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List of works by Mark J. Taylor

<i>Wolbachia</i> depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment

scientific article published on 04 April 2022

A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry

scientific article published on 28 October 2014

A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis

scientific article

A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection.

scientific article published on 14 March 2006

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Absence of Wolbachia endobacteria in the human parasitic nematode Dracunculus medinensis and two related Dracunculus species infecting wildlife

scientific article published on 31 March 2014

Absence of Wolbachia endobacteria in the non-filariid nematodes Angiostrongylus cantonensis and A. costaricensis

scientific article published on 18 September 2008

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.

scientific article published on 23 October 2017

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages

scientific article published on 10 February 2015

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

scientific article

Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes.

scientific article

Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability ⬇️

scientific article published on May 1, 2003

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

scientific article

Autophagy regulates Wolbachia populations across diverse symbiotic associations

scientific article

Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes ⬇️

scientific article published on April 18, 2012

Brugia malayi Wolbachia hsp60 IgG antibody and isotype reactivity in different clinical groups infected or exposed to human bancroftian lymphatic filariasis.

scientific article

Characterization of a secreted antigen of Onchocerca volvulus with host‐protective potential ⬇️

scientific article published on January 1, 1996

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

scientific article

Culture and phenotypic characterization of a Wolbachia pipientis isolate

scientific article

Current practices in the management of lymphatic filariasis.

scientific article published on June 2009

Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.

scientific article

Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway

scientific article

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

scientific article published on 01 May 2019

Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?

scientific article

Down-regulated lymphoproliferation coincides with parasite maturation and with the collapse of both gamma interferon and interleukin-4 responses in a bovine model of onchocerciasis

scientific article published on July 2001

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

scientific article

Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms

scientific article published on April 2003

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

scientific article

Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment

scientific article

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

scientific article

Endosymbiotic bacteria associated with nematodes, ticks and amoebae

scientific article

Evidence against Wolbachia symbiosis in Loa loa

scientific article

Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi

scientific article

Filarial infection influences mosquito behaviour and fecundity

scientific article published on 31 October 2016

Generation of Loa loa infective larvae by experimental infection of the vector, Chrysops silacea

scientific article published on 17 August 2020

Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro

scientific article

IL-4 dependent resistance to the tapeworm Mesocestoides corti (Cestoda) in mice

scientific article

IL-5-dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis ⬇️

scientific article published on June 1, 1998

Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library

scientific article published on 27 September 2017

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

scientific article (publication date: February 2014)

Increasing evidence of low lymphatic filariasis prevalence in high risk Loa loa areas in Central and West Africa: a literature review.

scientific article

Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis.

scientific article published on December 2003

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.

scientific article

Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes

scientific article

Live Brugia malayi Microfilariae Inhibit Transendothelial Migration of Neutrophils and Monocytes ⬇️

scientific article published on November 29, 2012

Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis ⬇️

scientific article published on March 20, 2012

Lymphatic filariasis and onchocerciasis ⬇️

scientific article published on August 23, 2010

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

scientific article

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial

scientific article

Mass drug treatment for lymphatic filariasis and onchocerciasis ⬇️

scientific article published on November 1, 2003

Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro.

scientific article

Onchocerciasis control: vision for the future from a Ghanian perspective

scientific article published on 21 January 2009

Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment ⬇️

scientific article published on July 1, 2011

Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience

scientific article

Population dynamics of Wolbachia bacterial endosymbionts in Brugia malayi.

scientific article published on May 2004

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

scientific article published on 01 March 2019

Protective immunity induced by vaccination with Onchocerca volvulus tropomyosin in rodents ⬇️

scientific article published on May 1, 1996

Quantifying the socio-economic impact of leg lymphoedema on patient caregivers in a lymphatic filariasis and podoconiosis co-endemic district of Ethiopia

scientific article published on 03 March 2020

Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline.

scientific article

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

scientific article

Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes

scientific article

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

scientific article

Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood.

scientific article published on December 2001

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.

scientific article

The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

scientific article

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

scientific article published on 23 December 2014

Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian filariasis

scientific article

Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis.

scientific article

Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models.

scientific article

Whole-genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence

scientific article published on 20 August 2013

Wolbachia bacteria of filarial nematodes.

scientific article

Wolbachia bacterial endosymbionts of filarial nematodes

scientific article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article published in 2008

Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.

scientific article published on 19 May 2009

Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus

scientific article

Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88

scientific article

Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness).

scientific article published on October 2004

Wolbachiafilarial interactions ⬇️

scientific article published on December 24, 2012

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