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List of works by Rob C Hoeben

A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer ⬇️

scientific article published on October 12, 2011

A cathepsin-cleavage site between the adenovirus capsid protein IX and a tumor-targeting ligand improves targeted transduction.

scientific article

A dual role of the N-terminal FQQI motif in GLUT4 trafficking

scientific article published on September 2009

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

scientific article

A lentiviral vector-based adenovirus fiber-pseudotyping approach for expedited functional assessment of candidate retargeted fibers

scientific article published on 01 November 2009

A polymorphism in the IL-10 promoter affects autoantibody production and subsequent joint destruction in rheumatoid arthritis.

scientific article

A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator

scientific article

A strategy for genetic modification of the spike-encoding segment of human reovirus T3D for reovirus targeting.

scientific article

A system for efficient generation of adenovirus protein IX-producing helper cell lines

scientific article published on February 2006

ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses

scientific article published on 30 January 2008

Activation or frustration of anti-tumor responses by T-cell-based immune modulation ⬇️

scientific article published on October 1, 1997

Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143

scientific article

Adenoviral transduction of dendritic cells

scientific article published on 01 January 2005

Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.

scientific article

Adenovirus 5 vector genetically re-targeted by an Affibody molecule with specificity for tumor antigen HER2/neu.

scientific article published on 2 February 2007

Adenovirus DNA replication

Adenovirus Receptor Expression in Cancer and Its Multifaceted Role in Oncolytic Adenovirus Therapy

scientific article published on 17 September 2020

Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX.

scientific article

Adenovirus-derived vectors for prostate cancer gene therapy

scientific article published on July 2010

Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.

scientific article

Alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice.

scientific article

Animal models in virus research: their utility and limitations

scientific article published on 14 September 2012

Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy ⬇️

scientific article published on 12 September 2018

Arming oncolytic reovirus with GM-CSF gene to enhance immunity

article

Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis

article

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.

scientific article published on 27 February 2017

Baculovirus-assisted Reovirus Infection in Monolayer and Spheroid Cultures of Glioma cells.

scientific article published on 15 December 2017

Bioluminescent reporter assay for monitoring ER stress in human beta cells

scientific article published in Scientific Reports

Biosafety of non-human therapeutic viruses in clinical gene therapy

scientific article published on December 2013

Cell replacement therapies: is it time to reprogram?

scientific article

Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells

scientific article published on 26 September 2006

Changing faces in virology: the dutch shift from oncogenic to oncolytic viruses

scientific article

Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.

scientific article published on January 1996

Characterization of adenovirus type 5 insertion and deletion mutants encoding altered DNA binding proteins

scientific article published on 01 October 1989

Characterization of an immuno 'stealth' derivative of the herpes simplex virus thymidine-kinase gene.

scientific article

Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle ⬇️

scientific article published on June 1, 1991

Clinical adenoviral gene therapy for prostate cancer

scientific article published on July 2010

Construction and biological activity of a full-length molecular clone of human Torque teno virus (TTV) genotype 6.

scientific article published on 22 August 2007

Conversion of mature human β-cells into glucagon-producing α-cells.

scientific article published on 8 April 2013

Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.

scientific article published on 27 May 2011

Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1.

scientific article published on November 2003

Cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live-virus vaccines

scientific article

DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.

scientific article

Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve

scientific article published on 3 April 2014

Development of an inducible suicide gene system based on human caspase 8.

scientific article published on July 2005

Differential expression of LFA-3, Fas and MHC Class I on Ad5- and Ad12-transformed human cells and their susceptibility to lymphokine-activated killer (LAK) cells

scientific article published on August 2005

Directed adenovirus evolution using engineered mutator viral polymerases

scientific article published on 7 December 2010

Efficient incorporation of a functional hyper-stable single-chain antibody fragment protein-IX fusion in the adenovirus capsid.

scientific article published on February 2007

Emergence of viral diseases: mathematical modeling as a tool for infection control, policy and decision making

scientific article published on August 2010

Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors.

scientific article published on 4 December 2010

Evaluating reporter genes of different luciferases for optimized in vivo bioluminescence imaging of transplanted neural stem cells in the brain

scientific article published in November 2013

Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants

scientific article

Exploring Reovirus Plasticity for Improving Its Use as Oncolytic Virus

scientific article

Expression of functional factor VIII in primary human skin fibroblasts after retrovirus-mediated gene transfer.

scientific article published on May 1990

Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region.

scientific article published in May 1995

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.

scientific article published on 13 January 2015

Factors impeding efficient expression of factor VIII complementary DNA minigenes.

scholarly article

Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene

scientific article

Gene therapy and cement injection for restabilization of loosened hip prostheses

scientific article published in January 2008

Gene therapy for the treatment of hip prosthesis loosening: adverse events in a phase 1 clinical study

scientific article

Gene therapy in The Netherlands: highlights from the Low Countries

scientific article published on October 2007

Gene therapy with apoptin induces regression of xenografted human hepatomas

scientific article

Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo

scientific article published on 21 May 2013

Herpesvirus microRNAs for use in gene therapy immune-evasion strategies

scientific article published on 9 May 2017

Heterogeneous reovirus susceptibility in human glioblastoma stem-like cell cultures.

scientific article published on 2 August 2013

Highly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cells

scientific article published on 01 November 2019

Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells.

scientific article published in April 2001

How not to be seen: immune-evasion strategies in gene therapy.

scientific article

Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure

scientific article published on 29 September 2017

Human adenovirus type 35 vector for gene therapy of brain cancer: improved transduction and bypass of pre-existing anti-vector immunity in cancer patients.

scientific article published on 3 November 2006

Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures

scientific article published on 01 July 1987

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis.

scientific article

Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion.

