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List of works by Diego Megías

A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka.

scientific article published on 3 January 2011

A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

scientific article published on 14 December 2011

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

scientific article published on 31 August 2015

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

scientific article published on 21 June 2016

Application of standard cell cultures and 3D in vitro tissue models as an effective tool in drug design and development.

scientific article

Assessing kinetics and recruitment of DNA repair factors using high content screens

scientific article published on 01 December 2021

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 01 September 2018

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer.

scientific article published on 02 February 2017

CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions

scientific article

Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge.

scientific article published on 13 July 2016

Combinatorial effects of splice variants modulate function of Aiolos

scientific article

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.

scientific article published on 02 February 2017

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias

scientific article

Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

scientific article published in September 2004

EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.

scientific article

Fra-2-expressing macrophages promote lung fibrosis in mice

scientific article published on 28 May 2019

Gasdermin-B promotes invasion and metastasis in breast cancer cells

scientific article

Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division

scientific article published on 20 January 2022

Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.

scientific article published on 13 October 2016

HCS Methodology for Helping in Lab Scale Image-Based Assays

scientific article published on 01 January 2019

High-Throughput Image-Based Screening to Identify Chemical Compounds Capable of Activating FOXO

scientific article published on 01 January 2019

Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor

scientific article

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

scientific article

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

scientific article published in November 2017

Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways

scientific article published on 24 June 2013

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

scientific article (publication date: November 2014)

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

scientific article published in May 2017

Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135

scientific article published on 8 May 2020

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

scientific article

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

scientific article

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

scientific article published on 02 September 2019

Lysosomal trapping of palbociclib and its functional implications

scientific article published on 28 January 2019

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells

scientific article

MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.

scientific article

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

scientific article published on 25 November 2021

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

scientific article published on 26 August 2015

Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

scientific article published on 22 December 2015

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

scientific article published on 24 October 2014

Novel lambda FRET spectral confocal microscopy imaging method

scientific article published in January 2009

PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection

scientific article published on 22 November 2019

Podoplanin associates with CD44 to promote directional cell migration

scientific article published on 20 October 2010

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

scientific article published on 17 October 2006

Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.

scientific article

Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.

scientific article

Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1.

scientific article

RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway

scientific article

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

scientific journal article

Reply: 'Comments on Stromal disrupting effects of nab-paclitaxel in pancreatic cancer'.

scientific article published on 18 March 2014

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

scientific article

Role of C/EBPβ transcription factor in adult hippocampal neurogenesis

scientific article

Role of bulge epidermal stem cells and TSLP signaling in psoriasis

scientific article published on 26 September 2019

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

scientific article

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 11 June 2018

Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

scientific article published on 08 August 2019

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

scientific article published on 20 September 2019

Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression

scientific article

Specific targeting of human inflamed endothelium and in situ vascular tissue transfection by the use of ultrasound contrast agents

scientific article published in August 2009

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

scientific article published on 21 December 2017

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

scientific article published on 18 April 2018

Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells

scientific article

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.

scientific article

The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.

scientific article published on 3 March 2011

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK ⬇️

scientific article published on August 14, 2012

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

scientific article published on 13 May 2015

Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.

scientific article published on 14 February 2018

Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

scientific article published on 27 September 2019

Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis ⬇️

scientific article published on August 22, 2012

Vitrification versus slow freezing of oocytes: effects on morphologic appearance, meiotic spindle configuration, and DNA damage

scientific article published on 9 September 2010

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

scientific article

c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis

scientific article published on 3 February 2017

iMSRC: converting a standard automated microscope into an intelligent screening platform

scientific article published on 27 May 2015

p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals

scientific article

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors

scientific article published on 20 December 2018

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