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List of works by Giuseppe Lembo

'Alzheimer-like' pathology in a murine model of arterial hypertension.

scientific article

A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

scientific article published on 27 September 2016

A lesson from polycystic ovarian syndrome: untangling the role of renal sympathetic nervous system on hypertension and insulin resistance

scientific article published on 01 May 2011

A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors.

scientific article

Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists.

scientific article published in April 2005

Antihypertensive efficacy and safety of manidipine versus amlodipine in elderly subjects with isolated systolic hypertension: MAISH study

scientific article published on 01 January 2007

Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension.

scientific article published on 27 July 2007

Cardiac effects of atrial natriuretic peptide in subjects with normal left ventricular function

scientific article published in February 1989

Cardiac function in systemic hypertension before and after reversal of left ventricular hypertrophy

scientific article published in October 1988

Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.

scientific article published on 28 April 2005

Cardiopulmonary receptors and coronary circulation.

scientific article published in July 1990

Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.

scientific article

Characterization of Nitric Oxide Release by Nebivolol and Its Metabolites

scientific article published on 01 June 2006

Chronic Type A aortic dissection: could surgical intervention be guided by molecular markers?

scientific article published on July 2011

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive

scientific article published on 18 November 2014

Cooperation between insulin and leptin in the modulation of vascular tone.

scientific article published on 30 June 2003

DOCA-salt hypertension activates PlGF in the spleen to couple sympathetic drive and immune system activation

scientific article published on 8 January 2018

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

scientific article published on 17 January 2011

Effect of complete cardiac denervation on atrial natriuretic factor release in baboons.

scientific article

Effects of celiprolol on systemic and forearm circulation in hypertensive patients: a double-blind cross-over study versus metoprolol

scientific article published on 01 August 1987

Efficacy of once-daily urapidil treatment in mild or moderate essential hypertension assessed by ambulatory 24-hour blood pressure monitoring

scientific article published on 01 January 1988

Emilin1 links TGF-beta maturation to blood pressure homeostasis

scientific article

Erythrocyte-derived depressing factor: a novel cardiovascular player?

scientific article published on 01 June 2003

Evaluation of microvascular structure in humans: a 'state-of-the-art' document of the Working Group on Macrovascular and Microvascular Alterations of the Italian Society of Arterial Hypertension

scientific article

Fatty acids are the best fuel for overloaded hearts

scientific article published on 01 July 2018

Flavanol-rich cocoa at breakfast: the right remedy after a sleepless night to prevent negative effects on blood pressure and cognition?

scientific article published on July 2016

From clinical observations to molecular mechanisms and back to patients: the successful circuit of the CANTOS study

scientific article published on 01 January 2018

G-Protein-Coupled Receptor Kinases in Hypertension ⬇️

scientific article published on March 1, 2013

Heart, Spleen, Brain

scientific article published on 01 October 2018

Hemorrhagic transformation of acute ischemic stroke is limited in hypertensive patients with cardiac hypertrophy

scientific article

Hypertension Induces Brain β-Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature ⬇️

scientific article published on May 21, 2012

Hypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental Relationship

scientific article

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

scientific article published on 14 April 2011

Identification of a brainstem locus that inhibits tumor necrosis factor

scientific article published on 09 November 2020

Immunological Aspects of Hypertension.

scientific article published on 14 April 2016

Increased basal nitric oxide release despite enhanced free radical production in hypertension.

scientific article published in June 2002

Infliximab in the treatment of extra-intestinal manifestations of Crohn's disease.

scientific article published in September 2005

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

scientific article published on April 2011

Integrin signalling: the tug-of-war in heart hypertrophy.

scientific article

Ischaemic stroke following tranexamic acid in young patients carrying heterozygosity of MTHFR C677T.

scientific article

Lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats

scientific article

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

scientific article published on 16 April 2015

Left ventricular hypertrophy is associated with asymptomatic cerebral damage in hypertensive patients.

scientific article

Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans

scientific article published on 01 October 2018

Mechanisms of cardiac hypertrophy.

scientific article published on July 2005

Mechanisms of soluble beta-amyloid impairment of endothelial function

scientific article

Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients

scientific article

MiR-153/Kv7.4: a novel molecular axis in the regulation of hypertension

scientific article published on 01 November 2016

Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs

scientific journal article

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation.

scientific article published on 30 July 2007

Nitric oxide mechanisms of nebivolol.

scientific article published on 14 May 2009

Nitroxyl (HNO) for treatment of acute heart failure

scientific article published on September 2014

PI3Kinases in Diabetes Mellitus and Its Related Complications ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2018

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

article

PI3Kγ in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage

scientific article

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism

scientific article published on 27 October 2011

Pathophysiological Links Among Hypertension and Alzheimer's Disease

scientific article published on 09 June 2015

Placental Growth Factor Regulates Cardiac Inflammation Through the Tissue Inhibitor of Metalloproteinases-3/Tumor Necrosis Factor-α–Converting Enzyme Axis

scientific article published on 06 September 2011

Placental growth factor and cardiac inflammation.

scientific article published on 25 August 2012

Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

scientific article published on 21 September 2009

Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.

scientific article

Reflex control of coronary vascular tone by cardiopulmonary receptors in humans.

scientific article

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

scientific article

Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice

scientific article

Resistin impairs insulin-evoked vasodilation.

scientific article

Role of neuroinflammation in hypertension-induced brain amyloid pathology

scientific article

Signaling pathways for cardiac growth and hypertrophy. Recent advances and prospects for growth factor therapy.

scientific article published on March 1995

Stable improvement in large artery compliance after long-term antihypertensive treatment with enalapril.

scientific article

Sympathetic deactivation by growth hormone treatment in patients with dilated cardiomyopathy

scientific article published on 01 April 1998

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

scientific article

Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling.

scientific article published on 10 November 2017

The Angiogenic Factor PlGF Mediates a Neuroimmune Interaction in the Spleen to Allow the Onset of Hypertension

scientific article published on 07 November 2014

The Interactions of the Immune System and the Brain in Hypertension.

scientific article published on 24 February 2018

The Multifaceted Roles of PI3Kγ in Hypertension, Vascular Biology, and Inflammation

scientific article

The Spleen: A Hub Connecting Nervous and Immune Systems in Cardiovascular and Metabolic Diseases

scientific article

Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage.

scientific article published on 26 May 2009

Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure

scientific article published on 19 July 2012

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