scientific article published on April 2004

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

scientific article published on 5 January 2018

In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus

scientific article published on 7 July 2006

Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position ⬇️

scientific article published on February 1, 1991

Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elements

scientific article published in April 2006

Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer

article

Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53.

scientific article published in April 2002

Insertion vectors for gene therapy.

scientific article published in February 2000

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components

scientific article published on 03 January 2020

Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization

scientific article published on 9 March 2011

Intronic SMCHD1 variants in FSHD: testing the potential for CRISPR-Cas9 genome editing

scientific article published on 01 November 2019

Invasion of synoviocytes is inhibited by gene transfer of TNF-BP or IL10 in an in vitro invasion model

scientific article published on 26 January 2001

Isolated human islets contain a distinct population of mesenchymal stem cells

scientific article published in May 2010

Isolated-organ perfusion for local gene delivery: efficient adenovirus-mediated gene transfer into the liver.

scientific article

Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.

scientific article

KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand

scientific article published on 01 May 2006

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes

scientific article published on February 2004

Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma

scientific article

Mammalian orthoreovirus T3D infects U-118 MG cell spheroids independent of junction adhesion molecule-A.

scientific article published on 17 April 2014

Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes

scientific article published on 15 April 2004

Modification of mammalian reoviruses for use as oncolytic agents

scientific article

Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene

scientific article published on February 2004

NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform

scientific article published on 15 August 2020

Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots

scientific article

New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses.

scientific article published on September 1998

New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation

scientific article published on 18 September 2013

Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?

scientific article published on 08 July 2020

Non-human viruses developed as therapeutic agent for use in humans

scientific article published on 11 May 2011

Off-label prescription of genetically modified organism medicines in europe: emerging conflicts of interest?

scientific article published on October 2014

Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery. ⬇️

scientific article published on 21 September 2017

Optimization of short-term transgene expression by sodium butyrate and ubiquitous chromatin opening elements (UCOEs).

scientific article published in August 2007

Optimizing reporter constructs for in vivo bioluminescence imaging of interferon-γ stimulated mesenchymal stromal cells

scientific article published on 15 April 2014

Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.

scientific article published on 12 November 2007

P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells

scientific article published on 6 November 2003

Photodynamic inactivation of retroviruses by phthalocyanines: the effects of sulphonation, metal ligand and fluoride

scientific article published on April 30, 1992

Polycistronic lentivirus induced pluripotent stem cells from skin biopsies after long term storage, blood outgrowth endothelial cells and cells from milk teeth

scientific article published in February 2013

Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer

scientific article published in Scientific Reports

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

scientific article published on 01 October 2020

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.

scientific article published on 24 June 2015

Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion

scientific article published on December 1997

Reappraisal of biosafety risks posed by PERVs in xenotransplantation

scientific article published on January 2008

Relaxed template specificity in fowl adenovirus 1 DNA replication initiation

scientific article published in March 2006

Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice

scientific article published on August 2008

Replicating reoviruses with a transgene replacing the codons for the head domain of the viral spike

scientific article

Safety of recombinant adenoviruses produced on adenovirus-transformed human cells.

scientific article

Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D.

scientific article published on December 2005

Serpina1 (alpha1-AT) is synthesized in the osteoblastic stem cell niche

scientific article

Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.

scientific article published in April 1998

Side effects of suicide gene therapy.

scientific article published in January 2004

Spacers increase the accessibility of peptide ligands linked to the carboxyl terminus of adenovirus minor capsid protein IX

scientific article published on April 2004

State and prospects of gene therapy for the hemophilias

scientific article published on 01 July 1995

Successful RAG1-SCID gene therapy depends on the level of RAG1 expression.

scientific article published on 26 June 2014

Targeting malignant gliomas with a glial fibrillary acidic protein (GFAP)-selective oncolytic adenovirus

scientific article

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity

scientific article

The 45-kDa form of Pdx-1 does not result from post-translational modifications

scientific article

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

scientific article

The adenovirus capsid: major progress in minor proteins

scientific article

The coiled-coil domain of the adenovirus type 5 protein IX is dispensable for capsid incorporation and thermostability

scientific article

The human clotting factor VIII cDNA contains an autonomously replicating sequence consensus- and matrix attachment region-like sequence that binds a nuclear factor, represses heterologous gene expression, and mediates the transcriptional effects of

scientific article published on 01 August 1996

The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.

scientific article published on 20 April 2007

The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state

scientific article published on 21 January 2005

The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells.

scientific article published in April 2003

The stability of envelope-pseudotyped lentiviral vectors

scientific article published on 24 September 2020

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies

scientific article published on 12 May 2014

Toward gene therapy for hemophilia A: long-term persistence of factor VIII-secreting fibroblasts after transplantation into immunodeficient mice.

scientific article published in April 1993

Toward gene therapy in haemophilia A: retrovirus-mediated transfer of a factor VIII gene into murine haematopoietic progenitor cells

scientific article published on 01 March 1992

Towards gene therapy for colorectal liver metastases.

scientific article

Towards gene therapy in prosthesis loosening: efficient killing of interface cells by gene-directed enzyme prodrug therapy with nitroreductase and the prodrug CB1954.

scientific article published in November 2005

Towards integrating vectors for gene therapy: expression of functional bacteriophage MuA and MuB proteins in mammalian cells.

scientific article published on December 2000

Truncating the i-leader open reading frame enhances release of human adenovirus type 5 in glioma cells

scientific article published on 11 April 2011

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

scientific article

[Gene therapy for hemophilia: feasible in principle but not yet clinically applicable]

scientific article published on 01 April 1998

[Stem cells: therapeutic applications and experimental techniques]

scientific article published on 01 January 2011

β-Cell Generation: Can Rodent Studies Be Translated to Humans?

scientific article

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