List of works - Hirokazu Hirai

5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb.

scientific article

A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.

scientific article

A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors.

scientific article

A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.

scientific article

A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein

scientific article

A simple method using 31P-NMR spectroscopy for the study of protein phosphorylation

scientific article published in April 2000

Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release

scientific article published on November 2013

Adenosine enhances neuronal damage during deprivation of oxygen and glucose in guinea pig superior collicular slices

scientific article published on 01 December 1994

Adenosine facilitates glutamate release in a protein kinase-dependent manner in superior colliculus slices

scientific article

Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.

scientific article published on June 2013

Association between diastolic blood pressure and lower hemoglobin A1C and frontal brain atrophy in elderly subjects with diabetes mellitus

scientific article published in June 2006

Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

scientific article published on 07 July 2020

Basic Research on Cerebellar Gene Therapy Using Lentiviral Vectors ⬇️

scientific article published on June 1, 2012

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

scientific article published in July 2013

CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.

scientific article published on 23 September 2013

CD38 is critical for social behaviour by regulating oxytocin secretion

scientific article published on 7 February 2007

CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously

scientific article

Ca2+ permeability of the channel pore is not essential for the delta2 glutamate receptor to regulate synaptic plasticity and motor coordination

scientific article

Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.

scientific article published in July 2001

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

scientific article

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

scientific article

Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells

scientific article published on 11 December 2008

Clustering of delta glutamate receptors is regulated by the actin cytoskeleton in the dendritic spines of cultured rat Purkinje cells

scientific article published in February 2000

Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.

scientific article published on 4 April 2014

Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments

scientific article published on 14 June 2019

Displays of paternal mouse pup retrieval following communicative interaction with maternal mates ⬇️

scientific article published on January 1, 2013

Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.

scientific article published on 9 May 2011

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

scientific article published on 24 January 2020

Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.

scientific article

Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.

scientific article published on 14 January 2012

Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System

scientific article published on 05 October 2018

Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells

scientific article published in 2022

Excitatory and inhibitory effects of toluene on neural activity in guinea pig hippocampal slices

scientific article published in August 1993

Exogenously applied gangliosides (GM1, GD1a and Gmix) fail to facilitate the induction of long-term potentiation (LTP) in the slices of hippocampus and superior colliculus of the guinea pig.

scientific article published in April 1994

Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia

scientific article published on 12 July 2006

FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype.

scientific article

Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells.

scientific article published on 5 July 2016

Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.

scientific article

GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter

scientific article published on 15 February 2021

Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.

scientific article published on 19 December 2013

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein

scientific article published on 12 September 2014

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

scientific article

Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice ⬇️

scientific article published on January 14, 2013

Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia

scientific article published on 13 June 2016

Inhibition gates supralinear Ca signaling in Purkinje cell dendrites during practiced movements

scientific article published on 17 August 2018

Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production.

scientific article published in October 2006

Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells

scientific article (publication date: September 1999)

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

scientific article

Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain.

scientific article published on 23 November 2017

Ipsilateral corticotectal pathway inhibits the formation of long-term potentiation (LTP) in the rat superior colliculus through GABAergic mechanism

scientific article published on 01 November 1993

Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

scientific article published on 11 November 2013

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

scientific article

Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice

scientific article published on 25 February 2015

Long-term potentiation of neurotransmission in the inferior colliculus of the rat

scientific article published on 01 August 1995

Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240

scientific article published on 02 September 2018

Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1.

scientific article

Mesenchymal stem cells as a potential therapeutic tool for spinocerebellar ataxia.

scientific article published on April 2015

Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice

scientific article published on 28 December 2015

Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates.

scientific article

Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity.

scientific article

Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice

scientific article published on 3 May 2016

Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.

scientific article published in October 2011

Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.

scientific article published on February 2014

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

scientific article published on 27 July 2015

New role of delta2-glutamate receptors in AMPA receptor trafficking and cerebellar function.

