List of works - Marcelo N. Muscara

A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.

scientific article published on February 2002

A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis.

scientific article published on 16 November 2013

A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline

scientific article published on 02 January 2012

A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug

scientific article published on 11 April 2019

Abdominal hyperalgesia in secretory phospholipase A2-induced rat pancreatitis: distinct roles of NK1 receptors

scientific article published on 11 May 2011

Acid suppression by omeprazole does not affect orally administered metronidazole bioavailability and metabolism in healthy male volunteers

scientific article published on 01 April 1998

Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test

scientific article published in March 1997

Acute pulmonary inflammation induced by exposure of the airways to staphylococcal enterotoxin type B in rats

scientific article published on 14 July 2006

An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption.

scientific article published on 22 September 2008

Anti-inflammatory activity of crude extract and fractions of Nectandra falcifolia leaves

scientific article published on 01 November 2006

Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease

scientific article published on 28 December 2013

Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models

scientific article published on 17 April 2013

Bioavailability of four pharmaceutical formulations of metronidazole tested on normal healthy volunteers

scientific article published on January 1, 1991

Bioequivalence study of two enalapril maleate tablet formulations in healthy male volunteers Pharmacokinetic versus pharmacodynamic approach

scientific article published on 01 January 1996

Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.

scientific article published in October 2001

COX-inhibiting nitric oxide donors (CINODs): potential benefits on cardiovascular and renal function

scientific article (publication date: April 2006)

Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism.

scientific article

Comparative bioavailability of two atenolol tablet formulations in healthy male volunteers after a single dose administration

scientific article published on August 1, 1997

Conversion of immunosuppressive monotherapy from cyclosporin a to tacrolimus reverses bone loss in rats

scientific article published on 06 July 2007

Daily cycling of nitric oxide synthase (NOS) in the hippocampus of pigeons (C. livia)

scientific article

Early postnatal, but not late, exposure to chemical ambient pollutant 1,2-naphthoquinone increases susceptibility to pulmonary allergic inflammation at adulthood.

scientific article

Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.

scientific article published on January 1998

Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro

scientific article published on 01 May 1994

Effects of Selective Versus Non-Selective COX-2 Inhibition on Experimental Periodontitis

scientific article published on 01 March 2019

Effects of neonatal capsaicin treatment in the neutrophil production, and expression of preprotachykinin-I and tachykinin receptors in the rat bone marrow

scientific article published on 07 September 2006

Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 1: morphological and functional aspects

scientific article published on 5 October 2017

Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 2: biochemical aspects.

scientific article published on 9 August 2017

Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus.

scientific article published on 3 May 2009

Elucidating the role of oxidative stress in the therapeutic effect of rutin on experimental acute pancreatitis

scientific article published on 13 October 2016

Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products

scientific article published on 4 December 2015

Endothelin receptor antagonists: another potential alternative for cardiovascular diseases.

scientific article

Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats

scientific article published on 01 September 1999

Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.

scientific article published in February 2002

Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide

scientific article published on 29 June 2015

Gastric mucosal mast cells in atopic subjects

scientific article published on 01 April 1995

Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl est

scientific article published on 30 January 2004

H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreventative potential

scientific article

Hydrogen Sulfide: An Endogenous Mediator of Resolution of Inflammation and Injury ⬇️

scientific article published on December 15, 2011

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

scientific article

Hydrogen sulfide and dermatological diseases

scientific article published on 18 June 2019

Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice.

scientific article

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

scientific article published on 01 January 1999

In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1.

scientific article

In vivo inhibition of nitric oxide synthesis does not depend on renin-angiotensin system activation.

scientific article published in December 1996

Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation.

scientific article published on 14 July 2016

Inflammatory mechanisms underlying the rat pulmonary neutrophil influx induced by airway exposure to staphylococcal enterotoxin type A.

scientific article published in November 2005

Influence of antiplatelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats

scientific article published on 12 November 2010

Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit

scientific article (publication date: March 2002)

Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.

scientific article

Intermittent therapy with 1,25 vitamin D and calcitonin prevents cyclosporin-induced alveolar bone loss in rats.

scientific article published on 5 June 2010

Intracellular mechanisms of hydroquinone toxicity on endotoxin-activated neutrophils.

scientific article published on 21 June 2012

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

scientific article published on 31 October 2017

Laser photobiomodulation of pro-inflammatory mediators on Walker Tumor 256 induced rats.

