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List of works by Anthony S. Don

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids

scientific article published on 08 June 2020

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma

scientific article published on 21 February 2017

A fluorescent assay for ceramide synthase activity.

scientific article published on June 2012

A lipid binding domain in sphingosine kinase 2

scientific article published on 23 January 2009

A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.

scientific article

A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

scientific article

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

scientific article published in Nature Communications

A three-step assay for ceramide synthase activity using a fluorescent substrate and HPLC.

scientific article

ABCA8 stimulates sphingomyelin production in oligodendrocytes

scientific article

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.

scientific article published on 18 June 2016

Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration

scientific article published on 01 January 2018

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy

scientific article

Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry.

scientific article published in January 2016

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

scientific article

Contextual fear conditioning is enhanced in mice lacking functional sphingosine kinase 2.

scientific article published on 15 June 2017

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

scientific article published on 10 March 2022

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

scientific article

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice.

scientific article published on 26 February 2018

Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia

scientific article

Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.

scientific article published on 7 July 2010

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

scientific article

Fluorescent Assays for Ceramide Synthase Activity

scientific article published on 01 January 2016

High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma

scientific article published on 13 August 2019

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy.

scientific article published on 28 September 2015

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

scientific article published on 4 April 2016

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.

scientific article published on 9 July 2013

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.

scientific article published on 23 January 2014

Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains.

scientific article published in August 2011

Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.

scientific article published in October 2005

Mitochondria as cancer drug targets.

scientific article published in August 2004

Noninvasive imaging of cell death using an Hsp90 ligand.

scientific article published on 15 February 2011

Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order.

scientific article

Re-configuration of sphingolipid metabolism by oncogenic transformation

scientific article

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.

scientific article published on 31 August 2016

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

scientific article published on 11 September 2020

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes

scientific article published on 19 November 2019

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease

scientific article published on 22 October 2019

Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors

scientific article published on 04 November 2015

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.

scientific article published on 20 January 2013

Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.

scientific article

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy

scientific article published on 7 November 2017

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