List of works - Andreas Matouschek

A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains

scientific article published on 04 March 2016

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB

article

A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

scientific article published on 24 April 2020

A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

scientific article published on 15 September 2011

ATP-Dependent Proteases: The Cell's Degradation Machines

ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal

scientific article published in March 2001

ATP-dependent proteases differ substantially in their ability to unfold globular proteins

scientific article published on 21 April 2009

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

scientific article

An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors

scientific article

An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates

scientific article published on 10 June 2016

An unstructured initiation site is required for efficient proteasome-mediated degradation

scientific article

Cell biology. An ancient portal to proteolysis

scientific article published on August 2012

Chance, destiny, and the inner workings of ClpXP.

scientific article published on July 2014

Concurrent translocation of multiple polypeptide chains through the proteasomal degradation channel

scientific article

Controlling a single protein in a nanopore through electrostatic traps

scientific article published on 6 March 2008

Correction to disordered proteinaceous machines

scientific article published on 26 March 2015

Cyclophilin catalyzes protein folding in yeast mitochondria

scientific article

Decoding without the cipher

scientific article published on 01 March 2019

Defining the geometry of the two-component proteasome degron

scientific article

Disordered proteinaceous machines

scientific article

Effect of protein structure on mitochondrial import.

scientific article

Effect of the protein import machinery at the mitochondrial surface on precursor stability

scientific article

Erratum: Targeting proteins for degradation

scholarly article published in Nature Chemical Biology

Erratum: Where to start and when to stop

scholarly article published in Nature Structural & Molecular Biology

Finding a protein's Achilles heel

scientific article published in September 2003

How ClpX unfolds GFP in stages by pulling

scientific article published on 6 August 2011

How to pick a protein and pull at it.

scientific article

Inefficient degradation of truncated polyglutamine proteins by the proteasome

scientific article published on 07 October 2004

Intrinsically disordered segments affect protein half-life in the cell and during evolution

scientific article

Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH.

scientific article

Making it easier to regulate protein stability

scientific article published on September 2010

Mechanical unfolding of spectrin reveals a super-exponential dependence of unfolding rate on force

scientific article published on 31 July 2019

Mitochondria Unfold Precursor Proteins by Unraveling Them From Their N-termini

scientific article

Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation

scientific article published on 28 March 2017

Paradigms of protein degradation by the proteasome

scientific article

Physical-organic molecular biology: pathway and stability of protein folding

scholarly article by A. R. Fersht published in January 1991

Proteasomal Degradation from Internal Sites Favors Partial Proteolysis via Remote Domain Stabilization ⬇️

scientific article published on August 12, 2011

Protein Unfolding in the Cell

Protein targeting to ATP-dependent proteases

scientific article published on 13 February 2008

Protein unfolding by the mitochondrial membrane potential

scientific article published in April 2002

Protein unfolding in the cell

scientific article published in November 2004

Protein unfolding--an important process in vivo?

scientific article

Pup grows up: in vitro characterization of the degradation of pupylated proteins

scientific article

Rad23 escapes degradation because it lacks a proteasome initiation region

scientific article

Ramping up degradation for proliferation

scientific article published in February 2016

Recognition of Client Proteins by the Proteasome.

scientific article published on 9 March 2017

Regulated protein turnover: snapshots of the proteasome in action

scientific article

Regulation of Proteasomal Degradation by Modulating Proteasomal Initiation Regions

scientific article published on 17 August 2015

Scalable In Vitro Proteasome Activity Assay

scientific article published on 01 January 2018

Sequence composition of disordered regions fine-tunes protein half-life

scientific article

Sequence- and species-dependence of proteasomal processivity

scientific article

Substrate selection by the proteasome during degradation of protein complexes

scientific article

Substrate selection by the proteasome through initiation regions

scientific article published on 23 May 2019

Targeting proteins for degradation

scientific article

The Structure of Precursor Proteins during Import into Mitochondria

scientific article published in Journal of Biological Chemistry

The dimensions of the protein import channels in the outer and inner mitochondrial membranes

scientific article published on November 1999

The force exerted by the membrane potential during protein import into the mitochondrial matrix