scientific article

Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats.

scientific article

Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity

scientific article published on 25 February 2008

Lymphatic-borne IL-1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal ischema/reperfusion in rats

scientific article published on 01 December 2007

Mechanisms involved in the enhancement of allergic airways neutrophil influx by permanent C-fiber degeneration in rats

scientific article published on 3 December 2004

Mesenchymal Stromal Cell-Derived Microvesicles Regulate an Internal Pro-Inflammatory Program in Activated Macrophages

scientific article published on 31 July 2017

MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages.

scientific article

Myeloperoxidase as Inflammatory Marker of Periodontal Disease: Experimental Study in Rats

scientific article published on 01 January 2009

Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?

scientific article published on 04 January 2011

Nitric oxide modulates lipopolysaccharide-induced endothelial platelet endothelial cell adhesion molecule expression via interleukin-10.

scientific article published on 12 May 2011

Nitric oxide synthase inhibitor influences prostaglandin and interleukin-1 production in experimental arthritic joints

scientific article published in February 1997

Oral administration of antioxidants improves skin wound healing in diabetic mice

scientific article published on 29 September 2016

PAR(2) and temporomandibular joint inflammation in the rat.

scientific article published on 22 July 2010

Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.

scientific article

Peripheral blood mononuclear phagocytes from patients with chronic periodontitis are primed for osteoclast formation.

scientific article

Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats

scientific article

Plasma hydroxy metronidazole/metronidazole ratio in anti-HCV carriers with and without apparent liver disease

scientific article

Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury

scientific article published on 01 October 1999

Platelet-rich plasma stimulates cytokine expression and alkaline phosphatase activity in osteoblast-derived osteosarcoma cells

scientific article

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice.

scientific article published on 10 November 2016

Quantification of methyldopa in human plasma by high-performance liquid chromatography-electrospray tandem mass spectrometry application to a bioequivalence study.

scientific article published in March 2002

Quantification of nimesulide in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Application to bioequivalence studies.

scientific article published in December 2001

Reduction of inflammation in rats by diazepam: tolerance development.

scientific article published in April 2003

Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus

scientific article published on 7 April 2011

Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions

scientific article

Role of transient receptor potential vanilloid 4 in rat joint inflammation

scientific article published on 19 December 2011

Selective cyclo-oxygenase-2 inhibitors: cardiovascular and gastrointestinal toxicity

scientific article (publication date: December 2001)

Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: participation of endostatin and vascular endothelial growth factor.

scientific article

Simultaneous determination of nitrite and nitrate anions in plasma, urine and cell culture supernatants by high-performance liquid chromatography with post-column reactions

article

Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats.

scientific article

Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase

scientific article published on 17 October 2012

TRPV1 antagonism by capsazepine modulates innate immune response in mice infected with Plasmodium berghei ANKA.

scientific article published on 24 August 2014

Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.

scientific article

The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis.

scientific article

The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages

scientific article published on 20 September 2017

The long-term administration of calcineurin inhibitors decreases antioxidant enzyme activity in the rat parotid and submandibular salivary glands.

scientific article published on 23 May 2015

The release of nitric oxide and superoxide anion by neutrophils and mononuclear cells from patients with sickle cell anaemia

scientific article published on 01 May 1996

The renin-angiotensin system plays a major role in voiding dysfunction of ovariectomized rats.

scientific article published on 16 September 2013

Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity

scientific article published on 7 February 2013

Upregulation of gp91phox subunit of NAD(P)H oxidase contributes to erectile dysfunction caused by long-term nitric oxide inhibition in rats: reversion by regular physical training.

scientific article published on 4 December 2009

Upregulation of muscarinic receptors by long-term nitric oxide inhibition in the rat ileum.

scientific article published in March 2003

Vasoactive peptides in cardiovascular (patho)physiology.

scientific article published on May 2007

iNOS‐Derived Nitric Oxide Stimulates Osteoclast Activity and Alveolar Bone Loss in Ligature‐Induced Periodontitis in Rats ⬇️

scientific article published on March 21, 2011

mRNA and protein expression and activities of nitric oxide synthases in the lumbar spinal cord of neonatal rats after sciatic nerve transection and melatonin administration

scientific article published on 15 September 2006

List of works by Marcelo N. Muscara

A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.

A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis.

A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline

A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug

Abdominal hyperalgesia in secretory phospholipase A2-induced rat pancreatitis: distinct roles of NK1 receptors

Acid suppression by omeprazole does not affect orally administered metronidazole bioavailability and metabolism in healthy male volunteers

Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test

Acute pulmonary inflammation induced by exposure of the airways to staphylococcal enterotoxin type B in rats

An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption.

Anti-inflammatory activity of crude extract and fractions of Nectandra falcifolia leaves

Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease

Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models

Bioavailability of four pharmaceutical formulations of metronidazole tested on normal healthy volunteers

Bioequivalence study of two enalapril maleate tablet formulations in healthy male volunteers Pharmacokinetic versus pharmacodynamic approach

Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.

COX-inhibiting nitric oxide donors (CINODs): potential benefits on cardiovascular and renal function

Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism.

Comparative bioavailability of two atenolol tablet formulations in healthy male volunteers after a single dose administration

Conversion of immunosuppressive monotherapy from cyclosporin a to tacrolimus reverses bone loss in rats

Daily cycling of nitric oxide synthase (NOS) in the hippocampus of pigeons (C. livia)

Early postnatal, but not late, exposure to chemical ambient pollutant 1,2-naphthoquinone increases susceptibility to pulmonary allergic inflammation at adulthood.

Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.

Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro

Effects of Selective Versus Non-Selective COX-2 Inhibition on Experimental Periodontitis

Effects of neonatal capsaicin treatment in the neutrophil production, and expression of preprotachykinin-I and tachykinin receptors in the rat bone marrow

Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 1: morphological and functional aspects

Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 2: biochemical aspects.

Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus.

Elucidating the role of oxidative stress in the therapeutic effect of rutin on experimental acute pancreatitis

Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products

Endothelin receptor antagonists: another potential alternative for cardiovascular diseases.

Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats

Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.

Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide

Gastric mucosal mast cells in atopic subjects

Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl est

H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreventative potential

Hydrogen Sulfide: An Endogenous Mediator of Resolution of Inflammation and Injury ⬇️

Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms

Hydrogen sulfide and dermatological diseases

Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice.

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1.

In vivo inhibition of nitric oxide synthesis does not depend on renin-angiotensin system activation.

Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation.

Inflammatory mechanisms underlying the rat pulmonary neutrophil influx induced by airway exposure to staphylococcal enterotoxin type A.

Influence of antiplatelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats

Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit

Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.

Intermittent therapy with 1,25 vitamin D and calcitonin prevents cyclosporin-induced alveolar bone loss in rats.

Intracellular mechanisms of hydroquinone toxicity on endotoxin-activated neutrophils.

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Laser photobiomodulation of pro-inflammatory mediators on Walker Tumor 256 induced rats.

Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats.

Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity

Lymphatic-borne IL-1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal ischema/reperfusion in rats

Mechanisms involved in the enhancement of allergic airways neutrophil influx by permanent C-fiber degeneration in rats

Mesenchymal Stromal Cell-Derived Microvesicles Regulate an Internal Pro-Inflammatory Program in Activated Macrophages

MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages.

Myeloperoxidase as Inflammatory Marker of Periodontal Disease: Experimental Study in Rats

Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?

Nitric oxide modulates lipopolysaccharide-induced endothelial platelet endothelial cell adhesion molecule expression via interleukin-10.

Nitric oxide synthase inhibitor influences prostaglandin and interleukin-1 production in experimental arthritic joints

Oral administration of antioxidants improves skin wound healing in diabetic mice

PAR(2) and temporomandibular joint inflammation in the rat.

Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.

Peripheral blood mononuclear phagocytes from patients with chronic periodontitis are primed for osteoclast formation.

Peripheral neurokinin-1 receptors contribute to kaolin-induced acute monoarthritis in rats

Plasma hydroxy metronidazole/metronidazole ratio in anti-HCV carriers with and without apparent liver disease

Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury

Platelet-rich plasma stimulates cytokine expression and alkaline phosphatase activity in osteoblast-derived osteosarcoma cells

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice.

Quantification of methyldopa in human plasma by high-performance liquid chromatography-electrospray tandem mass spectrometry application to a bioequivalence study.

Quantification of nimesulide in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Application to bioequivalence studies.

Reduction of inflammation in rats by diazepam: tolerance development.

Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus

Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions

Role of transient receptor potential vanilloid 4 in rat joint inflammation

Selective cyclo-oxygenase-2 inhibitors: cardiovascular and gastrointestinal toxicity