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List of works by Eugene Valkov

1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex

scientific article published on 23 September 2015

A Molecular Mechanism for Bacterial Susceptibility to Zinc

scientific article

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

scientific article

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay

scientific article published on 01 September 2019

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.

scientific article published on 28 September 2013

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

scientific article

Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM.

scientific article published on 26 November 2011

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

scientific article

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6.

scientific article

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

scientific article

Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos

scientific article

Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface

scientific article

Functional and structural characterization of the integrase from the prototype foamy virus

scientific article

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

scientific article

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

scientific article published on 04 January 2021

Improved molecular replacement by density- and energy-guided protein structure optimization

scientific article (publication date: 26 May 2011)

Mechanism of Bacterial Interference with TLR4 Signaling by Brucella Toll/Interleukin-1 Receptor Domain-containing Protein TcpB

scientific article

Mille viae in eukaryotic mRNA decapping

scientific article published on 4 June 2017

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

scientific article published on 09 December 2021

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling

scientific article published on 13 October 2014

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

scientific article published on 18 July 2019

Retroviral intasome assembly and inhibition of DNA strand transfer

scientific article

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design

scientific article published on 20 April 2015

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase

scientific article published on 25 March 2015

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.

scientific article published on 4 June 2015

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

scientific article

Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester

scientific article published on 16 February 2018

Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex

scientific article published on 24 October 2018

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

scientific article

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export

scientific article

Structural basis for the assembly and disassembly of mRNA nuclear export complexes

scientific article published on 02 March 2012

Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers

scientific article

Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum

scientific article

Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast

scientific article published on 01 July 2018

Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation

scientific article

Targeting protein-protein interactions and fragment-based drug discovery.

scientific article

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation

scientific article published on 19 October 2016

The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA

scientific article published on 27 January 2015

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

scientific article published on 01 February 2020

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins

scientific article

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