scientific article published in August 2003

Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons

scientific article published on 31 July 2014

One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice

scientific article published on 3 July 2014

Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.

scientific article published on August 2012

Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.

scientific article published on 30 June 2015

Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3 ⬇️

scientific article published on April 6, 2013

Potential usefulness of D2R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases

scientific article

Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.

scientific article published on 21 July 2016

Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums.

scientific article published on 13 November 2017

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

scientific article published on 21 October 2015

Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging

scientific article

Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells.

scientific article

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

scientific article published on 15 May 2014

Retrograde signaling for climbing fiber synapse elimination

scientific article

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

scientific article published on 20 January 2016

Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function

scientific article

Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice

scientific article

Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice

scientific article

The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death

scientific article published on 12 May 2010

The contribution of PKA to the excitatory mechanism of adenosine in guinea pig superior colliculus slices

scientific article published on 01 November 1994

The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

scientific article published on June 1996

The murine stem cell virus promoter drives correlated transgene expression in the leukocytes and cerebellar Purkinje cells of transgenic mice

scientific article

The release of glutamate and accumulation of intracellular calcium in the guinea pig hippocampal slices during glucose deprivation.

scientific article

The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling.

scientific article published on 30 August 2008

Toluene inhibits synaptic transmission without causing gross morphological disturbances

scientific article published on 01 November 1994

Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.

scientific article published on 16 February 2016

Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice

scientific article published on 19 December 2014

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.

scientific article published on May 2010

Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders

scientific article published on 8 March 2018

Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains

scientific article

Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo

scientific article published on 15 May 2017

List of works by Hirokazu Hirai

5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb.

A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.

A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors.

A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.

A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein

A simple method using 31P-NMR spectroscopy for the study of protein phosphorylation

Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release

Adenosine enhances neuronal damage during deprivation of oxygen and glucose in guinea pig superior collicular slices

Adenosine facilitates glutamate release in a protein kinase-dependent manner in superior colliculus slices

Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.

Association between diastolic blood pressure and lower hemoglobin A1C and frontal brain atrophy in elderly subjects with diabetes mellitus

Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Basic Research on Cerebellar Gene Therapy Using Lentiviral Vectors ⬇️

Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease

CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice.

CD38 is critical for social behaviour by regulating oxytocin secretion

CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously

Ca2+ permeability of the channel pore is not essential for the delta2 glutamate receptor to regulate synaptic plasticity and motor coordination

Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.

Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells

Clustering of delta glutamate receptors is regulated by the actin cytoskeleton in the dendritic spines of cultured rat Purkinje cells

Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.

Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments

Displays of paternal mouse pup retrieval following communicative interaction with maternal mates ⬇️

Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice.

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.

Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.

Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System

Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells

Excitatory and inhibitory effects of toluene on neural activity in guinea pig hippocampal slices

Exogenously applied gangliosides (GM1, GD1a and Gmix) fail to facilitate the induction of long-term potentiation (LTP) in the slices of hippocampus and superior colliculus of the guinea pig.

Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia

FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype.

Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells.

Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.

GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter

Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice ⬇️

Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia

Inhibition gates supralinear Ca signaling in Purkinje cell dendrites during practiced movements

Inositol 1,4,5-trisphosphate receptor type 1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production.

Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain.

Ipsilateral corticotectal pathway inhibits the formation of long-term potentiation (LTP) in the rat superior colliculus through GABAergic mechanism

Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice

Long-term potentiation of neurotransmission in the inferior colliculus of the rat

Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240

Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1.

Mesenchymal stem cells as a potential therapeutic tool for spinocerebellar ataxia.

Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice

Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates.

Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity.

Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice

Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.

Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

New role of delta2-glutamate receptors in AMPA receptor trafficking and cerebellar function.

Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons

One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice

Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.

Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.

Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3 ⬇️

Potential usefulness of D2R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases

Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.

Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums.

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging

Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells.

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

Retrograde signaling for climbing fiber synapse elimination

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles