hydride elimination

scientific article published on 01 September 2010

Domino carbopalladation-cross-coupling for the synthesis of 3,3-disubstituted oxindoles

scientific article published on 17 July 2012

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

scientific article

Early Perspective

scientific article published on 11 July 2016

Enantioselective synthesis of anti-β-hydroxy-α-amido esters by asymmetric transfer hydrogenation in emulsions

scientific article published on 24 April 2012

Enantioselective synthesis of anti-β-hydroxy-α-amido esters via transfer hydrogenation

scientific article published on 21 October 2010

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

scientific article published on 22 March 2019

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

scientific article

In Situ Target Engagement Studies in Adherent Cells

scientific article published on 12 February 2018

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis

scientific article

NAMPT is the cellular target of STF-31-like small-molecule probes

scientific article published on 7 August 2014

Perspective on CETSA Literature: Toward More Quantitative Data Interpretation

scientific article published on 30 October 2019

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality

scientific article

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

scientific article

Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay

scientific article published on 19 November 2018

Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth

scientific article published on 23 March 2018

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

scientific article published on 06 July 2020

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

scientific article published on 14 August 2017

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

scientific article published on 5 March 2018

Using High Content Imaging to Quantify Target Engagement in Adherent Cells

scientific article published on 29 November 2018

Validation and development of MTH1 inhibitors for treatment of cancer.

scientific article

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