List of works by David I Finkelstein

A novel approach to rapidly prevent age-related cognitive decline

scientific article

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

scientific article published on 22 December 2015

Acute Neurotoxicity Models of Prion Disease.

scientific article published on 2 February 2018

Age modulates the injury-induced metallomic profile in the brain.

scientific article

Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function

scientific article (publication date: 2013)

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization

scientific article published on 10 December 2020

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

scientific article

Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.

scientific article

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

scientific article published on 19 February 2013

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology

scientific article published on 01 January 2020

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease

scientific article published on 10 November 2019

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

scientific article

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

scientific article published on 18 March 2015

Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy

scientific article published on 9 June 2015

Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

scientific article published on 07 September 2016

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

scientific article published on 27 October 2011

Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc

scientific article published on 10 April 2019

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

scientific article

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

scientific article

Enhancing neurite outgrowth from primary neurones and neural stem cells using thermoresponsive hydrogel scaffolds for the repair of spinal cord injury.

scientific article published in April 2009

Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease

scientific article

Exercise and physical activity for people with Progressive Supranuclear Palsy: a systematic review

scientific article published on 27 September 2019

Ferroptosis and cell death mechanisms in Parkinson's disease.

scientific article published on 9 January 2017

Fibrillar α-synuclein toxicity depends on functional lysosomes

scientific article published on 07 October 2020

GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

scientific article

Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?

scientific article published on 25 June 2014

Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain

scientific article

H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load

scientific article

High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer

scientific article

Implantation of functionalized thermally gelling xyloglucan hydrogel within the brain: associated neurite infiltration and inflammatory response

scientific article published in September 2010

In vivo prion models and the disconnection between transmissibility and neurotoxicity

scientific article published on 24 April 2017

Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels

scientific article published on 24 January 2014

Interactions of metals and Apolipoprotein E in Alzheimer's disease

scientific article published in 2014

Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes

scientific article published on 10 February 2016

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

scientific article

Is early-life iron exposure critical in neurodegeneration?

scientific article published on 23 June 2015

Large-scale sequence analysis of avian influenza isolates.

scientific article

Lithium suppression of tau induces brain iron accumulation and neurodegeneration. ⬇️

scientific article published on 12 July 2016

Metal chaperones prevent zinc-mediated cognitive decline

scientific article published on 27 December 2014

Metal chaperones: a novel therapeutic strategy for brain injury?

scientific article published on 03 December 2018

Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies

scientific article

Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.

scientific article

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling β-Peptide Hydrogel

scientific article published on 08 November 2019

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

scientific article published on 17 January 2020

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

scientific article published on 03 July 2018

Motor and cognitive deficits in aged tau knockout mice in two background strains.

scientific article

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

scientific article published on 14 May 2016

Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

scientific article

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.

scientific article published on 16 August 2016

Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma

scientific article

Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

scientific article published on 14 March 2017

Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species

scientific article published on 08 August 2018

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

scientific article

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism

scientific article published on 23 October 2020

Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

scientific article published on 20 December 2019

Rescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter

scientific article

Restoration of intestinal function in an MPTP model of Parkinson's Disease

scientific article published on 29 July 2016

Role of metal ions in the cognitive decline of Down syndrome.

scientific article

Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias

scientific article published on 4 February 2015

Targeting metals rescues the phenotype in an animal model of tauopathy

scientific article published on 01 September 2018

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

scientific article published on 29 January 2012

Tau protein: relevance to Parkinson's disease

scientific article

The effect of dopamine on MPTP-induced rotarod disability.

scientific article published on 2 April 2013

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

scientific article

The role of lipids in α-synuclein misfolding and neurotoxicity.

scientific article published on 7 May 2019

Therapeutic applications of chelating drugs in iron metabolic disorders of the brain and retina

scientific article published on 09 July 2020

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain

scientific article

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra

scientific article published on 02 September 2016

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.

scientific article published on 30 August 2017

Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury

scientific article published on 01 June 2018

Trehalose improves traumatic brain injury-induced cognitive impairment

scientific article published on 24 August 2017

Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease.

scientific article published on 12 July 2016

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

scientific article

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

scientific article published on 28 June 2019

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

scientific article published on 27 July 2015

Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way.

scientific article

l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease

scientific article published on 28 March 2019

α-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon

scientific article published on 06 November 2019

α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.

scientific article published on 13 May 2010

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