scientific article

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

scientific article published on 24 January 2020

To degrade or release: ubiquitin-chain remodeling

scientific article published on 27 September 2007

Top-down 193-nm ultraviolet photodissociation mass spectrometry for simultaneous determination of polyubiquitin chain length and topology

scientific article

Transient folding intermediates characterized by protein engineering

scientific article

Ubiquitin-like domains can target to the proteasome but proteolysis requires a disordered region

scientific article published on 27 May 2016

Use of Multiple Ion Fragmentation Methods to Identify Protein Cross-Links and Facilitate Comparison of Data Interpretation Algorithms

scientific article published on 04 June 2020

Where to start and when to stop

article by Lin Tian & Andreas Matouschek published August 2006 in Nature Structural & Molecular Biology

beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein

scientific article

List of works by Andreas Matouschek

A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB

A masked initiation region in retinoblastoma protein regulates its proteasomal degradation

A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

ATP-Dependent Proteases: The Cell's Degradation Machines

ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal

ATP-dependent proteases differ substantially in their ability to unfold globular proteins

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors

An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates

An unstructured initiation site is required for efficient proteasome-mediated degradation

Cell biology. An ancient portal to proteolysis

Chance, destiny, and the inner workings of ClpXP.

Concurrent translocation of multiple polypeptide chains through the proteasomal degradation channel

Controlling a single protein in a nanopore through electrostatic traps

Correction to disordered proteinaceous machines

Cyclophilin catalyzes protein folding in yeast mitochondria

Decoding without the cipher

Defining the geometry of the two-component proteasome degron

Disordered proteinaceous machines

Effect of protein structure on mitochondrial import.

Effect of the protein import machinery at the mitochondrial surface on precursor stability

Erratum: Targeting proteins for degradation

Erratum: Where to start and when to stop

Finding a protein's Achilles heel

How ClpX unfolds GFP in stages by pulling

How to pick a protein and pull at it.

Inefficient degradation of truncated polyglutamine proteins by the proteasome

Intrinsically disordered segments affect protein half-life in the cell and during evolution

Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH.

Making it easier to regulate protein stability

Mechanical unfolding of spectrin reveals a super-exponential dependence of unfolding rate on force

Mitochondria Unfold Precursor Proteins by Unraveling Them From Their N-termini

Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation

Paradigms of protein degradation by the proteasome

Physical-organic molecular biology: pathway and stability of protein folding

Proteasomal Degradation from Internal Sites Favors Partial Proteolysis via Remote Domain Stabilization ⬇️

Protein Unfolding in the Cell

Protein targeting to ATP-dependent proteases

Protein unfolding by the mitochondrial membrane potential

Protein unfolding in the cell

Protein unfolding--an important process in vivo?

Pup grows up: in vitro characterization of the degradation of pupylated proteins

Rad23 escapes degradation because it lacks a proteasome initiation region

Ramping up degradation for proliferation

Recognition of Client Proteins by the Proteasome.

Regulated protein turnover: snapshots of the proteasome in action

Regulation of Proteasomal Degradation by Modulating Proteasomal Initiation Regions

Scalable In Vitro Proteasome Activity Assay

Sequence composition of disordered regions fine-tunes protein half-life

Sequence- and species-dependence of proteasomal processivity

Substrate selection by the proteasome during degradation of protein complexes

Substrate selection by the proteasome through initiation regions

Targeting proteins for degradation

The Structure of Precursor Proteins during Import into Mitochondria

The dimensions of the protein import channels in the outer and inner mitochondrial membranes

The force exerted by the membrane potential during protein import into the mitochondrial matrix

The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

To degrade or release: ubiquitin-chain remodeling

Top-down 193-nm ultraviolet photodissociation mass spectrometry for simultaneous determination of polyubiquitin chain length and topology

Transient folding intermediates characterized by protein engineering

Ubiquitin-like domains can target to the proteasome but proteolysis requires a disordered region

Use of Multiple Ion Fragmentation Methods to Identify Protein Cross-Links and Facilitate Comparison of Data Interpretation Algorithms

Where to start and when to stop

beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein